CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM6920
Family Name Thyroid hormone receptor beta and Thyroid hormone receptor alpha ligand CGS-23425 family
No. of Seeds 11 No. of Other Members 26
Family Centroid CFAMM00375741 Functional Category Bioactive with Natural Product
Superfamily Thyroid hormone receptor beta and Thyroid hormone receptor alpha Binder Superfamily 2
Class Class 4476

Cousin Family NamesSeedsMembers
D(4) dopamine receptor Ligand PD-165167 Family 2 96
Dihydroorotate dehydrogenase and Interleukin-17A Inhibitor Vid... 4 74
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Cilost... 6 202
Amine oxidase [flavin-containing] A Inhibitor Ethyl 4-(2-oxo-2... 4 117
Mineralocorticoid receptor and Androgen receptor Ligand AL-43 ... 79 235
Cytochrome P450 1B1 Inhibitor N-(2,4-dimethoxy-phenyl)-3,5-dim... 1 110
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor N-(4-(... 7 18
Amine oxidase [flavin-containing] B Inhibitor N-methyl-n-pheny... 6 25
Neuropeptide S receptor and Prelamin-A/C ligand CHEMBL1352632 ... 1 25
Thyroid hormone receptor beta ligand SureCN8800248 family 3 10
Thyroid hormone receptor beta ligand 169799-03-5 family 2 6
Thyroid hormone receptor beta ligand SureCN8892696 family 2 7
Thyroid hormone receptor beta ligand SureCN8799519 family 5 0
Histone deacetylase 6 and Histone deacetylase 1 inhibitor AGN-... 6 11
Thyroid hormone receptor beta ligand SureCN8799630 family 4 0
Androgen receptor ligand AGN-PC-00BRQF family 2 2
Thyroid hormone receptor beta and Thyroid hormone receptor alp... 4 2
Thyroid hormone receptor beta and Thyroid hormone receptor alp... 1 0
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 1 0
Acyl-CoA:cholesterol acyltransferase inhibitor [2,6-di(propan-... 2 0
Amine oxidase [flavin-containing] B and Adenosine receptor A2b... 2 2
N-(4-acetamidophenyl)-2-(2,2-dimethyl-3,4-dihydrochromen-6-yl)... 1 0


External ID

Functional Category

Molecule Name

CFAMM00375741 CHEMBL46882 Bioactive CGS-23425
CFAMM00375768 CHEMBL350199 Bioactive SureCN8798929
CFAMM00375740 CHEMBL163020 Bioactive SureCN8799175
CFAMM00375773 CHEMBL350049 Bioactive SureCN8798722
CFAMM00375745 CHEMBL2035881 Bioactive 2-[[7-(4-hydroxy-3-propan-2-ylphenoxy)-6-methyl-2,3-dihydro-1H-inden-4-yl]amino]-2-oxoacetic acid
CFAMM00375758 CHEMBL264041 Bioactive SureCN8799460
CFAMM00375749 CHEMBL608990 Bioactive SureCN1641794
CFAMM00375763 CHEMBL163221 Bioactive SureCN7151397
CFAMM00375769 CHEMBL161535 Bioactive SureCN7094647
CFAMM00375762 CHEMBL164421 Bioactive benzyl 2-[4-(4-hydroxy-3-propan-2-ylphenoxy)-3,5-dimethylanilino]-2-oxoacetate

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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