CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM6927
Family Name Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[(1-benzyl-5-oxopyrrolidine-2-carbonyl)amino]-3-[4-[[4-fluoro-2-(trifluoromethyl)benzoyl]amino]phenyl]propanoic acid family
No. of Seeds 5 No. of Other Members 2
Family Centroid CFAMM00375800 Functional Category Bioactive
Superfamily Integrin beta-3 Inhibitor Lotrafiban Superfamily
Class Class 1675

Cousin Family NamesSeedsMembers
Angiotensin-converting enzyme Inhibitor Benazepril Family 7 123
Integrin beta-1 Inhibitor R411 Family 33 44
Kappa-type opioid receptor Ligand Asimadoline Family 14 54
Dual specificity mitogen-activated protein kinase kinase Inhib... 7 69
Potassium voltage-gated channel subfamily A member 5 Ligand S-... 34 206
Integrin alpha-4 Inhibitor BIO-1211 Family 16 83
Vasopressin V1a receptor and Vasopressin V2 receptor Ligand OP... 12 94
Farnesyltransferase beta subunit, putative and Protein farnesy... 24 82
Plasmepsin-2 Inhibitor PS-222036 Family 12 134
Integrin beta-3 Inhibitor L-767679 Family 3 6
Integrin beta-3 Inhibitor L-750034 Family 7 38
Integrin beta-3 Inhibitor SB-208651 Family 9 28
Integrin beta-3 Inhibitor Lotrafiban Family 5 1
Cholecystokinin receptor type A Ligand VL-1499 Family 12 133
Integrin alpha-2 and Integrin beta-3 Inhibitor 3-(3-(carbamoyl... 7 13
Beta-secretase 1 and Cathepsin D Inhibitor GRL-7234 Family 17 148
Beta-secretase 1 Inhibitor KMI-538 Family 4 20
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 6 24
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 14 110
Beta-secretase 1 Inhibitor GSK-188909 Family 16 11
5-hydroxytryptamine receptor 7 Ligand UCM-5600 Family 15 46
Vasopressin V2 receptor Ligand VA-106483 Family 16 115
72 kDa type IV collagenase and Stromelysin-1 inhibitor [(2S)-2... 9 6
Caspase-1 inhibitor CHEMBL114791 family 1 0
Angiotensin-converting enzyme inhibitor (2R)-1-[4-carboxy-4-(p... 3 3
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[(2S)-1... 6 6
Integrin beta-3 and Integrin alpha-IIb inhibitor SureCN7345980... 4 6
Prostaglandin E2 receptor EP4 subtype ligand SureCN3567929 family 10 3
Stromelysin-1 and 72 kDa type IV collagenase inhibitor (2R)-2-... 2 1
Stromelysin-1 inhibitor 6-(4'-FLUORO-BIPHENYL-4-YL)-4-(3-METHY... 3 0
Chymase and Chymotrypsin-C inhibitor 3-[[2,2-difluoro-4-[[(2S)... 6 10
Integrin beta-1 and Integrin alpha-4 inhibitor 4-[[1-[2-[4-[(2... 2 8
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 3 5
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-1-... 3 3
Cathepsin D and Cathepsin E inhibitor methyl (2S)-1-[(2R)-2-[[... 1 0
C-C chemokine receptor type 3 ligand 1-(3-acetylphenyl)-3-[3-[... 9 1
Angiotensin-converting enzyme inhibitor 1-[(2R,4R)-4-carboxy-2... 2 3
Mitogen-activated protein kinase 14 inhibitor ethyl 2-[[3-(2,4... 4 0
Mitogen-activated protein kinase 14 inhibitor 3-(3-benzamido-4... 2 0
Mitogen-activated protein kinase 14 inhibitor 3-(2,4-difluoroa... 6 0
Integrin beta-3 and Integrin alpha-V inhibitor AGN-PC-037CNR f... 5 8
Atrial natriuretic peptide receptor 1 and Atrial natriuretic p... 3 0
Integrin beta-1 and Integrin alpha-4 inhibitor SureCN6373390 f... 2 0
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[(1-benz... 1 0
Integrin beta-3 and Integrin alpha-IIb inhibitor AGN-PC-009EMK... 2 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00375799 CHEMBL349077 Bioactive (2S)-2-[(1-benzyl-5-oxopyrrolidine-2-carbonyl)amino]-3-[4-[(3-cyanobenzoyl)amino]phenyl]propanoic acid
CFAMM00375804 CHEMBL162004 Bioactive (2S)-2-[(1-benzyl-5-oxopyrrolidine-2-carbonyl)amino]-3-[4-[(2-methyl-5-nitrobenzoyl)amino]phenyl]propanoic acid
CFAMM00375803 CHEMBL351845 Bioactive (2S)-2-[[(2S)-1-benzyl-5-oxopyrrolidine-2-carbonyl]amino]-3-[4-[(4-nitrobenzoyl)amino]phenyl]propanoic acid
CFAMM00375802 CHEMBL347839 Bioactive (2S)-2-[(1-benzyl-5-oxopyrrolidine-2-carbonyl)amino]-3-[4-[[2,5-bis(trifluoromethyl)benzoyl]amino]phenyl]propanoic acid
CFAMM00375800 CHEMBL161901 Bioactive (2S)-2-[(1-benzyl-5-oxopyrrolidine-2-carbonyl)amino]-3-[4-[[4-fluoro-2-(trifluoromethyl)benzoyl]amino]phenyl]propanoic acid

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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