CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM6996
Family Name Metabotropic glutamate receptor 2 and Metabotropic glutamate receptor 3 ligand RO4491533 family
No. of Seeds 5 No. of Other Members 3
Family Centroid CFAMM00376416 Functional Category Bioactive
Superfamily Metabotropic glutamate receptor 2 and Kinesin-like protein KIF11 Binder Superfamily
Class Class 3380

Cousin Family NamesSeedsMembers
Sodium channel protein type 5 subunit alpha Ligand Disopyramid... 4 352
Prothrombin Inhibitor Ximelegatran Family 8 157
Transient receptor potential cation channel subfamily V member... 15 158
Neuromedin-K receptor Ligand SB222200 Family 17 235
Mitogen-activated protein kinase 14 Inhibitor Losmapimod Family 5 154
Glutamate receptor AMPA subtype Ligand CX-516 Family 9 24
Gamma-aminobutyric acid receptor Ligand E-2007 Family 7 118
D(3) dopamine receptor Ligand SB-277011 Family 13 178
Substance-P receptor Ligand TAK-637 Family 18 63
JAK Inhibitor Momelotinib Family 33 83
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
XL-888 family 16 85
cGMP-dependent 3',5'-cyclic phosphodiesterase Inhibitor CP-461... 4 34
Carbonic anhydrase 2 Inhibitor N-[2-(1h-indol-5-yl)-butyl]-4-s... 12 70
cAMP-specific 3',5'-cyclic phosphodiesterase 4A Inhibitor 8-(3... 4 19
cAMP-specific 3',5'-cyclic phosphodiesterase 4A Inhibitor 8-(3... 4 22
cGMP-inhibited 3',5'-cyclic phosphodiesterase A and Cytochrome... 9 40
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor N-(4... 4 21
Poly [ADP-ribose] polymerase 1 Inhibitor 1,7,8,9-tetrahydro-1,... 19 64
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-(3-cyano-... 2 4
Transient receptor potential cation channel subfamily V member... 6 23
D(4) dopamine receptor Ligand ABT-670 Family 4 14
Cannabinoid receptor 1 Ligand N-phenyl-5,6-dip-tolylpyrazine-2... 11 26
C-C chemokine receptor type 5 Ligand GT-1282 Family 21 14
Poly [ADP-ribose] polymerase 1 Inhibitor 3-ethenylquinoline-8-... 8 4
Peroxisome proliferator-activated receptor gamma Ligand 2-chlo... 5 19
Bifunctional epoxide hydrolase 2 Inhibitor N-(3,3-diphenyl-pro... 6 14
Mitogen-activated protein kinase 14 Inhibitor N-(4-fluorobenzy... 19 32
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 2 4
Glutamate receptor 1 Ligand Piriqualone Family 8 67
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 3 27
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Acetylcholinesterase and Cholinesterase Inhibitor 7-oxo-7h-dib... 2 3
Histone deacetylase 3 and Histone deacetylase 6 inhibitor Tria... 20 37
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK1 ... 2 4
Gonadotropin-releasing hormone receptor ligand 1-(3-azabicyclo... 6 2
Survival motor neuron protein and Beta-lactamase inhibitor CHE... 1 0
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-09M6D1 family 2 5
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 13 1
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 1 1
Metabotropic glutamate receptor 2 and Metabotropic glutamate r... 3 3
Metabotropic glutamate receptor 2 ligand AGN-PC-09QJ9P family 2 7
Metabotropic glutamate receptor 2 ligand AGN-PC-09QHIM family 2 0
Metabotropic glutamate receptor 2 ligand AGN-PC-00A1HD family 2 0
Gonadotropin-releasing hormone receptor ligand 1-(3-azabicyclo... 9 10
Dipeptidyl peptidase 4 inhibitor AGN-PC-09QKOM family 5 8
Substance-K receptor ligand N-[1-[[(2R)-5-[4-(oxan-4-ylmethyl)... 2 0
Gonadotropin-releasing hormone receptor and Cytochrome P450 3A... 5 1
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 18 3
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 3 2
Renin inhibitor [2-[(3-fluoro-2-methylphenyl)methyl]-6-methyl-... 2 1
Substance-P receptor and Neuromedin-K receptor ligand 2-[3,5-b... 7 0
Mast/stem cell growth factor receptor Kit and Mitogen-activate... 4 2
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 3 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4B and cAMP-speci... 5 5
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 3 1
Substance-P receptor ligand 2-[3,5-bis(trifluoromethyl)phenyl]... 3 1
Egl nine homolog 1 inhibitor 1'-[(3-methylpyridin-2-yl)methyl]... 6 4
Substance-P receptor and Neuromedin-K receptor ligand 2-[3,5-b... 6 0
Substance-P receptor ligand Netupitant family 5 2
cAMP-specific 3',5'-cyclic phosphodiesterase 4B and cAMP-speci... 2 3
Probable G-protein coupled receptor 142 ligand (2S)-N-(2-oxo-5... 2 1
Gonadotropin-releasing hormone receptor ligand 1-adamantyl-[2-... 3 1
Metabotropic glutamate receptor 2 ligand 8-(2,5-difluorophenyl... 6 2
Metabotropic glutamate receptor 2 ligand 8-[2-(4-fluorophenyl)... 2 3
Gonadotropin-releasing hormone receptor ligand 1-[2-(3,5-dimet... 3 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 2
Calcitonin gene-related peptide type 1 receptor ligand N-[(2R)... 1 0
Gonadotropin-releasing hormone receptor ligand 1-[2-(3,5-dimet... 2 0
Cytochrome P450 2C9 inhibitor AGN-PC-04XDND family 1 3
Macrophage colony-stimulating factor 1 receptor ligand AGN-PC-... 3 0
Mast/stem cell growth factor receptor Kit and Tyrosine-protein... 4 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00376410 CHEMBL1629860 Bioactive AGN-PC-03NWY7
CFAMM00376416 CHEMBL1629855 Bioactive RO4491533
CFAMM00376415 CHEMBL1629856 Bioactive SureCN5557475
CFAMM00376414 CHEMBL1629857 Bioactive AGN-PC-03NWZ5
CFAMM00376411 CHEMBL1631867 Bioactive AGN-PC-09QMHS

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27525 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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