CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM6908
Family Name Coagulation factor X inhibitor 6-chloro-N-[(3S)-1-[4-[1-(ethylamino)ethyl]-2-fluorophenyl]-2-oxopyrrolidin-3-yl]naphthalene-2-sulfonamide family
No. of Seeds 27 No. of Other Members 1
Family Centroid CFAMM00375641 Functional Category Bioactive
Superfamily Coagulation factor X and 5-hydroxytryptamine receptor 6 Binder Superfamily
Class Class 3169

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 6 ligand 1-(5-chloronaphthalen-1-... 1 5
Prothrombin inhibitor (2S)-N-[[2-(aminomethyl)-5-chlorophenyl]... 5 11
Coagulation factor X inhibitor 1-(6-chloronaphthalen-2-yl)sulf... 12 13
Coagulation factor X inhibitor (2S)-N-(3-aminopropyl)-2-[(3S)-... 22 15
Coagulation factor X inhibitor 2-[(6-chloronaphthalen-2-yl)sul... 10 2
Coagulation factor X inhibitor (E)-2-(5-chlorothiophen-2-yl)-N... 6 1
Coagulation factor X inhibitor SureCN4463987 family 5 0
Prothrombin and Proteinase-activated receptor 1 ligand (2S)-N-... 2 4


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00375635 CHEMBL1614872 Bioactive 6-chloro-N-[(3S)-1-[(1S)-1-(dimethylamino)-2,3-dihydro-1H-inden-5-yl]-2-oxopyrrolidin-3-yl]naphthalene-2-sulfonamide
CFAMM00375648 CHEMBL606135 Bioactive 6-chloro-N-[(3S)-1-[4-[1-(dimethylamino)ethyl]-2-fluorophenyl]-2-oxopyrrolidin-3-yl]naphthalene-2-sulfonamide
CFAMM00375628 CHEMBL1614819 Bioactive 6-chloro-N-[(3S)-1-[2-fluoro-4-[(2R)-pyrrolidin-2-yl]phenyl]-2-oxopyrrolidin-3-yl]naphthalene-2-sulfonamide
CFAMM00375641 CHEMBL593585 Bioactive 6-chloro-N-[(3S)-1-[4-[1-(ethylamino)ethyl]-2-fluorophenyl]-2-oxopyrrolidin-3-yl]naphthalene-2-sulfonamide
CFAMM00375634 CHEMBL1614790 Bioactive 6-chloro-N-[(3S)-1-[(1R)-1-(dimethylamino)-2,3-dihydro-1H-inden-5-yl]-2-oxopyrrolidin-3-yl]naphthalene-2-sulfonamide
CFAMM00375647 CHEMBL605294 Bioactive 6-chloro-N-[(3S)-1-[2-fluoro-4-[(1S)-1-(methylamino)ethyl]phenyl]-2-oxopyrrolidin-3-yl]naphthalene-2-sulfonamide
CFAMM00375627 CHEMBL1684189 Bioactive 6-chloro-N-[(3S)-1-(2-fluoro-4-pyrrolidin-2-ylphenyl)-2-oxopyrrolidin-3-yl]naphthalene-2-sulfonamide
CFAMM00375640 CHEMBL593586 Bioactive 6-chloro-N-[(3S)-1-[2-fluoro-4-[1-(propan-2-ylamino)ethyl]phenyl]-2-oxopyrrolidin-3-yl]naphthalene-2-sulfonamide
CFAMM00375633 CHEMBL1684187 Bioactive 6-chloro-N-[(3S)-1-[2-fluoro-4-(1-methylpyrrolidin-2-yl)phenyl]-2-oxopyrrolidin-3-yl]naphthalene-2-sulfonamide
CFAMM00375626 CHEMBL594313 Bioactive SureCN5375578
CFAMM00375639 CHEMBL604887 Bioactive N-[(3S)-1-[4-[1-(azetidin-1-yl)ethyl]-2-fluorophenyl]-2-oxopyrrolidin-3-yl]-6-chloronaphthalene-2-sulfonamide
CFAMM00375632 CHEMBL1684185 Bioactive SureCN5436451
CFAMM00375645 CHEMBL594598 Bioactive SureCN5395896
CFAMM00375625 CHEMBL593829 Bioactive 6-chloro-N-[(3S)-1-[2-fluoro-4-[(1R)-1-(methylamino)ethyl]phenyl]-2-oxopyrrolidin-3-yl]naphthalene-2-sulfonamide
CFAMM00375638 CHEMBL1689030 Bioactive SureCN4638355
CFAMM00375631 CHEMBL1684183 Bioactive SureCN5431361
CFAMM00375644 CHEMBL594538 Bioactive 6-chloro-N-[(3S)-1-[2-fluoro-4-[1-[methyl(propan-2-yl)amino]ethyl]phenyl]-2-oxopyrrolidin-3-yl]naphthalene-2-sulfonamide
CFAMM00375624 CHEMBL606812 Bioactive 6-chloro-N-[(3S)-1-[2-fluoro-4-(1-piperidin-1-ylethyl)phenyl]-2-oxopyrrolidin-3-yl]naphthalene-2-sulfonamide
CFAMM00375637 CHEMBL1615104 Bioactive SureCN4179691
CFAMM00375650 CHEMBL1689021 Bioactive SureCN8259278
CFAMM00375630 CHEMBL1684180 Bioactive SureCN14372349
CFAMM00375643 CHEMBL594539 Bioactive 6-chloro-N-[(3S)-1-[2-fluoro-4-(1-pyrrolidin-1-ylethyl)phenyl]-2-oxopyrrolidin-3-yl]naphthalene-2-sulfonamide
CFAMM00375636 CHEMBL1689015 Bioactive SureCN4176676
CFAMM00375649 CHEMBL1689027 Bioactive SureCN4932363
CFAMM00375623 CHEMBL606699 Bioactive 6-chloro-N-[(3S)-1-[4-[1-[ethyl(methyl)amino]ethyl]-2-fluorophenyl]-2-oxopyrrolidin-3-yl]naphthalene-2-sulfonamide
CFAMM00375629 CHEMBL1614818 Bioactive 6-chloro-N-[(3S)-1-[2-fluoro-4-[(2S)-pyrrolidin-2-yl]phenyl]-2-oxopyrrolidin-3-yl]naphthalene-2-sulfonamide
CFAMM00375642 CHEMBL1689019 Bioactive SureCN4183599

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27515 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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