CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

Family Name Cathepsin S inhibitor ethyl 2-[[3-[[(2S)-3-cyclohexyl-2-[(6-methylpyrazine-2-carbonyl)amino]propanoyl]amino]-2-oxo-4-phenylmethoxybutanoyl]amino]acetate family
No. of Seeds 2 No. of Other Members 3
Family Centroid CFAMM00314243 Functional Category Bioactive
Superfamily Beta-lactamase and Cathepsin S Binder Superfamily
Class Class 963

Cousin Family NamesSeedsMembers
Cannabinoid receptor 1 Ligand N-phenyl-5,6-dip-tolylpyrazine-2... 11 26
Sodium channel protein type 10 subunit alpha and Sodium channe... 3 22
Pol polyprotein inhibitor AC1LALGZ family 2 14
Substance-P receptor ligand [(3S,4R)-3-[(1R)-1-[3,5-bis(triflu... 1 0
Cannabinoid receptor 1 ligand N-(1-hydroxy-2,3-dihydro-1H-inde... 1 0


External ID

Functional Category

Molecule Name

CFAMM00314239 CHEMBL153248 Bioactive N-[(2S)-1-[[(1R)-1-cyano-2-phenylmethoxyethyl]amino]-3-cyclohexyl-1-oxopropan-2-yl]pyrazine-2-carboxamide
CFAMM00314243 CHEMBL1085980 Bioactive ethyl 2-[[3-[[(2S)-3-cyclohexyl-2-[(6-methylpyrazine-2-carbonyl)amino]propanoyl]amino]-2-oxo-4-phenylmethoxybutanoyl]amino]acetate

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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Computer-aided Drug Design
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