CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM6907
Family Name 3-phosphoinositide-dependent protein kinase 1 and Rho-associated protein kinase 1 inhibitor SureCN1320418 family
No. of Seeds 12 No. of Other Members 11
Family Centroid CFAMM00347467 Functional Category Bioactive
Superfamily Insulin-like growth factor 1 receptor and Insulin receptor Binder Superfamily
Class Class 195

Cousin Family NamesSeedsMembers
Type-1 angiotensin II receptor Ligand Tasosartan Family 10 29
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
Corticotropin-releasing factor receptor 1 Ligand R121919 Family 26 84
Sodium channel protein type 1 subunit alpha and Sodium channel... 10 14
Xanthine dehydrogenase/oxidase Inhibitor 3,5-di(pyridin-4-yl)-... 6 3
RAC-gamma serine/threonine-protein kinase Inhibitor BMS-754807... 20 90
Sphingosine 1-phosphate receptor 1 ligand SureCN3029336 family 4 8
Tyrosine-protein kinase Lck and Tyrosine-protein kinase HCK in... 8 7
Smoothened homolog inhibitor SureCN1091571 family 2 2
Serine/threonine-protein kinase D1 and Polycystin-2 inhibitor ... 3 7
Polycystin-2 and Serine/threonine-protein kinase D1 inhibitor ... 4 12
Aurora kinase A and Aurora kinase B inhibitor 3uol family 6 5
DNA-dependent protein kinase catalytic subunit and Tyrosine-pr... 2 10
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 3 11
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 6 27
Adenosine receptor A2a ligand AGN-PC-077RWY family 4 5
Cellular tumor antigen p53 and Beta-lactamase inhibitor CHEMBL... 1 8
Survival motor neuron protein inhibitor CHEMBL1583999 family 1 3
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-09QM1E family 8 15
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 2 4
Receptor-type tyrosine-protein kinase FLT3 and Aurora kinase A... 3 5
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 2 2
Vascular endothelial growth factor receptor 1 and Vascular end... 4 0
Protein kinase C zeta type and Cyclin-dependent kinase 2 inhib... 2 13
Ribosomal protein S6 kinase beta-1 and RAC-alpha serine/threon... 2 1
Ribosomal protein S6 kinase beta-1 and RAC-alpha serine/threon... 4 0
Receptor-type tyrosine-protein kinase FLT3 ligand pyridin-3-yl... 2 1
Fibroblast growth factor receptor 1 and Vascular endothelial g... 5 0
Tyrosine-protein kinase BTK and Tyrosine-protein kinase ITK/TS... 4 0
Protein kinase C theta type and Protein kinase C delta type in... 9 0
Mast/stem cell growth factor receptor Kit and Proto-oncogene t... 3 5
Proto-oncogene tyrosine-protein kinase Src and Mast/stem cell ... 4 1
Tyrosine-protein kinase JAK2 inhibitor N-(3-methylphenyl)-5-(3... 2 4
Orexin receptor type 2 and Orexin receptor type 1 ligand 9-(4,... 4 0
Cyclin-dependent kinase 1 and Proto-oncogene tyrosine-protein ... 5 13
Casein kinase II subunit alpha inhibitor CHEMBL401945 family 12 1
Mitogen-activated protein kinase 14 inhibitor 3-[(6-amino-1-ph... 9 2
Serine/threonine-protein kinase Chk1 inhibitor N'-(8-chloro-3-... 1 1


External ID

Functional Category

Molecule Name

CFAMM00375617 CHEMBL1614777 Bioactive 3qd4
CFAMM00375616 CHEMBL1614776 Bioactive tert-butyl N-[(3R,6S)-1-[2-amino-6-(3-amino-1H-indazol-6-yl)pyrimidin-4-yl]-6-methylpiperidin-3-yl]carbamate
CFAMM00375609 CHEMBL1765744 Bioactive SureCN1318294
CFAMM00375622 CHEMBL1765738 Bioactive SureCN1316853
CFAMM00375608 CHEMBL1765743 Bioactive SureCN1316995
CFAMM00375607 CHEMBL1765742 Bioactive SureCN1318729
CFAMM00375620 CHEMBL1765750 Bioactive tert-butyl N-[(3R,5R)-1-[6-(3-amino-1H-indazol-6-yl)-2-(methylamino)pyrimidin-4-yl]-5-methylpiperidin-3-yl]-N-methylcarbamate
CFAMM00375606 CHEMBL1765740 Bioactive GSK2334470

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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