CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM6987
Family Name C-C chemokine receptor type 1 ligand N-[(2S,3S,5R)-5-carbamoyl-3-hydroxy-8-methyl-1-phenylnonan-2-yl]quinoxaline-2-carboxamide family
No. of Seeds 10 No. of Other Members 4
Family Centroid CFAMM00376262 Functional Category Bioactive
Superfamily HIV-1 protease Inhibitor Atazanavir Superfamily
Class Class 137

Cousin Family NamesSeedsMembers
HIV protease Inhibitor Indinavir Family 36 211
HIV protease Inhibitor Saquinavir Family 64 428
Somatostatin receptor type 2 ligand octapeptide Octreotide Family 27 172
HIV-1 protease Inhibitor Atazanavir Family 16 58
26S proteasome Inhibitor Bortezomib Family 7 65
Coagulation factor X Inhibitor Otamixaban Family 9 21
CP-18770 family 6 27
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
Lethal factor Inhibitor GM6001 Family 50 435
Integrin beta-3 Inhibitor Elarofiban Family 28 45
Renin Inhibitor Sul-pro-phe-n-mehis-lva-ile-amp Family 47 54
Cholecystokinin receptor type A Ligand VL-0395 Family 12 117
Delta-type opioid receptor Ligand H-poa-ser-gly-phe-leu-thr-oh... 5 12
Cannabinoid receptor 1 Ligand N-phenyl-5,6-dip-tolylpyrazine-2... 11 26
Bifunctional epoxide hydrolase 2 Inhibitor N-(3,3-diphenyl-pro... 6 14
Endothelin B receptor Ligand IRL-2500 Family 34 87
Vasopressin V1a receptor and Vasopressin V1b receptor Ligand D... 10 19
Metabotropic glutamate receptor 1 Ligand N-(2-phenylpropyl)qui... 3 1
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Renin inhibitor (2S,4S,5S)-6-cyclohexyl-4-hydroxy-5-[[(2S)-2-[... 3 0
Pol polyprotein inhibitor AC1LAD48 family 19 5
Pol polyprotein inhibitor pyridin-2-ylmethyl N-[(2R)-1-[[(2S,3... 15 8
Cholecystokinin receptor type A ligand A-65186 family 2 6
Plasmepsin-1 and Plasmepsin-2 inhibitor Statine-like inhibitor... 13 5
Pol polyprotein inhibitor N-[(2S)-1-[[(2S,3R,4S,5S)-3,4-dihydr... 2 0
Pol polyprotein inhibitor N-[3-[[(4R,5R,6R)-4-benzyl-5-hydroxy... 1 0
Pol polyprotein inhibitor Carbamic acid, ((2-hydroxy-1,4-bis(p... 21 1
Renin inhibitor [(2S,4S,5S,7R)-4-amino-8-(butylamino)-5-hydrox... 3 1
Pol polyprotein and Protease inhibitor Palinavir family 1 0
Peptide deformylase inhibitor (2R)-N-[(2S)-3,3-dimethyl-1-oxo-... 2 1
Pol polyprotein and Cathepsin D inhibitor N-[(1S)-1-[(2R,3S)-3... 2 1
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 6 4
Pol polyprotein inhibitor (2S,4S,5S)-5-acetamido-6-cyclohexyl-... 3 3
Substance-K receptor ligand N-[1-[[(2R)-5-[4-(oxan-4-ylmethyl)... 2 0
Interstitial collagenase and Matrilysin inhibitor (2S,3R)-N,2-... 3 1
Renin inhibitor (3R)-4-[[(2S,5S)-1-cyclohexyl-3-hydroxy-6-meth... 3 4
Pol polyprotein inhibitor (2R,3R,4R,5S)-5-[[(2S)-2-[5-[(4R,6aS... 1 0
Integrin beta-3 and Integrin alpha-V inhibitor AGN-PC-075FXA f... 1 0
Orexin receptor type 1 and Orexin receptor type 2 ligand N-[[(... 1 0
Pol polyprotein inhibitor AC1LAHQ9 family 8 15
Prothrombin and Tissue-type plasminogen activator inhibitor 2-... 4 5
Renin inhibitor tert-butyl N-[1-[[1-[[(2S,3S)-1-cyclohexyl-3-h... 1 0
Cannabinoid receptor 1 ligand N-(cyclobutylmethyl)-3-[[4-(meth... 1 1
Cannabinoid receptor 1 and Cytochrome P450 3A4 ligand N-(oxan-... 2 0
Renin inhibitor (2S,4S,5S)-5-amino-6-[4-(2-chlorophenyl)-2,2-d... 3 0
Metabotropic glutamate receptor 5 ligand AGN-PC-09SALK family 2 15
Renin inhibitor tert-butyl N-[1-[[1-[[1-cyclohexyl-4,4-difluor... 5 0
Pol polyprotein inhibitor AC1LALGZ family 2 14
Stromelysin-1 and 72 kDa type IV collagenase inhibitor (2S,4R)... 2 2
Pol polyprotein inhibitor 183854-15-1 family 3 0
Renin and Cathepsin D inhibitor (4S)-5-cyclohexyl-2,2-difluoro... 4 1
Substance-P receptor ligand (4R)-N-[(2R)-1-[benzyl(methyl)amin... 8 5
Renin inhibitor tert-butyl N-[1-[[1-[[(3R,4S)-1-cyclohexyl-3,4... 2 2
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[(1-benz... 2 1
P2Y purinoceptor 12 inhibitor (4S)-4-[[4-[4-[3-(dimethylamino)... 106 49
Cannabinoid receptor 1 ligand N-(1-hydroxy-2,3-dihydro-1H-inde... 1 0
Pol polyprotein inhibitor AC1LA6OV family 1 2
C-C chemokine receptor type 1 ligand 5-bromo-N-[(2S,3S,5R)-3-h... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00376266 CHEMBL68145 Bioactive N-[(2S,3S)-6-amino-5-cyclohexyl-3-hydroxy-6-oxo-1-phenylhexan-2-yl]quinoxaline-2-carboxamide
CFAMM00376271 CHEMBL66159 Bioactive N-[(2S,3S)-8-fluoro-5-(hydrazinecarbonyl)-3-hydroxy-8-methyl-1-phenylnonan-2-yl]quinoxaline-2-carboxamide
CFAMM00376264 CHEMBL68366 Bioactive N-[(2S,3S,5R)-5-carbamoyl-8-fluoro-3-hydroxy-8-methyl-1-phenylnonan-2-yl]quinoxaline-2-carboxamide
CFAMM00376270 CHEMBL71334 Bioactive AC1NUJRT
CFAMM00376263 CHEMBL303673 Bioactive N-[(2S,3S)-5-(4,4-difluorocyclohexyl)-3-hydroxy-6-(hydroxyamino)-6-oxo-1-phenylhexan-2-yl]quinoxaline-2-carboxamide
CFAMM00376262 CHEMBL304358 Bioactive N-[(2S,3S,5R)-5-carbamoyl-3-hydroxy-8-methyl-1-phenylnonan-2-yl]quinoxaline-2-carboxamide
CFAMM00376268 CHEMBL69375 Bioactive N-[(2S,3S,5S)-6-amino-5-cyclohexyl-3-hydroxy-6-oxo-1-phenylhexan-2-yl]quinoxaline-2-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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