CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM7035
Family Name RAC-alpha serine/threonine-protein kinase inhibitor 2-[(3,4-difluorophenyl)methyl]-1-[4-[(5S)-5-methyl-5,7-dihydrothieno[3,4-d]pyrimidin-4-yl]piperazin-1-yl]-3-(propan-2-ylamino)propan-1-one family
No. of Seeds 3 No. of Other Members 1
Family Centroid CFAMM00376646 Functional Category Bioactive with Natural Product
Superfamily Mitogen-activated protein kinase 9 and Mitogen-activated protein kinase 8 Binder Superfamily
Class Class 4519

Cousin Family NamesSeedsMembers
Gamma-aminobutyric acid A receptor Ligand imidazopyridine deri... 5 644
Calcitonin gene-related peptide type 1 receptor Ligand Telcage... 25 124
Cyclin-dependent kinase 4 Inhibitor PD-332991 Family 13 155
Translocator protein Inhibitor Emapunil Family 7 89
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
Protein kinase C alpha type and Protein kinase C beta type Inh... 16 86
RAC-gamma serine/threonine-protein kinase Inhibitor GDC-0068 F... 20 29
Histone deacetylase 6 Inhibitor ACY-1215 Family 10 230
JAK Inhibitor Momelotinib Family 33 83
Epidermal growth factor receptor and Receptor tyrosine-protein... 11 138
Adenosine receptor A3 Ligand 1-benzyl-1h-1,3,4b,9-tetraaza-flu... 19 165
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 19 103
D(2) dopamine receptor and D(3) dopamine receptor Ligand A-706... 4 20
Melanocortin receptor Ligand Ac-his-dnal(2)-arg-trp-nh2 Family 112 67
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Bombesin receptor subtype-3 and Gastrin-releasing peptide rece... 42 7
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 8 12
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 1 3
C-C chemokine receptor type 5 ligand [3-[2-[(3aS,6aR)-5-(4,6-d... 3 40
Platelet-activating factor receptor ligand 8-bromo-2-[4-(2-met... 2 2
Substance-P receptor ligand (3R,4S)-N-[[3,5-bis(trifluoromethy... 3 7
Cathepsin K and Potassium voltage-gated channel subfamily H me... 4 7
RAC-alpha serine/threonine-protein kinase and Proline-rich AKT... 2 4
Cell division cycle 7-related protein kinase inhibitor pyrrolo... 4 10
5-hydroxytryptamine receptor 1A ligand AGN-PC-03ZB72 family 10 8
Mitogen-activated protein kinase 1 and Cytochrome P450 3A4 inh... 1 0
Survival motor neuron protein and Menin inhibitor CHEMBL151109... 1 11
RAC-alpha serine/threonine-protein kinase inhibitor 2-[(4-chlo... 11 2
C-C chemokine receptor type 5 and Potassium voltage-gated chan... 21 32
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2206623 family 10 11
3-phosphoinositide-dependent protein kinase 1 and RAC-alpha se... 10 4
Vascular endothelial growth factor receptor 2 ligand (3Z)-3-[5... 4 11
Translocator protein inhibitor N-butan-2-yl-4-(2-chlorophenyl)... 14 12
Dipeptidyl peptidase 4 inhibitor [(2S,4S)-4-(4-quinolin-2-ylpi... 1 0
Dipeptidyl peptidase 4 inhibitor [(2S,4S)-4-(4-isoquinolin-1-y... 3 2
RAC-alpha serine/threonine-protein kinase and RAC-gamma serine... 2 0
Dipeptidyl peptidase 4 inhibitor (4R,5R)-5-amino-1-[6-[2-(trif... 1 0
Dipeptidyl peptidase 4 inhibitor (4R,5R)-5-amino-1-[6-(3-methy... 2 5
Dipeptidyl peptidase 4 inhibitor (4R,5R)-5-amino-1-(6-pyrrolid... 3 0
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 2 2
Orexin receptor type 2 and Orexin receptor type 1 ligand (2R)-... 12 16
Dipeptidyl peptidase 4 and Cytochrome P450 2D6 inhibitor (3R)-... 4 12
Serine/threonine-protein kinase mTOR inhibitor 1-ethyl-3-[4-[6... 4 1
Orexin receptor type 2 and Orexin receptor type 1 ligand 9-(4,... 2 8
C-C chemokine receptor type 5 ligand N-[3-[4-[3-cyclohexyl-5-(... 5 4
Eukaryotic translation initiation factor 2-alpha kinase 3 and ... 4 0
Histone deacetylase 1 inhibitor 1-methyl-N-[(1S)-7-oxo-1-(5-qu... 2 3
Histone deacetylase 1 inhibitor 1-methyl-N-[(1S)-7-oxo-1-(5-qu... 2 1
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 0
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 4 2
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 4 3
Nitric oxide synthase, inducible inhibitor N-[(4-chlorophenyl)... 2 1
Epidermal growth factor receptor ligand (E)-5-[4-(3-bromoanili... 11 0
Cyclin-dependent kinase 2 and Potassium voltage-gated channel ... 12 7
Cathepsin S and Cathepsin K inhibitor 2-cyano-N-[(2R)-1-phenyl... 2 0
Tyrosine-protein kinase SYK and Tyrosine-protein kinase ZAP-70... 3 0
Cyclin-dependent kinase 2 inhibitor SureCN3549598 family 3 1
Mast/stem cell growth factor receptor Kit and Tyrosine-protein... 4 1
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor (3... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00376648 CHEMBL1632377 Bioactive SureCN2579303
CFAMM00376647 CHEMBL1632382 Bioactive 1-[4-[(5S)-5-methyl-5,7-dihydrothieno[3,4-d]pyrimidin-4-yl]piperazin-1-yl]-2-[(4-methylphenyl)methyl]-3-(propan-2-ylamino)propan-1-one
CFAMM00376646 CHEMBL1632383 Bioactive 2-[(3,4-difluorophenyl)methyl]-1-[4-[(5S)-5-methyl-5,7-dihydrothieno[3,4-d]pyrimidin-4-yl]piperazin-1-yl]-3-(propan-2-ylamino)propan-1-one

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26240 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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