CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM6961
Family Name D(3) dopamine receptor ligand N-[4-[4-(2,3-dichlorophenyl)piperazin-1-yl]-3-hydroxybutyl]-5-methoxy-1H-indole-2-carboxamide family
No. of Seeds 3 No. of Other Members 15
Family Centroid CFAMM00376151 Functional Category Bioactive with Natural Product
Superfamily Neuropeptide Y receptor type 1 and Substance-P receptor Binder Superfamily
Class Class 4064

Cousin Family NamesSeedsMembers
Melatonin receptor type 1A Ligand Melatonin Family 20 988
Sodium channel protein type 5 subunit alpha Ligand Dibucaine F... 2 136
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor indole... 28 2712
Cyclooxygenase Inhibitor Indomethacin Family 6 271
Phospholipase A2 Inhibitor Quinacrine Family 13 95
Arachidonate 5-lipoxygenase Inhibitor MK-591 Family 9 161
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 12 197
Nicotinic acetylcholine receptor alpha2 / alpha3 Ligand Ibogai... 3 21
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 37 265
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
von Willebrand factor Inhibitor Auryntricarboxylic Acid (ata) ... 12 81
Integrin beta-3 Inhibitor L-756568 Family 8 59
Vascular endothelial growth factor receptor 1 Ligand Lycogarub... 6 292
Platelet-derived growth factor receptor alpha and Platelet-der... 4 54
Platelet-derived growth factor receptor alpha and Platelet-der... 2 13
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
Prostaglandin E2 receptor EP1 subtype Ligand GSK-345931A Family 5 14
Adenosine receptor A1 and Adenosine receptor A2a Ligand SB-298... 53 320
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 24 64
Arachidonate 5-lipoxygenase Inhibitor TZI-41127 Family 7 34
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 3 16
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 7 44
Glycogen synthase kinase-3 beta and Protein kinase C alpha typ... 2 30
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 7 11
Vasopressin V1a receptor and Vasopressin V2 receptor ligand (3... 4 41
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 14 48
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 8 32
Histamine H3 receptor and Cytochrome P450 2D6 ligand AGN-PC-00... 18 32
Histamine H3 receptor ligand AGN-PC-00BG7Z family 11 49
Histamine H3 receptor ligand (4S)-7-bromo-4-methyl-8-(1-propan... 2 0
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 10 50
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 4 6
Glutamate receptor ionotropic, NMDA 2D and Glutamate receptor ... 2 21
Cellular tumor antigen p53 inhibitor CHEMBL1395699 family 1 30
Poly [ADP-ribose] polymerase 1 inhibitor SureCN5002485 family 2 11
Translocator protein inhibitor N-(4-methoxyphenyl)-N,3-dimethy... 2 2
Glutamate receptor ionotropic, NMDA 1 ligand (3S)-3-[2-[4-(ami... 1 1
Matrix metalloproteinase-9 and Interstitial collagenase inhibi... 2 3
Cannabinoid receptor 1 ligand 5-cyano-N-(3-hydroxy-2,2-dimethy... 17 4
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 5
Histone deacetylase 3 and Histone deacetylase 9 inhibitor (3S,... 1 16
Prostaglandin D2 receptor and Prostacyclin receptor ligand 2-[... 15 2
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 5 2
D(2) dopamine receptor and Alpha-1B adrenergic receptor ligand... 3 4
NS5B protein inhibitor AC1O5AET family 3 1
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 9 inhibitor 3-... 4 8
Glucagon receptor ligand 3-[[4-[(2S)-2-[5-(trifluoromethoxy)-1... 1 2
Translocator protein inhibitor (4S)-N,N-diethyl-9-(2-fluoranyl... 9 10
Histone deacetylase 6 and Histone deacetylase 1 inhibitor N-hy... 3 2
Histamine H3 receptor ligand 2-[4-(1-methylpyrrole-2-carbonyl)... 3 4
Thyroid hormone receptor beta and Thyroid hormone receptor alp... 1 1
Substance-P receptor ligand 1-[4-(2-methoxyphenyl)piperazin-1-... 11 12
Substance-P receptor ligand AGN-PC-01VLKE family 9 11
Acetylcholinesterase and Cholinesterase inhibitor N-[5-[(6-chl... 4 2
Cannabinoid receptor 1 ligand AGN-PC-0766FR family 4 3
3-oxo-5-alpha-steroid 4-dehydrogenase 2 inhibitor 4-(benzyloxy... 1 10
Peroxisome proliferator-activated receptor delta and Peroxisom... 7 5
Beta-2 adrenergic receptor ligand SureCN4598646 family 7 7
Peroxisome proliferator-activated receptor delta and Peroxisom... 2 1
Seprase and Prolyl endopeptidase inhibitor N-[2-[(2S)-2-cyanop... 1 3
Estrogen receptor and Estrogen receptor beta ligand N-[(2R)-4-... 7 11
Proto-oncogene tyrosine-protein kinase receptor Ret and Vascul... 5 14
Wee1-like protein kinase and Serine/threonine-protein kinase C... 8 0
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 1 1
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 1 0
Histone deacetylase 3 and Histone deacetylase 9 inhibitor AGN-... 4 20
Mu-type opioid receptor ligand MITRAGYNINE family 2 8
Cathepsin K inhibitor N-[(2S)-4-methyl-1-[2-[4-(2-methylpropox... 4 0
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 1 1
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 3 9
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 0
Thyroid hormone receptor beta and Thyroid hormone receptor alp... 1 1
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor CHEMBL4... 6 2
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 5 0
P2Y purinoceptor 12 inhibitor (4S)-4-[[4-[(1-acetylpiperidin-4... 58 15
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 2 3
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand 18000... 1 1
Signal transducer and activator of transcription 1-alpha/beta ... 1 36
Gamma-aminobutyric acid receptor subunit pi and Gamma-aminobut... 2 10
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 2 0
Peroxisome proliferator-activated receptor gamma ligand AGN-PC... 6 5
Potassium voltage-gated channel subfamily A member 5 ligand AG... 1 0
Neuropeptide Y receptor type 1 ligand [1-(4-chlorophenoxy)-9-[... 5 7
Potassium-transporting ATPase alpha chain 1 and Potassium-tran... 1 3
Indoles Metabolite Mukeic acid Family 1 1
Amino Acids and Derivatives Metabolite Flazine Family 3 2
NP Ethyl 7-amino-5h-[1,3]dioxolo[4,5-f]indole-6-carboxylate Fa... 2 0
1-[4-methoxy-3-[(3-methyl-4-nitrophenoxy)methyl]phenyl]-2,3,4,... 6 0
1-(7-methyl-4-oxochromen-3-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,... 8 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00376151 CHEMBL1627314 Bioactive N-[4-[4-(2,3-dichlorophenyl)piperazin-1-yl]-3-hydroxybutyl]-5-methoxy-1H-indole-2-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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