CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM6913
Family Name Tyrosine-protein kinase JAK2 inhibitor AGN-PC-09QJGR family
No. of Seeds 3 No. of Other Members 13
Family Centroid CFAMM00375667 Functional Category Bioactive
Superfamily Adenosine receptor A1 and Adenosine receptor A2a Binder Superfamily 13
Class Class 855

Cousin Family NamesSeedsMembers
Corticotropin-releasing factor receptor 1 Ligand CRF-1 Antagon... 29 421
Tyrosine-protein kinase Lck and Aurora kinase B Inhibitor VX-6... 28 56
Corticotropin-releasing factor receptor 1 Ligand GW876008 Family 3 30
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
DCC-2036 family 2 5
Hepatocyte growth factor receptor Ligand Amg 208 Family 20 236
Vascular endothelial growth factor receptor 2 Ligand L00002164... 6 23
Angiopoietin-1 receptor and Tyrosine-protein kinase Lck Inhibi... 4 32
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 4 Inhibi... 19 48
Reverse transcriptase Inhibitor Atevirdine Family 4 55
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 2 31
Reverse transcriptase Inhibitor UK-129485 Family 23 221
RAC-gamma serine/threonine-protein kinase Inhibitor BMS-754807... 20 90
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 1 6
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 6 35
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 28
Sphingosine 1-phosphate receptor 1 ligand SureCN3029336 family 4 8
Adenosine receptor A3 ligand AGN-PC-07N4XZ family 4 11
Serine/threonine-protein kinase PLK1 and Serine/threonine-prot... 14 42
Adenosine receptor A3 ligand CHEMBL1834696 family 5 18
Muscarinic acetylcholine receptor M2 and Muscarinic receptor 3... 4 3
Platelet-activating factor receptor ligand SureCN9384429 family 11 3
Serine/threonine-protein kinase D1 and Polycystin-2 inhibitor ... 3 7
Adenosine receptor A1 and Adenosine receptor A3 ligand AGN-PC-... 4 3
Cellular tumor antigen p53 inhibitor CHEMBL1401545 family 1 25
Thyroid hormone receptor beta and Ferritin light chain ligand ... 1 35
Thyroid hormone receptor beta and Cruzipain ligand CHEMBL14730... 1 12
Insulin-like growth factor 1 receptor ligand AGN-PC-09QGLU family 3 1
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-09QM1E family 8 15
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-07CBUP family 2 3
Melatonin receptor type 1B ligand CHEMBL1802020 family 2 7
Tyrosine-protein kinase JAK2 inhibitor (2S)-1-[4-[4-[[7-(2-met... 11 27
Protein-tyrosine kinase 6 and KH domain-containing, RNA-bindin... 21 6
Serine/threonine-protein kinase RIO2 and Serine/threonine-prot... 19 10
Serine/threonine-protein kinase RIO2 and Serine/threonine-prot... 12 13
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 3 10
Tyrosine-protein kinase JAK2 and Focal adhesion kinase 1 inhib... 3 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 2
Mitogen-activated protein kinase 14 inhibitor AGN-PC-075YLX fa... 3 1
Serine/threonine-protein kinase TBK1 and Inhibitor of nuclear ... 2 8
DNA gyrase subunit B inhibitor N-ethyl-5-[6-methoxy-5-(2-oxo-3... 3 0
Casein kinase II subunit alpha inhibitor N-[5-[[3-cyano-7-(cyc... 3 0
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 25 2
Growth hormone secretagogue receptor type 1 ligand SureCN36800... 14 42
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 0
Rho-associated protein kinase 1 inhibitor SureCN4007647 family 8 4
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 6 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 3 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 1
Glycogen synthase kinase-3 beta and Casein kinase I isoform ga... 3 0
Vascular endothelial growth factor receptor 2 and Serine/threo... 6 13
Receptor tyrosine-protein kinase erbB-2 ligand SureCN4461871 f... 2 2
Mast/stem cell growth factor receptor Kit and Epithelial disco... 3 0
Adenosine receptor A2a and Cytochrome P450 3A4 ligand N-[6-(3,... 5 2
Tyrosine-protein kinase SYK inhibitor N-tert-butyl-2-[5-(diflu... 7 0
Tyrosine-protein kinase JAK3 and Tyrosine-protein kinase JAK2 ... 1 0
Aurora kinase B and Aurora kinase A inhibitor 2-fluoro-6-metho... 2 0
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 1
Serine/threonine-protein kinase PLK4 inhibitor (3E)-5-methoxy-... 4 0
Tyrosine-protein kinase JAK2 inhibitor (2R)-2-[4-[[8-(4-methox... 2 0
Adenosine receptor A3 and Adenosine receptor A1 ligand 2-pheny... 9 2
Adenosine receptor A2a ligand 8-(3-fluorophenyl)-3-[2-[4-[4-(2... 5 0
Cyclin-dependent kinase 1 inhibitor N-[[5-[(3Z)-3-[4-(methoxym... 3 7
Hepatocyte growth factor receptor ligand AGN-PC-00AG7Q family 1 10
C-X-C chemokine receptor type 3 ligand N-[(1R)-1-[1-(4-ethoxyp... 5 9
Mitogen-activated protein kinase 14 inhibitor 3-[(6-amino-1-ph... 9 2
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 6 0
Adenosine receptor A2b and Adenosine receptor A1 ligand N-(3,4... 1 8
Adenosine receptor A3 and Adenosine receptor A1 ligand N-[2-(4... 3 2
Cyclin-dependent kinase 1 and Receptor tyrosine-protein kinase... 2 3
Glycogen synthase kinase-3 beta and Glycogen synthase kinase-3... 4 4
Coagulation factor X inhibitor SureCN5641901 family 5 0
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 7 5
Oxytocin receptor and Vasopressin V1a receptor ligand AGN-PC-0... 4 3
Adenosine receptor A2a ligand AGN-PC-077RYH family 16 5
Adenosine receptor A3 and Adenosine receptor A1 ligand CHEMBL4... 2 3
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 15 1
Adenosine receptor A2b and Adenosine receptor A1 ligand N-[(3Z... 2 2
Adenosine receptor A2b and Adenosine receptor A1 ligand 8-[1-[... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00375679 CHEMBL1682377 Bioactive AGN-PC-09QHPO
CFAMM00375676 CHEMBL1615027 Bioactive SureCN1722921
CFAMM00375667 CHEMBL1682385 Bioactive AGN-PC-09QJGR

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

46143 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543