CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM6725
Family Name Coagulation factor X and Prothrombin inhibitor (2S)-2-(benzylsulfonylamino)-N-[2-[[(2R)-5-(diaminomethylideneamino)-1-oxo-1-(1,3-thiazol-2-yl)pentan-2-yl]amino]-2-oxoethyl]-3-(1H-indol-3-yl)propanamide family
No. of Seeds 4 No. of Other Members 4
Family Centroid CFAMM00374553 Functional Category Bioactive
Superfamily Prothrombin and Coagulation factor X Binder Superfamily
Class Class 2076

Cousin Family NamesSeedsMembers
Growth hormone receptor Ligand EP-51216 Family 34 390
mRNA of Glucagon receptor Ligand Isis 325568 Family 1 3
Lethal factor Inhibitor GM6001 Family 50 435
Somatostatin receptor type 2 Ligand L-054852 Family 13 88
Prothrombin Inhibitor RWJ-50353 Family 11 95
Coagulation factor X Inhibitor Phso2-gly-(me-gly)-arg-(2-thiaz... 32 62
Poly [ADP-ribose] polymerase 1 Inhibitor N-(4-phenylthiazol-2-... 6 150
Endothelin B receptor Ligand IRL-2500 Family 34 87
Vasopressin V1a receptor and Vasopressin V1b receptor Ligand D... 10 19
Bombesin receptor subtype-3 and Gastrin-releasing peptide rece... 42 7
Prothrombin inhibitor (6S,8aS)-N-[5-(diaminomethylideneamino)-... 12 10
Deoxycytidine kinase inhibitor N-[(1S,3S)-3-(4-amino-5-fluoro-... 2 5
Dipeptidyl peptidase 1 inhibitor (2S)-2-amino-N-[(1S)-1-cyano-... 2 14
Prothrombin inhibitor N-[(2S)-3-[(3S)-1-carbamimidoylpiperidin... 4 10
Growth hormone secretagogue receptor type 1 ligand 2-amino-N-[... 1 0
Coagulation factor XI and Prothrombin inhibitor alpha-ketothia... 5 2
Neuropeptide Y receptor type 5 ligand 2-phenyl-1-[(1R,5S)-6-[[... 9 11
Prothrombin inhibitor (2S)-N-[(4-carbamimidoyl-1,3-thiazol-2-y... 3 2
Survival motor neuron protein and Menin inhibitor CHEMBL151109... 1 11
Coagulation factor X and Prothrombin inhibitor AGN-PC-0754DR f... 2 2
Coagulation factor X and Prothrombin inhibitor 2-[(3S)-3-benzy... 7 0
Coagulation factor X and Prothrombin inhibitor N-[5-(diaminome... 2 0
Trypsin-1 and Prothrombin inhibitor (6S,8aS)-N-[(2S)-5-(diamin... 1 1
Prothrombin inhibitor (3R,6S,8aS)-N-[5-(diaminomethylideneamin... 2 3
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 5 1
Orexin receptor type 1 and Orexin receptor type 2 ligand N-[[(... 9 5
Suppressor of tumorigenicity 14 protein and Serine protease he... 6 0
Cathepsin K and Cathepsin L1 inhibitor (2R)-N-(cyanomethyl)-4-... 2 1
D(3) dopamine receptor and D(2) dopamine receptor ligand [4-[2... 6 5
Glucocorticoid receptor ligand 3-(1H-indol-5-yl)-2,2-dimethyl-... 2 7
Platelet-activating factor receptor ligand (1-ethylindol-3-yl)... 17 13
Prothrombin and Cationic trypsin inhibitor 2-ketobenzothiazole... 1 0
Prothrombin and Trypsin-1 inhibitor 2-[(2S)-4-benzyl-2-(naphth... 1 0
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor CHEMBL3... 1 9
Methionine aminopeptidase 1 inhibitor N-[5-[2-oxo-2-[4-(2-pyri... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00374551 CHEMBL320781 Bioactive (6S,8aS)-2-[(2S)-2-amino-3-(1H-indol-3-yl)propanoyl]-N-[5-(diaminomethylideneamino)-1-oxo-1-(1,3-thiazol-2-yl)pentan-2-yl]-4-oxo-1,3,6,7,8,8a-hexahydropyrrolo[1,2-a]pyrazine-6-carboxamide
CFAMM00374554 CHEMBL401963 Bioactive (2R)-2-(benzylsulfonylamino)-N-[2-[[(2S)-5-(diaminomethylideneamino)-1-oxo-1-(1,3-thiazol-2-yl)pentan-2-yl]amino]-2-oxoethyl]-3-(1H-indol-3-yl)propanamide
CFAMM00374553 CHEMBL159734 Bioactive (2S)-2-(benzylsulfonylamino)-N-[2-[[(2R)-5-(diaminomethylideneamino)-1-oxo-1-(1,3-thiazol-2-yl)pentan-2-yl]amino]-2-oxoethyl]-3-(1H-indol-3-yl)propanamide
CFAMM00374552 CHEMBL438351 Bioactive (6S,8aS)-2-[(2R)-2-amino-3-(1H-indol-2-yl)propanoyl]-N-[(2S)-5-(diaminomethylideneamino)-1-oxo-1-(1,3-thiazol-2-yl)pentan-2-yl]-4-oxo-1,3,6,7,8,8a-hexahydropyrrolo[1,2-a]pyrazine-6-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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