CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM7034
Family Name RAC-alpha serine/threonine-protein kinase inhibitor 2-[(4-chlorophenyl)methyl]-1-[4-[(5S)-5-methyl-5,7-dihydrothieno[3,4-d]pyrimidin-4-yl]piperazin-1-yl]-3-(propan-2-ylamino)propan-1-one family
No. of Seeds 11 No. of Other Members 2
Family Centroid CFAMM00376643 Functional Category Bioactive
Superfamily Mitogen-activated protein kinase 9 and Mitogen-activated protein kinase 8 Binder Superfamily
Class Class 4519

Cousin Family NamesSeedsMembers
Cannabinoid receptor 1 Ligand CP-945598 Family 18 173
Protein kinase C alpha type and Protein kinase C beta type Inh... 16 86
RAC-gamma serine/threonine-protein kinase Inhibitor GDC-0068 F... 20 29
RAC-gamma serine/threonine-protein kinase Inhibitor AZD5363 Fa... 35 69
Kappa-type opioid receptor Ligand Brl 52974 Family 2 27
Bacterial outer membrane Inhibitor HKI-9924129 Family 19 85
D(4) dopamine receptor Ligand L-745,870 Family 30 205
Histamine H3 receptor Ligand SCH79687 Family 11 29
Cyclin-dependent kinase 1 Inhibitor CGP-60474 Family 14 103
Epidermal growth factor receptor Ligand N4-(3-chlorophenyl)qui... 7 39
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 19 103
Sodium-dependent serotonin transporter Inhibitor 6-chloro-2-pi... 5 35
Melanocortin receptor Ligand Ac-his-dphe(3,4-dicl)-arg-trp-nh2... 10 14
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand 6-(4-... 3 6
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 8 12
Adenosine kinase inhibitor 5-(4-chlorophenyl)-6-[2-(6-morpholi... 8 8
Dipeptidyl peptidase 9 and Dipeptidyl peptidase 8 inhibitor Su... 16 5
RAC-alpha serine/threonine-protein kinase inhibitor (2S)-3-ami... 2 0
Cell division cycle 7-related protein kinase and Cyclin-depend... 2 9
RAC-alpha serine/threonine-protein kinase inhibitor 2-[(3,4-di... 3 1
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-09QM1E family 8 15
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-0A9QGC ... 14 0
Vascular endothelial growth factor receptor 2 ligand (3Z)-3-[5... 4 11
C-C chemokine receptor type 4 ligand [4-[4-[(2,4-dichloropheny... 4 4
Translocator protein inhibitor N-butan-2-yl-4-(2-chlorophenyl)... 14 12
Mitogen-activated protein kinase 14 inhibitor pyrimido-pyrimid... 15 0
Tyrosine-protein kinase Lck inhibitor AGN-PC-0762YG family 2 2
RAC-alpha serine/threonine-protein kinase and RAC-gamma serine... 2 0
P2X purinoceptor 7 inhibitor SureCN109432 family 10 28
Dipeptidyl peptidase 4 inhibitor (4R,5R)-5-amino-1-[6-(3-methy... 2 5
Adenosine kinase inhibitor 4-[2-[5-(4-chlorophenyl)-6-piperazi... 3 1
RAF proto-oncogene serine/threonine-protein kinase and Serine/... 4 3
Nitric oxide synthase, inducible inhibitor N-[(4-chlorophenyl)... 2 1
P2X purinoceptor 7 inhibitor N-[1-[(Z)-[(cyanoamino)-(quinolin... 3 3
Cannabinoid receptor 1 ligand AGN-PC-077JWI family 7 1
Melanin-concentrating hormone receptor 1 ligand (E)-3-(4-chlor... 3 7
Melanin-concentrating hormone receptor 1 ligand (E)-3-(4-chlor... 6 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00376636 CHEMBL1632372 Bioactive SureCN14305691
CFAMM00376642 CHEMBL1632381 Bioactive 2-[(4-chlorophenyl)methyl]-1-[4-[(5S)-5-methyl-5,7-dihydrothieno[3,4-d]pyrimidin-4-yl]piperazin-1-yl]-3-pyrrolidin-1-ylpropan-1-one
CFAMM00376635 CHEMBL1632375 Bioactive (2R)-2-amino-3-(4-chloro-3-fluorophenyl)-1-[4-[(5S)-5-methyl-5,7-dihydrothieno[3,4-d]pyrimidin-4-yl]piperazin-1-yl]propan-1-one
CFAMM00376641 CHEMBL1632384 Bioactive (2S)-2-[(4-chlorophenyl)methyl]-1-[4-[(5S)-5-methyl-5,7-dihydrothieno[3,4-d]pyrimidin-4-yl]piperazin-1-yl]-3-(propan-2-ylamino)propan-1-one
CFAMM00376640 CHEMBL1632386 Bioactive 2-[(1-aminocyclopropyl)methyl]-3-(4-chloro-3-fluorophenyl)-1-[4-[(5S)-5-methyl-5,7-dihydrothieno[3,4-d]pyrimidin-4-yl]piperazin-1-yl]propan-1-one
CFAMM00376633 CHEMBL1632388 Bioactive 4-amino-2-[(4-chloro-3-fluorophenyl)methyl]-4-methyl-1-[4-[(5S)-5-methyl-5,7-dihydrothieno[3,4-d]pyrimidin-4-yl]piperazin-1-yl]pentan-1-one
CFAMM00376639 CHEMBL1632387 Bioactive 4-amino-2-[(4-chlorophenyl)methyl]-4-methyl-1-[4-[(5S)-5-methyl-5,7-dihydrothieno[3,4-d]pyrimidin-4-yl]piperazin-1-yl]pentan-1-one
CFAMM00376632 CHEMBL1632368 Bioactive 2-[(4-chloro-3-fluorophenyl)methyl]-1-[4-[(5S)-5-methyl-5,7-dihydrothieno[3,4-d]pyrimidin-4-yl]piperazin-1-yl]-3-(propan-2-ylamino)propan-1-one
CFAMM00376638 CHEMBL1632371 Bioactive SureCN2577753
CFAMM00376637 CHEMBL1632373 Bioactive SureCN2578031
CFAMM00376643 CHEMBL1632380 Bioactive 2-[(4-chlorophenyl)methyl]-1-[4-[(5S)-5-methyl-5,7-dihydrothieno[3,4-d]pyrimidin-4-yl]piperazin-1-yl]-3-(propan-2-ylamino)propan-1-one

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27518 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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