CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM6779
Family Name D(2) dopamine receptor and D(3) dopamine receptor ligand 1,1-dioxo-2-[4-(4-phenylpiperazin-1-yl)butyl]-1,2-benzothiazol-3-one family
No. of Seeds 2 No. of Other Members 7
Family Centroid CFAMM00231006 Functional Category Bioactive with Natural Product
Superfamily Menin and Caspase-3 Binder Superfamily
Class Class 545

Cousin Family NamesSeedsMembers
Mu-type opioid receptor Ligand Fentanyl Family 9 647
Alpha adrenergic receptor Ligand Droperidol Family 20 244
Sodium channel protein type 5 subunit alpha Ligand Procainamid... 7 291
Serum albumin Inhibitor Ebselen Family 3 62
Motilin receptor Ligand GSK962040 Family 30 457
K-604 family 4 71
Dual specificity mitogen-activated protein kinase kinase Inhib... 7 69
Potassium voltage-gated channel subfamily A member 5 Ligand S-... 34 206
C-C chemokine receptor type 5 Ligand Tak-220 Family 8 56
Caspase-3 Inhibitor 5-(pyrrolidin-1-ylsulfonyl)indoline-2,3-di... 5 35
Vasopressin V1a receptor and Vasopressin V2 receptor Ligand OP... 12 94
72 kDa type IV collagenase Inhibitor SC-74020 Family 1 21
Carbonic anhydrase 2 Inhibitor N-benzyl-4-sulfamoyl-benzamide ... 12 44
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor N-(4-s... 12 92
Potassium voltage-gated channel subfamily A member 5 Ligand N-... 8 32
3-oxo-5-alpha-steroid 4-dehydrogenase 1 Inhibitor 1-methyl-5-(... 6 17
Integrin beta-3 Inhibitor L-750034 Family 7 38
C-C chemokine receptor type 8 Ligand N-(4-phenylsulfamoyl-naph... 4 62
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 3 26
Oxysterols receptor LXR-alpha Ligand 2-(2-phenethylphenyl)isoi... 4 7
Transient receptor potential cation channel subfamily V member... 1 5
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor Saccha... 2 13
Cannabinoid receptor 2 Ligand N1-(4-bromophenyl)-n2,n2-dipenty... 4 21
Phospholipase D1 Inhibitor Halopemide Family 17 111
5-hydroxytryptamine receptor 7 Ligand UCM-5600 Family 15 46
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor 4-(2-p... 6 19
Reverse transcriptase Inhibitor 10-propyl-10h-dibenzo[b,f][1,4... 1 14
D(2) dopamine receptor Ligand PD-168077 Family 6 5
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 53 289
D(4) dopamine receptor ligand AGN-PC-074VC9 family 2 3
5-hydroxytryptamine receptor 6 ligand 1-(5-chloronaphthalen-1-... 1 5
Acetylcholinesterase inhibitor AGN-PC-07ZFTY family 1 0
Neutrophil elastase inhibitor SureCN7448165 family 2 4
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 5
Acetylcholinesterase inhibitor CHEMBL1651130 family 2 3
Acetylcholinesterase inhibitor 2-[2-(1-benzylpiperidin-4-yl)et... 2 9
Cellular tumor antigen p53 inhibitor CHEMBL1554992 family 1 0
Thyroid hormone receptor beta ligand CHEMBL1593113 family 1 4
Cannabinoid receptor 2 ligand 4-methyl-3-piperidin-1-ylsulfony... 2 0
5-hydroxytryptamine receptor 6 and 5-hydroxytryptamine recepto... 3 12
B1 bradykinin receptor ligand SureCN1712821 family 5 3
Protein-glutamine gamma-glutamyltransferase 2 and Coagulation ... 1 0
Inosine-5'-monophosphate dehydrogenase 2 inhibitor SureCN32339... 2 2
Bifunctional epoxide hydrolase 2 inhibitor 1-(2,4-dimethylphen... 4 8
Bifunctional epoxide hydrolase 2 inhibitor N-(2-chlorophenyl)-... 2 1
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltra... 5 10
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 4 6
Cannabinoid receptor 2 ligand AGN-PC-04VLWN family 9 4
Cannabinoid receptor 2 ligand N-cyclohexyl-4-propan-2-yl-3-pyr... 2 2
5-hydroxytryptamine receptor 1A and Alpha-2B adrenergic recept... 2 2
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 3 2
C-C chemokine receptor type 5 and Potassium voltage-gated chan... 4 0
Carbonic anhydrase 2 inhibitor N-[(4-nitrophenyl)methyl]-4-sul... 1 2
C-C chemokine receptor type 8 ligand 3-pyrrolidin-1-ylpropyl 4... 2 0
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 1 inhibi... 1 0
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor KB-74... 2 0
C-C chemokine receptor type 5 ligand AC1MHPA7 family 2 2
Calpain-1 catalytic subunit inhibitor 2-methyl-6-morpholin-4-y... 1 2
Protein-glutamine gamma-glutamyltransferase 2 and Coagulation ... 3 2
Histidinol dehydrogenase inhibitor 2-(1-benzyl-2-oxo-5-thiomor... 1 4
Chymase and Cathepsin G inhibitor SureCN4452567 family 2 2
Chymase and Chymotrypsinogen A inhibitor SureCN7836048 family 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00374887 CHEMBL519121 Bioactive N-[4-[(2S)-2-[(3S)-3-aminopyrrolidine-1-carbonyl]piperidin-1-yl]sulfonylphenyl]-2-fluorobenzamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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