CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM6962
Family Name D(3) dopamine receptor and D(4) dopamine receptor ligand N-[3-hydroxy-4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl]-5-iodo-1-benzofuran-2-carboxamide family
No. of Seeds 4 No. of Other Members 2
Family Centroid CFAMM00376158 Functional Category Bioactive
Superfamily Sodium channel protein type 10 subunit alpha Ligand A-803467 Superfamily
Class Class 1685

Cousin Family NamesSeedsMembers
Sodium channel protein type 5 subunit alpha Ligand Encainide F... 4 248
Mucosal addressin cell adhesion molecule 1 Inhibitor PF-005476... 64 96
5-hydroxytryptamine receptor 1A Ligand (s)-way 100135 Family 94 975
Alpha-2C adrenergic receptor Ligand ARC239 Family 15 23
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Cilost... 6 202
5-hydroxytryptamine receptor 1A Ligand NAN-190 Family 14 28
Sodium channel protein type 10 subunit alpha Ligand A-803467 F... 2 81
Histamine H3 receptor Ligand A-317920 Family 9 240
5-hydroxytryptamine receptor 1A and Alpha-1A adrenergic recept... 18 12
cAMP-specific 3',5'-cyclic phosphodiesterase 4A Inhibitor 4-(2... 4 31
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 6 23
Substance-K receptor Ligand MEN-14933 Family 13 154
Alpha-1A adrenergic receptor Ligand Upidosin Family 8 46
Alpha-1A adrenergic receptor Ligand Naftopidil Family 15 119
Granulocyte colony-stimulating factor receptor Ligand N-(2-mor... 1 24
Leukotriene A-4 hydrolase Inhibitor N5-[4-(2-oxo-3-phenylpropo... 1 61
Leukotriene A-4 hydrolase Inhibitor N5-[4-(4-(3-furyl)phenoxy)... 7 71
Macrophage migration inhibitory factor Inhibitor Benzofuran-2-... 5 67
Sodium channel protein type 10 subunit alpha and Sodium channe... 2 13
Urotensin-2 receptor Ligand JNJ-28318706 Family 4 227
Galanin receptor type 1 and Galanin receptor type 2 Ligand Gal... 55 132
Reverse transcriptase Inhibitor 10-propyl-10h-dibenzo[b,f][1,4... 9 60
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 8 39
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 2 17
Substance-K receptor ligand 5-chloro-N-[1-[[(2S)-5-[4-(oxan-4-... 2 4
D(2) dopamine receptor ligand 7-[4-[4-(2-ethoxyphenyl)piperazi... 12 14
Beta-secretase 1 inhibitor SureCN3599637 family 1 0
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 14 12
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 2 0
Sigma non-opioid intracellular receptor 1 and 5-hydroxytryptam... 20 9
Collagenase 3 inhibitor N-[[3-[5-[[(1R)-1-cyclohexyl-2-(methyl... 4 2
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 11 4
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 49 8
D(3) dopamine receptor and D(1A) dopamine receptor ligand N-[(... 6 14
Sodium channel protein type 10 subunit alpha ligand AGN-PC-09M... 1 7
D(3) dopamine receptor and D(2) dopamine receptor ligand (E)-N... 2 2
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 1 35
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 4 4
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 4 1
Cellular tumor antigen p53 and Microtubule-associated protein ... 1 6
D(3) dopamine receptor and D(4) dopamine receptor ligand N-[4-... 6 16
Prelamin-A/C and Survival motor neuron protein inhibitor CHEMB... 1 7
C5a anaphylatoxin chemotactic receptor 1 ligand N-[(4-dimethyl... 1 4
Prostaglandin E2 receptor EP4 subtype ligand SureCN5653729 family 3 2
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 5 2
Androgen receptor ligand (2R)-2-ethyl-1-(2,2,2-trifluoroethyl)... 32 6
Prostaglandin D2 receptor and Prostacyclin receptor ligand 2-[... 15 5
Collagenase 3 and Matrilysin inhibitor N-({4'-[(1-BENZOFURAN-2... 24 45
MAP kinase-activated protein kinase 2 inhibitor 5-(4-cyanophen... 3 8
Cathepsin K and Cathepsin L1 inhibitor 4-ethyl-N-[(2S)-1-[2-(4... 7 10
Cathepsin S and Cathepsin K inhibitor arylaminoethyl amide, 7 ... 2 0
Kappa-type opioid receptor and Cytochrome P450 2D6 ligand Sure... 4 3
Translocator protein inhibitor N-[(2,5-dimethoxyphenyl)methyl]... 1 0
Histamine H3 receptor ligand SureCN5221194 family 1 8
Histamine H3 receptor ligand SureCN5218144 family 4 6
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 9 3
Potassium voltage-gated channel subfamily H member 2 and Melan... 5 4
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 6 11
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[4-... 5 8
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 10
Alpha-2C adrenergic receptor and Alpha-2A adrenergic receptor ... 4 13
Macrophage colony-stimulating factor 1 receptor ligand 5-cyano... 5 6
5-hydroxytryptamine receptor 1A ligand SureCN10513645 family 9 1
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 2 11
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 2 0
Glucagon receptor and Adenylate cyclase type 1 ligand AGN-PC-0... 2 3
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 5 2
Oxytocin receptor and Vasopressin V1a receptor ligand N-[[5-[4... 1 0
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 1 0
Mu-type opioid receptor ligand AGN-PC-00NCMO family 3 1
Muscarinic acetylcholine receptor M2 and Muscarinic acetylchol... 1 1
Glucagon receptor and Adenylate cyclase type 1 ligand AGN-PC-0... 3 1
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 1 1
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 1 0
Mitogen-activated protein kinase 14 inhibitor AGN-PC-00A4QT fa... 2 0
Mitogen-activated protein kinase 14 inhibitor ITX 5061 free ba... 2 3
Mitogen-activated protein kinase 14 inhibitor AGN-PC-04UTCQ fa... 2 1
Sphingosine 1-phosphate receptor 4 ligand AGN-PC-079GSR family 11 7
Huntingtin and Ras-related protein Rab-9A inhibitor CHEMBL1971... 1 1
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 2 0
Mitogen-activated protein kinase 14 inhibitor SureCN1600485 fa... 1 1
Cyclin-dependent kinase 4 inhibitor SureCN3563106 family 1 1
Nuclear receptor ROR-gamma and Niemann-Pick C1 protein ligand ... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00376158 CHEMBL1627319 Bioactive N-[3-hydroxy-4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl]-5-iodo-1-benzofuran-2-carboxamide
CFAMM00376159 CHEMBL1627317 Bioactive N-[3-hydroxy-4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl]-1-benzofuran-2-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26843 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543