CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM6969
Family Name Sigma non-opioid intracellular receptor 1 ligand 1-[2-(3,4-dichlorophenyl)ethyl]-4-(3-phenylpropyl)piperazine family
No. of Seeds 8 No. of Other Members 4
Family Centroid CFAMM00376187 Functional Category Bioactive
Superfamily Dopamine reuptake and Noradrenergic re-uptake Inhibitor Dov 21947 Superfamily
Class Class 48

Cousin Family NamesSeedsMembers
Serotonin re-uptake inhibitor tetralin derivative Sertraline f... 12 118
Noradrenergic re-uptake and Serotonin re-uptake Inhibitor Sibu... 7 127
Histamine H1 receptor ligand piperazine derivative Cyclizine F... 16 140
Nuclear receptor subfamily 1 group I member 3 ligand piperazin... 3 82
Neuromedin-K receptor Ligand Osanetant Family 38 192
Dopamine reuptake and Noradrenergic re-uptake Inhibitor Dov 21... 16 89
5-hydroxytryptamine receptor 2C Ligand Lorcaserin Family 8 38
Tumor necrosis factor Inhibitor Talactoferrin Alfa Family 26 131
Zicronapine family 43 62
3-oxo-5-alpha-steroid 4-dehydrogenase 1 Inhibitor 5-(4-chloro-... 10 52
3-oxo-5-alpha-steroid 4-dehydrogenase 1 Inhibitor 5-(4-chloro-... 3 7
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 6 7
Dipeptidyl peptidase 4 Inhibitor 2-(2-chlorophenyl)-2-morpholi... 2 34
Sodium-dependent dopamine transporter and Sodium-dependent ser... 5 1
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-n-... 5 6
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-3'... 14 11
Sigma non-opioid intracellular receptor 1 ligand NCI60_038428 ... 5 9
Sigma non-opioid intracellular receptor 1 and D(2) dopamine re... 18 4
Pyruvate kinase PKM and Huntingtin inhibitor CHEMBL1455935 family 1 3
Substance-P receptor ligand 4-[1-[2-[1-(cyclopropylmethyl)-3-(... 10 6
Substance-K receptor ligand (5S)-1-(2-cyclopropylethyl)-5-(3,4... 10 0
Sodium-dependent serotonin transporter and Sodium-dependent do... 5 6
Sodium-dependent dopamine transporter and Sodium-dependent nor... 2 2
Sodium-dependent dopamine transporter and Sodium-dependent nor... 2 0
Transporter and Sodium-dependent dopamine transporter inhibito... 3 0
Transporter and Sodium-dependent serotonin transporter inhibit... 4 8
Substance-K receptor ligand SureCN3083325 family 4 0
Sodium-dependent serotonin transporter and Sodium-dependent no... 3 4
Sodium-dependent serotonin transporter and Sodium-dependent no... 3 3
Sodium-dependent noradrenaline transporter and Sodium-dependen... 2 12
Sodium-dependent dopamine transporter and Sodium-dependent nor... 3 1
D(1A) dopamine receptor and D(3) dopamine receptor ligand 2-[4... 1 0
Sodium-dependent serotonin transporter and Sodium-dependent no... 2 0
D(1A) dopamine receptor and D(2) dopamine receptor ligand A314... 3 1
Sigma non-opioid intracellular receptor 1 ligand NCI60_039912 ... 2 0
D(2) dopamine receptor and D(1A) dopamine receptor ligand AGN-... 2 1
Sodium-dependent dopamine transporter and Muscarinic acetylcho... 2 6
Sodium-dependent dopamine transporter and Sodium-dependent nor... 1 0
Muscarinic acetylcholine receptor M2 and Muscarinic receptor 3... 1 0
Glucose-6-phosphatase inhibitor SureCN8498194 family 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00376187 CHEMBL343654 Bioactive 1-[2-(3,4-dichlorophenyl)ethyl]-4-(3-phenylpropyl)piperazine
CFAMM00376193 CHEMBL309062 Bioactive 2-[2-(3,4-dichlorophenyl)ethyl]-1,3,4,6,7,8,9,9a-octahydropyrido[1,2-a]pyrazine
CFAMM00376186 CHEMBL420557 Bioactive 1-[2-(3,4-dichlorophenyl)ethyl]-4-(3-iodopropyl)piperazine
CFAMM00376192 CHEMBL312766 Bioactive 1-[2-(3,4-Dichlorophenyl)ethyl]-4-(5-fluoropentyl)piperazine
CFAMM00376185 CHEMBL308284 Bioactive AGN-PC-074IRY
CFAMM00376190 CHEMBL70540 Bioactive AC1LC4K4
CFAMM00376183 CHEMBL162807 Bioactive STK116241

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

48713 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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