CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM6948
Family Name cAMP-specific 3',5'-cyclic phosphodiesterase 4A inhibitor SureCN7906644 family
No. of Seeds 14 No. of Other Members 8
Family Centroid CFAMM00376019 Functional Category Bioactive
Superfamily Beta-secretase 1 and Beta-secretase 2 Binder Superfamily 4
Class Class 513

Cousin Family NamesSeedsMembers
Epidermal growth factor receptor Ligand Gefitinib Family 26 600
Peptide deformylase, mitochondrial Inhibitor Trimethoprim Family 67 482
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741
Histamine H1 receptor Ligand Mepyramine Family 5 65
Hypoxia-inducible factor 1-alpha Inhibitor Hif-1alpha Family 7 107
Melanin-concentrating hormone receptor 1 Ligand NGD-4715 Family 1 1
Insulin-like growth factor 1 receptor Ligand AEW-541 Family 12 140
Calcium-activated potassium channel subunit alpha-1 Ligand AVE... 3 284
Smoothened homolog Inhibitor LDE225 Family 3 76
5-hydroxytryptamine receptor 1B Ligand GR55562 Family 3 45
5-hydroxytryptamine receptor 1A Ligand P-MPPI Family 33 81
Tissue-type plasminogen activator Inhibitor N-(7-benzyloxy-iso... 4 37
Hemoglobin subunit alpha Inhibitor 2-[(2-methoxy-5-methylpheno... 5 48
Estradiol 17-beta-dehydrogenase 1 Inhibitor 4'-(6-methoxypyrid... 5 34
Integrin alpha-V and Integrin beta-1 Inhibitor SB-265123 Family 30 170
Adenosine receptor A1 and Adenosine receptor A3 Ligand 4-metho... 1 16
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 12 3
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 7 6
Metabotropic glutamate receptor 5 Ligand (3-ethoxy-pyridin-2-y... 3 12
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 5 1
Peptidyl-prolyl cis-trans isomerase A Inhibitor 3-[3-(3-benzyl... 3 34
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor 5-hexy... 4 5
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor 5-hexy... 2 3
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 2 3
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 17 49
5-hydroxytryptamine receptor 1A Ligand CP-293019 Family 9 24
Metabotropic glutamate receptor 5 Ligand 3-methoxy-n-(6-methyl... 3 15
Endothelin-1 receptor and Endothelin B receptor ligand (5S,6R,... 23 8
Mitogen-activated protein kinase 14 inhibitor N-(4-aminobutyl)... 1 28
Integrin beta-3 and Integrin alpha-V inhibitor (3S)-3-(1,3-ben... 6 5
Adenosine kinase inhibitor 5-[3-(4-methoxyphenyl)propyl]-6-[2-... 2 11
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 4
Dual specificity protein kinase CLK1 and Dual specificity prot... 2 14
Reverse transcriptase/RNaseH inhibitor AC1MHDM5 family 2 0
Dual specificity tyrosine-phosphorylation-regulated kinase 1A ... 3 20
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 3
Lethal factor and Dual specificity protein kinase CLK4 inhibit... 1 3
Prostaglandin D2 receptor ligand 1-[3-[2-methoxy-6-[2-(4-metho... 6 16
Tyrosine-protein kinase ABL1 and Proto-oncogene tyrosine-prote... 2 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 3
Integrin beta-3 and Integrin alpha-V inhibitor (3S)-3-(1,3-ben... 8 3
Corticotropin-releasing factor receptor 1 ligand 8-(2-chloro-4... 13 1
Melanin-concentrating hormone receptor 1 ligand 3-[6-[3-(dimet... 14 6
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 3 14
TRAF2 and NCK-interacting protein kinase inhibitor 4-methoxy-3... 4 1
Histone-arginine methyltransferase CARM1 inhibitor AGN-PC-00HE... 4 4
Aurora kinase B and Aurora kinase A inhibitor 2-fluoro-6-metho... 2 0
Cathepsin K and Cathepsin S inhibitor SureCN4135077 family 2 0
Adenosine receptor A1 and Adenosine receptor A2a ligand 2-amin... 4 3
Vascular endothelial growth factor receptor 2 ligand N-(4-chlo... 4 4
Dihydrofolate reductase inhibitor AC1LAPW3 family 3 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4A inhibitor AGN-... 1 3
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase inhibitor 1-... 1 3
Tyrosine-protein kinase Lck and Vascular endothelial growth fa... 1 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and Potassium ... 1 0
Beta-secretase 1 and Beta-secretase 2 inhibitor AGN-PC-076LAV ... 1 3


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00376021 CHEMBL349635 Bioactive SureCN7906655
CFAMM00376014 CHEMBL164199 Bioactive AGN-PC-0754UT
CFAMM00376020 CHEMBL166297 Bioactive SureCN7906652
CFAMM00376007 CHEMBL351187 Bioactive SureCN7905267
CFAMM00376019 CHEMBL164564 Bioactive SureCN7906644
CFAMM00376012 CHEMBL444865 Bioactive SureCN7906824
CFAMM00376005 CHEMBL162485 Bioactive SureCN7384099
CFAMM00376024 CHEMBL354931 Bioactive SureCN7899114
CFAMM00376004 CHEMBL165889 Bioactive SureCN7899072
CFAMM00376023 CHEMBL351007 Bioactive SureCN7374481
CFAMM00376003 CHEMBL423252 Bioactive N-[5-[1-[3,4-bis(difluoromethoxy)phenyl]-2-(1-oxidopyridin-1-ium-4-yl)ethyl]pyridin-2-yl]-2-phenylacetamide
CFAMM00376009 CHEMBL166245 Bioactive AGN-PC-0754TW
CFAMM00376022 CHEMBL166299 Bioactive SureCN7899088
CFAMM00376008 CHEMBL165687 Bioactive SureCN7899109

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26240 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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