| Cousin Family Names | Seeds | Members |
|---|
| 5-hydroxytryptamine receptor 2C ligand Tetracyclic antidepress... | 14 | 498 |
| Alpha-2 adrenergic receptor Ligand Dexmedetomidine Family | 32 | 639 |
| Toll-like receptor 7 Ligand Imiquimod Family | 3 | 237 |
| Alpha-2A adrenergic receptor Ligand Brimonidine Family | 3 | 6 |
| Amiloride-sensitive sodium channel subunit alpha Ligand Triamt... | 8 | 98 |
| Peptide deformylase, mitochondrial Inhibitor Pyrimethamine Family | 10 | 145 |
| Histamine H1 receptor Ligand Emedastine Family | 5 | 115 |
| Histamine H1 receptor Ligand Mizolastine Family | 14 | 603 |
| Metabotropic glutamate receptor 5 Ligand ADX-48621 Family | 15 | 444 |
| C-X-C chemokine receptor type 4 Ligand AMD-070 Family | 12 | 800 |
| Transient receptor potential cation channel subfamily V member... | 15 | 457 |
| Vascular endothelial growth factor Inhibitor PTC299 Family | 6 | 145 |
| Cyclin-dependent kinase 2 Inhibitor Seliciclib Family | 29 | 292 |
| Fibroblast growth factor receptor 2 and Fibroblast growth fact... | 11 | 86 |
| Cyclin-dependent kinase 4 Inhibitor PD-332991 Family | 13 | 155 |
| Cannabinoid receptor 1 Ligand CP-945598 Family | 18 | 173 |
| Reverse transcriptase Inhibitor Dapivirine Family | 5 | 72 |
| Translocator protein Inhibitor Emapunil Family | 7 | 89 |
| 5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... | 14 | 234 |
| Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family | 53 | 580 |
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... | 35 | 270 |
| Genomic RNA for RNA-dependent RNA polymerase gene (clone HCV-J... | 13 | 55 |
| GDC-0349 family | 44 | 77 |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... | 8 | 55 |
| Corticotropin-releasing factor receptor 1 Ligand CP-154526 Family | 9 | 29 |
| Tryptase Inhibitor Babim Family | 12 | 90 |
| D(4) dopamine receptor Ligand L-745,870 Family | 30 | 205 |
| 5-hydroxytryptamine receptor 2B Ligand MT-500 Family | 8 | 39 |
| Corticotropin-releasing factor receptor 1 Ligand R121919 Family | 26 | 84 |
| Beta-secretase 1 Inhibitor 6-[2-(1h-indol-6-yl)ethyl]pyridin-2... | 10 | 43 |
| Beta-secretase 1 Inhibitor N~3~-(3-pyridin-3-ylbenzyl)pyridine... | 31 | 66 |
| Adenosine receptor A1 and Adenosine receptor A2a Ligand 2,6-di... | 13 | 14 |
| 5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... | 4 | 32 |
| Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... | 18 | 109 |
| Vascular endothelial growth factor receptor 1 and Vascular end... | 6 | 23 |
| Peptide deformylase, mitochondrial Inhibitor 5-phenethyl-quina... | 5 | 14 |
| Serine/threonine-protein kinase B-raf Inhibitor 2-(benzylamino... | 7 | 117 |
| Epidermal growth factor receptor Ligand PD-158780 Family | 98 | 89 |
| Adenosine receptor A2a and Adenosine receptor A3 Ligand 5-buty... | 3 | 18 |
| Cyclin-dependent kinase 4 Inhibitor 1-pyridin-2-yl-3-quinolin-... | 2 | 5 |
| Arachidonate 5-lipoxygenase Inhibitor 2,4,5-triarylimidazole A... | 3 | 16 |
| Methionine aminopeptidase 2 Inhibitor 2-(pyridin-2-yl)-1h-benz... | 6 | 19 |
| Scytalone dehydratase Inhibitor Isoquinolin-1-yl-(3-phenyl-pro... | 4 | 9 |
| Epidermal growth factor receptor Ligand (3-bromo-phenyl)-quina... | 7 | 5 |
| Metabotropic glutamate receptor 5 Ligand 3-(4-pyridin-2-yl-imi... | 6 | 5 |
| Cyclin-dependent kinase 1 Inhibitor CGP-60474 Family | 14 | 103 |
| Adenosine receptor A1 Ligand Phenyl-(9-phenyl-9h-purin-6-yl)-a... | 7 | 12 |
| Mitogen-activated protein kinase 3 and RAF proto-oncogene seri... | 8 | 5 |
| Histamine H3 receptor Ligand 2-(4-isopropyl-piperazin-1-yl)-qu... | 17 | 29 |
| RAC-gamma serine/threonine-protein kinase and Rho-associated p... | 16 | 46 |
| Adenosine receptor A3 and Dual specificity mitogen-activated p... | 5 | 27 |
| Metabotropic glutamate receptor 5 Ligand 2-m-tolyl-1,8-naphthy... | 7 | 11 |
| Adenosine receptor A3 Ligand 2-(5-chloro-1h-benzo[d]imidazol-2... | 7 | 51 |
| Adenosine receptor A3 Ligand 2-(4-nitro-1h-benzo[d]imidazol-2-... | 2 | 12 |
| Cyclin-dependent kinase 2 and Mitogen-activated protein kinase... | 7 | 30 |
| Adenosine receptor A3 Ligand 1-(2-(diethylamino)quinazolin-4-y... | 2 | 9 |
| Mitogen-activated protein kinase 14 and Tyrosine-protein kinas... | 3 | 9 |
| Cathepsin K Inhibitor 2-cyclohexylamino-pyridine-2-carbonitril... | 1 | 2 |
| Adenosine receptor A1 and Adenosine receptor A2a Ligand N-(2,6... | 22 | 18 |
| Proto-oncogene tyrosine-protein kinase Src Inhibitor BMS-27970... | 41 | 59 |
| Cathepsin K Inhibitor 4-phenyl-6-propylpyrimidine-2-carbonitri... | 6 | 10 |
| Adenosine receptor A1 and Adenosine receptor A2a Ligand 4-amin... | 4 | 11 |
| Fatty-acid amide hydrolase 1 Inhibitor JNJ-1661010 Family | 3 | 14 |
| Aromatase Inhibitor NSC-356781 Family | 3 | 10 |
| Macrophage migration inhibitory factor Inhibitor 4-iodo-6-phen... | 5 | 4 |
| Oestrogen receptor Ligand 4-benzyl-2,6-diisobutylamino-pyrimid... | 5 | 37 |
| Histamine H4 receptor Ligand A-943931 Family | 14 | 11 |
| RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... | 219 | 124 |
| Farnesyl pyrophosphate synthase Inhibitor [2-(benzoimidazol-1-... | 2 | 16 |
| Potassium voltage-gated channel subfamily H member 2 Ligand AZ... | 21 | 42 |
| Glycogen synthase kinase-3 beta Inhibitor CHIR-98023 Family | 5 | 6 |
| Glycogen synthase kinase-3 beta Inhibitor 4-(5-bromo-1h-indol-... | 7 | 18 |
| Cytochrome P450 11B1, mitochondrial Inhibitor 1-(4-bromobenzyl... | 3 | 0 |
| Histamine H3 receptor Ligand 4-(2-(phenylamino)ethyl)-1h-imida... | 5 | 16 |
| Urotensin-2 receptor Ligand Palosuran Family | 4 | 4 |
| Sodium-dependent serotonin transporter Inhibitor 6-nitroquipaz... | 18 | 21 |
| Peptide deformylase, mitochondrial Inhibitor 6-phenylsulfanylm... | 2 | 3 |
| Type-2 angiotensin II receptor Ligand L-158809 Family | 22 | 136 |
| Proto-oncogene tyrosine-protein kinase Src Inhibitor CGP-62464... | 3 | 10 |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... | 4 | 22 |
| Sodium-dependent serotonin transporter Inhibitor 6-chloro-2-pi... | 5 | 35 |
| Sodium channel protein type 1 subunit alpha and Sodium channel... | 10 | 14 |
| Metabotropic glutamate receptor 5 Ligand 2-methyl-7-m-tolyl-1,... | 5 | 2 |
| Acetylcholinesterase Inhibitor N-benzyl-2-morpholinopyrimidin-... | 6 | 16 |
| Nitric oxide synthase, inducible and Nitric oxide synthase, br... | 1 | 4 |
| Protein kinase C alpha type Inhibitor Dequalinium Analogue Family | 1 | 10 |
| Adenosine receptor A3 and Adenosine receptor A2a ligand 5-buty... | 3 | 13 |
| Corticotropin-releasing factor receptor 1 ligand 3-(2-bromo-4-... | 13 | 34 |
| Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... | 14 | 4 |
| cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... | 4 | 2 |
| Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... | 10 | 3 |
| cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... | 34 | 11 |
| cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN5... | 6 | 24 |
| Platelet-activating factor receptor ligand AGN-PC-0750SP family | 4 | 0 |
| 5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... | 7 | 4 |
| Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... | 7 | 10 |
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... | 4 | 27 |
| Epidermal growth factor receptor ligand AGN-PC-076GVG family | 8 | 1 |
| Epidermal growth factor receptor ligand pyrido[4,3-d]pyrimidin... | 11 | 0 |
| Cathepsin K and Potassium voltage-gated channel subfamily H me... | 3 | 1 |
| Type-1B angiotensin II receptor ligand SureCN683399 family | 3 | 0 |
| Sorbitol dehydrogenase inhibitor SureCN6335187 family | 2 | 6 |
| Cellular tumor antigen p53 and Beta-lactamase inhibitor CHEMBL... | 1 | 8 |
| Histamine H4 receptor ligand 2-[[6-iodo-2-(4-methylpiperazin-1... | 4 | 2 |
| D(4) dopamine receptor and D(2) dopamine receptor ligand 4-met... | 13 | 8 |
| Nociceptin receptor and Kappa-type opioid receptor ligand 1-[1... | 4 | 4 |
| Dihydrofolate reductase and Bifunctional dihydrofolate reducta... | 5 | 0 |
| Metabotropic glutamate receptor 1 and Metabotropic glutamate r... | 2 | 2 |
| Adenosine receptor A3 and Adenosine receptor A1 ligand (8R)-8-... | 4 | 0 |
| Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... | 3 | 7 |
| Corticotropin-releasing factor receptor 1 ligand SureCN6301726... | 4 | 1 |
| Glutamate receptor ionotropic, NMDA 2D and Glutamate receptor ... | 3 | 3 |
| Toll-like receptor 7 ligand 6-amino-2-(butylamino)-9-[[4-(dime... | 5 | 4 |
| Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... | 1 | 2 |
| Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... | 1 | 1 |
| Melanin-concentrating hormone receptor 1 ligand SureCN3334191 ... | 4 | 7 |
| Signal transducer and activator of transcription 6 inhibitor A... | 3 | 0 |
| Histamine H4 receptor ligand 4-[(3R)-3-(methylamino)pyrrolidin... | 7 | 6 |
| Neuropeptide Y receptor type 5 ligand SureCN8898853 family | 2 | 3 |
| Mu-type opioid receptor and Kappa-type opioid receptor ligand ... | 3 | 0 |
| Corticotropin-releasing factor receptor 1 ligand 8-[butyl(ethy... | 2 | 6 |
| High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A ... | 1 | 1 |
| Ribosomal protein S6 kinase alpha-5 inhibitor AGN-PC-075HAD fa... | 2 | 0 |
| Histamine H4 receptor and Histamine H3 receptor ligand (E)-[(3... | 4 | 3 |
| cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... | 2 | 0 |
| Tyrosine-protein kinase JAK1 inhibitor CHEMBL2206623 family | 10 | 11 |
| Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... | 2 | 2 |
| D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... | 3 | 0 |
| Ketohexokinase inhibitor 4-N-(2-methylsulfanylphenyl)-2-pipera... | 6 | 23 |
| Transient receptor potential cation channel subfamily V member... | 4 | 0 |
| Epidermal growth factor receptor and Receptor tyrosine-protein... | 8 | 4 |
| Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... | 3 | 0 |
| Cannabinoid receptor 2 ligand 8-(2-chlorophenyl)-9-cyclopropyl... | 4 | 5 |
| D(4) dopamine receptor and Alpha-1D adrenergic receptor ligand... | 3 | 3 |
| D(4) dopamine receptor and D(3) dopamine receptor ligand AGN-P... | 2 | 0 |
| Tyrosine-protein kinase JAK1 inhibitor CHEMBL2152398 family | 16 | 1 |
| Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... | 6 | 2 |
| Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... | 2 | 1 |
| Tyrosine-protein kinase JAK1 inhibitor CHEMBL2206614 family | 2 | 0 |
| Mitogen-activated protein kinase 14 inhibitor 6-[2-(2,6-difluo... | 3 | 0 |
| Adenosine receptor A1 ligand N-butyl-5-phenyl-3-[[2-(trifluoro... | 7 | 2 |
| Tyrosine-protein kinase JAK1 and Aurora kinase A inhibitor CHE... | 2 | 0 |
| CGMP-dependent protein kinase inhibitor SureCN14561191 family | 4 | 0 |
| Cholinesterase inhibitor 4-[4,5-diphenyl-1-[7-(1,2,3,4-tetrahy... | 2 | 1 |
| Motilin receptor ligand SureCN2004322 family | 2 | 1 |
| Histamine H4 receptor and Histamine H3 receptor ligand 7-cyclo... | 2 | 0 |
| Serine/threonine-protein kinase mTOR inhibitor 1-ethyl-3-[4-[6... | 4 | 1 |
| Cathepsin K inhibitor SureCN4141224 family | 3 | 0 |
| Nociceptin receptor and Potassium voltage-gated channel subfam... | 5 | 2 |
| LIM domain kinase 2 inhibitor (2S)-N-cyano-N'-(3-cyanophenyl)-... | 4 | 0 |
| D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... | 2 | 2 |
| Adenosine receptor A1 and Adenosine receptor A2b ligand SureCN... | 2 | 3 |
| Epidermal growth factor receptor ligand AGN-PC-078X7L family | 4 | 0 |
| Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... | 2 | 0 |
| Type-1 angiotensin II receptor ligand SureCN7390271 family | 2 | 1 |
| Gonadotropin-releasing hormone receptor ligand 4-[[4-[2-(4-ter... | 3 | 3 |
| Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... | 7 | 0 |
| 5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... | 4 | 0 |
| Metabotropic glutamate receptor 1 ligand AGN-PC-00FV3S family | 2 | 0 |
| Cyclin-dependent kinase 2 inhibitor SureCN3549598 family | 3 | 1 |
| Nociceptin receptor and Mu-type opioid receptor ligand 2-(3-ch... | 2 | 0 |
| Ribosomal protein S6 kinase beta-1 and Aurora kinase B inhibit... | 1 | 5 |
| 5-hydroxytryptamine receptor 3A ligand AGN-PC-077D8K family | 3 | 1 |
| Tyrosine-protein kinase Lck inhibitor (3S)-3-[(1S)-1-[[4-(benz... | 14 | 0 |
| LIM domain kinase 1 and LIM domain kinase 2 inhibitor (2S)-N'-... | 9 | 0 |
| Dihydrofolate reductase type 1 and Dihydrofolate reductase inh... | 1 | 0 |
| D(4) dopamine receptor and D(2) dopamine receptor ligand SureC... | 1 | 2 |
| Adenosine receptor A1 and Adenosine receptor A2a ligand 2-(2-c... | 2 | 0 |
| Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... | 1 | 5 |
| Microtubule-associated protein tau and Thyrotropin receptor li... | 1 | 2 |
| Corticotropin-releasing factor receptor 1 ligand 5-N,5-N-bis(c... | 2 | 0 |
| 5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... | 1 | 2 |
| 5-hydroxytryptamine receptor 3A and Histamine H4 receptor liga... | 1 | 0 |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... | 1 | 0 |
| Induced myeloid leukemia cell differentiation protein Mcl-1 an... | 1 | 0 |
Statistics of CFAM Database |
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
|
How to cite our database |
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C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering.
Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
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Last update by |
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2014.08.29
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