CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM6900
Family Name D(3) dopamine receptor and D(2) dopamine receptor ligand 3-[4-[2-[4-(3,4-dichlorophenyl)piperazin-1-yl]ethyl]cyclohexyl]-1,1-dimethylurea family
No. of Seeds 4 No. of Other Members 23
Family Centroid CFAMM00375589 Functional Category Bioactive
Superfamily D(2) dopamine receptor and D(3) dopamine receptor Binder Superfamily 19
Class Class 2396

Cousin Family NamesSeedsMembers
Mu-type opioid receptor Ligand Fentanyl Family 9 647
D(2) dopamine receptor ligand diphenylbutylpiperidine derivati... 10 157
Dopamine receptor Ligand Domperidone Family 2 21
D(2) dopamine receptor ligand diphenylbutylpiperidine derivati... 43 161
Motilin receptor Ligand GSK962040 Family 30 457
Serine/threonine-protein kinase mTOR Inhibitor CC-223 Family 12 135
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 19 186
Bifunctional epoxide hydrolase 2 Inhibitor 1-(3-chloro-phenyl)... 5 50
Bifunctional epoxide hydrolase 2 Inhibitor N-(3-chloro-phenyl)... 2 43
Androgen receptor Ligand YM-175735 Family 30 129
Carbonic anhydrase 2 and Carbonic anhydrase 4 Inhibitor 1-(3,4... 2 9
Cannabinoid receptor 1 Ligand 1-(bis(4-chlorophenyl)methyl)-3-... 4 44
Histamine H3 receptor Ligand VUF-10214 Family 3 7
Phospholipase D1 Inhibitor Halopemide Family 17 111
5-hydroxytryptamine receptor 3A Ligand 1-(biphenyl-4-yl)-3-(4-... 20 67
Bifunctional epoxide hydrolase 2 Inhibitor 1-phenyl-3-(1-propi... 22 183
Induced myeloid leukemia cell differentiation protein Mcl-1 an... 2 7
DNA topoisomerase Inhibitor 6-(3-iodo-phenylamino)-1h-pyrimidi... 2 5
D(2) dopamine receptor and D(3) dopamine receptor ligand AGN-P... 4 18
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-07ZBI0 family 2 16
Bifunctional epoxide hydrolase 2 and Cytochrome P450 2C8 inhib... 6 5
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 5 2
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 15 24
D(4) dopamine receptor and Alpha-1B adrenergic receptor ligand... 7 27
D(3) dopamine receptor and D(2) dopamine receptor ligand 1-(3-... 6 12
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 3 1
D(4) dopamine receptor and Alpha-1B adrenergic receptor ligand... 2 6
Melanin-concentrating hormone receptor 1 ligand 1-[(6S)-6-(3-c... 7 18
Melanin-concentrating hormone receptor 1 ligand 3-(3-chloro-4-... 8 24
D(3) dopamine receptor and Alpha-1B adrenergic receptor ligand... 11 8
Substance-P receptor ligand (2S,4S)-2-N-[3-(diethylamino)propy... 2 7
C-C chemokine receptor type 2 and C-C chemokine receptor type ... 2 8
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[(E... 24 11
Melanin-concentrating hormone receptor 1 ligand 1-[[4-[4-(3-cy... 14 23
Melanin-concentrating hormone receptor 1 ligand SureCN3845324 ... 7 4
C-C chemokine receptor type 1 ligand SureCN3159355 family 7 9
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 11 3
Kappa-type opioid receptor and Cytochrome P450 2D6 ligand Sure... 1 0
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[4-... 5 2
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[4-... 1 1
D(3) dopamine receptor and D(2) dopamine receptor ligand RGH-1... 8 0
Melanin-concentrating hormone receptor 1 ligand SureCN14265866... 11 2
Melanin-concentrating hormone receptor 1 and Potassium voltage... 2 2
Melanin-concentrating hormone receptor 1 ligand AGN-PC-00CYMY ... 1 0
Inosine-5'-monophosphate dehydrogenase inhibitor 1-(3,4-dichlo... 1 1
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor N-(2-... 1 0
Histamine H3 receptor and Histamine receptor H3 ligand 1-(3,5-... 4 0
C-C chemokine receptor type 1 ligand N-[(2R)-1-[4-(4-chlorophe... 2 3
Nociceptin receptor and Delta-type opioid receptor ligand spir... 25 9
Kappa-type opioid receptor ligand AGN-PC-077Q4Y family 5 9
Kappa-type opioid receptor and Urotensin-2 receptor ligand 2-(... 5 1
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[4-... 4 0
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 4 1
Melanin-concentrating hormone receptor 1 ligand SureCN13451707... 3 1
Neuropeptide Y receptor type 5 ligand 3-[1-(3,5-dichlorophenyl... 1 0
Neuropeptide Y receptor type 5 ligand SureCN6214451 family 3 1
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 3 0
Matrix metalloproteinase-9 and Neutrophil collagenase inhibito... 3 2
Potassium voltage-gated channel subfamily H member 2 and D(3) ... 3 0
D(3) dopamine receptor and D(2) dopamine receptor ligand 1-(3-... 2 1
Bloom syndrome protein and Prelamin-A/C inhibitor DCEBIO family 1 1
Acyl-CoA:cholesterol acyltransferase inhibitor 1-[2,6-di(propa... 7 2
5-hydroxytryptamine receptor 1A ligand AGN-PC-07C0GW family 1 0
Glycogen phosphorylase, liver form inhibitor TCMDC-135759 family 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00375565 CHEMBL2024520 Bioactive [4-[2-[4-(3,4-dichlorophenyl)piperazin-1-yl]ethyl]cyclohexyl]urea
CFAMM00375579 CHEMBL2036757 Bioactive 4-[[(3S)-1-cyclopropylpiperidin-3-yl]methyl]-N-(3,4-dichlorophenyl)piperazine-1-carboxamide
CFAMM00375578 CHEMBL2036755 Bioactive N-(3,4-dichlorophenyl)-4-[[(3R)-1-(2-phenylethyl)piperidin-3-yl]methyl]piperazine-1-carboxamide
CFAMM00375589 CHEMBL2024676 Bioactive 3-[4-[2-[4-(3,4-dichlorophenyl)piperazin-1-yl]ethyl]cyclohexyl]-1,1-dimethylurea

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27750 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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