CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM6950
Family Name Adenosine receptor A3 and Adenosine receptor A1 ligand (8R)-8-ethyl-4-methyl-2-phenyl-7,8-dihydro-1H-imidazo[2,1-f]purin-5-one family
No. of Seeds 4 No. of Other Members 0
Family Centroid CFAMM00181539 Functional Category Bioactive
Superfamily Adenosine receptor A3 and Beta-lactamase Binder Superfamily
Class Class 375

Cousin Family NamesSeedsMembers
Alpha-2 adrenergic receptor Ligand Dexmedetomidine Family 32 639
Toll-like receptor 7 Ligand Imiquimod Family 3 237
Amiloride-sensitive sodium channel subunit alpha Ligand Triamt... 8 98
Histamine H1 receptor Ligand Mizolastine Family 14 603
C-X-C chemokine receptor type 4 Ligand AMD-070 Family 12 800
Cyclin-dependent kinase 2 Inhibitor Seliciclib Family 29 292
Fibroblast growth factor receptor 2 and Fibroblast growth fact... 11 86
Dipeptidyl peptidase 4 Inhibitor Linagliptin Family 10 81
cAMP-specific 3',5'-cyclic phosphodiesterase 4D Inhibitor Arof... 3 196
Adenosine receptor A1 and Adenosine receptor A2a Ligand 8-phen... 12 213
Adenosine receptor A1 and Adenosine receptor A2b Ligand PSB-11... 34 26
Tryptase Inhibitor Babim Family 12 90
D(4) dopamine receptor Ligand L-745,870 Family 30 205
Herpes simplex virus type 1 thymidine kinase Inhibitor 9-(4-hy... 2 13
Beta-secretase 1 Inhibitor 6-[2-(1h-indol-6-yl)ethyl]pyridin-2... 10 43
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2,6-di... 13 14
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... 18 109
Epidermal growth factor receptor Ligand PD-158780 Family 98 89
Adenosine receptor A2a and Adenosine receptor A3 Ligand 5-buty... 3 18
Arachidonate 5-lipoxygenase Inhibitor 2,4,5-triarylimidazole A... 3 16
Adenosine receptor A3 Ligand 1-benzyl-1h-1,3,4b,9-tetraaza-flu... 19 165
Mitogen-activated protein kinase 3 and RAF proto-oncogene seri... 8 5
RAC-gamma serine/threonine-protein kinase and Rho-associated p... 16 46
Adenosine receptor A2b Ligand CVT-7124 Family 14 64
Histamine H4 receptor Ligand A-943931 Family 14 11
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Adenosine receptor A2a Ligand (e,e)-8-(4-phenylbutadien-1-yl)c... 11 43
Adenosine receptor A1 and Adenosine receptor A2a Ligand OSIP-3... 4 31
Sodium channel protein type 1 subunit alpha and Sodium channel... 10 14
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor SCH-577... 9 29
Prothrombin inhibitor SureCN5856722 family 3 16
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 9
Adenosine receptor A1 ligand SureCN10614388 family 5 1
Adenosine receptor A1 ligand 8-(2-amino-4-nitrophenyl)-1,3-dim... 1 0
Adenosine receptor A1 and Adenosine receptor A2b ligand 3-meth... 7 19
Adenosine receptor A2a and Adenosine receptor A1 ligand SureCN... 2 1
Histamine H4 receptor ligand SureCN602132 family 1 8
RAC-alpha serine/threonine-protein kinase and Proline-rich AKT... 2 4
Adenosine receptor A3 and Nuclear receptor ROR-gamma ligand (8... 1 0
Corticotropin-releasing factor receptor 1 ligand 9-(2-bromo-4-... 15 3
Corticotropin-releasing factor receptor 1 ligand SureCN6301726... 4 1
Adenosine receptor A2a and Adenosine receptor A2b ligand SureC... 2 2
Adenosine receptor A3 and Adenosine receptor A1 ligand (2Z)-2-... 5 3
Adenosine receptor A3 ligand (2Z)-2-(5-methoxy-2-methyl-1H-pyr... 8 4
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2206623 family 10 11
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 2 2
Cell division cycle 7-related protein kinase and Protein DBF4 ... 15 7
Vascular endothelial growth factor receptor 2 ligand (3Z)-6-fl... 4 3
Platelet-derived growth factor receptor beta and Vascular endo... 5 12
Cannabinoid receptor 2 ligand 8-(2-chlorophenyl)-9-cyclopropyl... 4 5
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2152412 family 8 0
Mitogen-activated protein kinase 14 inhibitor 6-[2-(2,6-difluo... 3 0
Urokinase plasminogen activator surface receptor ligand 3-(1H-... 4 0
Orexin receptor type 2 and Orexin receptor type 1 ligand (2R)-... 12 16
Adenosine receptor A1 and Adenosine receptor A2b ligand 1-meth... 6 4
Adenosine receptor A1 ligand 3-(4-Aminophenethyl)-8-(3-noradam... 1 0
Gonadotropin-releasing hormone receptor ligand 4-[[4-[2-(4-ter... 3 3
Platelet-derived growth factor receptor beta and Fibroblast gr... 10 0
LIM domain kinase 1 and LIM domain kinase 2 inhibitor (2S)-N'-... 9 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00376031 CHEMBL2181965 Bioactive 2-(4-bromophenyl)-4-propyl-7,8-dihydro-1H-imidazo[2,1-f]purin-5-one
CFAMM00376030 CHEMBL1800865 Bioactive (8R)-8-ethyl-4-methyl-2-(2,3,5-tritritiophenyl)-7,8-dihydro-1H-imidazo[2,1-f]purin-5-one

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27278 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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