CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM7028
Family Name Histone deacetylase 6 and Histone deacetylase 1 inhibitor AGN-PC-04XTHK family
No. of Seeds 6 No. of Other Members 11
Family Centroid CFAMM00376585 Functional Category Bioactive
Superfamily Beta-secretase 1 and Histone deacetylase 6 Binder Superfamily
Class Class 833

Cousin Family NamesSeedsMembers
Beta-1 adrenergic receptor Ligand Practolol Family 2 82
D(2) dopamine receptor Ligand Pardoprunox Family 4 81
Transforming growth factor-beta Inhibitor ACE-011 Family 1 13
Dihydroorotate dehydrogenase and Interleukin-17A Inhibitor Vid... 4 74
5-hydroxytryptamine receptor 1A Ligand (s)-way 100135 Family 94 975
Leukotriene A-4 hydrolase Inhibitor N5-[4-(phenylmethoxy)pheny... 7 49
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 6 23
Cannabinoid receptor 1 Ligand N-(4-methoxyphenyl)oleamide Family 4 23
Histone deacetylase 1 Inhibitor 7-(4-(dimethylamino)phenoxy)-n... 2 1
Histone deacetylase 2 Inhibitor 2-(benzyloxy)-n7-hydroxy-n1-ph... 1 3
Leukotriene A-4 hydrolase Inhibitor N5-[4-(2-oxo-3-phenylpropo... 1 61
5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine ... 8 41
Proto-oncogene tyrosine-protein kinase receptor Ret Ligand (z)... 1 60
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 21 13
Reverse transcriptase Inhibitor 10-propyl-10h-dibenzo[b,f][1,4... 9 60
Thyroid hormone receptor beta and Thyroid hormone receptor alp... 11 26
Androgen receptor ligand AGN-PC-00BRQF family 2 2
Matrix metalloproteinase-9 and 72 kDa type IV collagenase inhi... 4 2
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 1 0
Histone deacetylase 8 and Histone deacetylase 6 inhibitor (3S)... 4 16
Acyl-CoA:cholesterol acyltransferase inhibitor SureCN8115658 f... 1 3
Cathepsin K inhibitor N-[2-(4-methoxyanilino)ethyl]-4-methyl-2... 1 1
N-(4-acetamidophenyl)-2-(2,2-dimethyl-3,4-dihydrochromen-6-yl)... 1 0


External ID

Functional Category

Molecule Name

CFAMM00376581 CHEMBL1631917 Bioactive CHEMBL1631917
CFAMM00376585 CHEMBL1631916 Bioactive AGN-PC-04XTHK
CFAMM00376578 CHEMBL1631912 Bioactive N-hydroxy-6-(3-oxo-5,13-dioxa-2-azabicyclo[12.4.0]octadeca-1(18),14,16-trien-4-yl)hexanamide
CFAMM00376584 CHEMBL1631914 Bioactive CHEMBL1631914
CFAMM00376577 CHEMBL1631913 Bioactive CHEMBL1631913
CFAMM00376576 CHEMBL1631918 Bioactive CHEMBL1631918

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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