CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM7008
Family Name Tyrosine-protein kinase JAK3 inhibitor N-methyl-N-[(1S,5S)-2-methyl-5-prop-1-en-2-ylcyclohexyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine family
No. of Seeds 2 No. of Other Members 12
Family Centroid CFAMM00376508 Functional Category Bioactive
Superfamily Tyrosine-protein kinase JAK3 Binder Superfamily
Class Class 802

Cousin Family NamesSeedsMembers
Tyrosine-protein kinase JAK3 Inhibitor Tofacitinib Family 3 24
C-X-C chemokine receptor type 4 Ligand AMD-070 Family 12 800
Fibroblast growth factor receptor 2 and Fibroblast growth fact... 11 86
Tyrosine-protein kinase JAK2 Inhibitor INCB18424 Family 3 130
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
Adenosine receptor A1 Ligand SLV320 Family 6 79
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
RAC-gamma serine/threonine-protein kinase Inhibitor AZD5363 Fa... 35 69
D(4) dopamine receptor Ligand L-745,870 Family 30 205
Corticotropin-releasing factor receptor 1 Ligand R121919 Family 26 84
Beta-secretase 1 Inhibitor 6-[2-(1h-indol-6-yl)ethyl]pyridin-2... 10 43
Beta-secretase 1 Inhibitor N~3~-(3-pyridin-3-ylbenzyl)pyridine... 31 66
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... 18 109
Epidermal growth factor receptor Ligand PD-158780 Family 98 89
Scytalone dehydratase Inhibitor Isoquinolin-1-yl-(3-phenyl-pro... 4 9
RAC-gamma serine/threonine-protein kinase and Rho-associated p... 16 46
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Glycogen synthase kinase-3 beta Inhibitor CHIR-98023 Family 5 6
Proto-oncogene tyrosine-protein kinase Src Inhibitor CGP-62464... 3 10
Sodium channel protein type 1 subunit alpha and Sodium channel... 10 14
Acetylcholinesterase Inhibitor N-benzyl-2-morpholinopyrimidin-... 6 16
Prothrombin inhibitor SureCN5856722 family 3 16
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 10 3
RAC-alpha serine/threonine-protein kinase inhibitor AGN-PC-07Y... 1 3
RAC-alpha serine/threonine-protein kinase and Proline-rich AKT... 2 4
Cell division cycle 7-related protein kinase and Protein DBF4 ... 15 7
Protein kinase C theta type and Leucine-rich repeat serine/thr... 1 1
Aurora kinase A and Cyclin-dependent kinase 4 inhibitor 7-cycl... 1 0
Tyrosine-protein kinase JAK1 and Aurora kinase A inhibitor CHE... 2 0
Fatty-acid amide hydrolase 1 inhibitor 4-(3-phenyl-1,2,4-thiad... 2 1
LIM domain kinase 2 inhibitor (2S)-N-cyano-N'-(3-cyanophenyl)-... 4 0
D(4) dopamine receptor and D(3) dopamine receptor ligand SureC... 1 0
Nociceptin receptor and Mu-type opioid receptor ligand SureCN5... 1 0
LIM domain kinase 1 and LIM domain kinase 2 inhibitor (2S)-N'-... 9 0
Tyrosine-protein kinase JAK3 inhibitor N,N-diethyl-2-[(2R)-2-[... 3 0
Tyrosine-protein kinase JAK3 and Tyrosine-protein kinase JAK2 ... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00376510 CHEMBL1630782 Bioactive N-methyl-N-[(1S,2R,5S)-2-methyl-5-prop-1-en-2-ylcyclohexyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine
CFAMM00376508 CHEMBL1630781 Bioactive N-methyl-N-[(1S,5S)-2-methyl-5-prop-1-en-2-ylcyclohexyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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