CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM7036
Family Name Histamine H4 receptor ligand (2Z)-5-chloro-2-[(1-methylpiperidin-4-yl)-nitrosomethylidene]-1,3-dihydrobenzimidazole family
No. of Seeds 2 No. of Other Members 8
Family Centroid CFAMM00251408 Functional Category Bioactive
Superfamily Histamine H4 receptor and Niemann-Pick C1 protein Binder Superfamily
Class Class 4520

Cousin Family NamesSeedsMembers
Alpha-2 adrenergic receptor Ligand Dexmedetomidine Family 32 639
Benzodiazepine receptor Ligand Midazolam Family 5 160
Histamine H1 receptor Ligand Mizolastine Family 14 603
C-X-C chemokine receptor type 4 Ligand AMD-070 Family 12 800
Fibroblast growth factor receptor 2 and Fibroblast growth fact... 11 86
Cannabinoid receptor 1 Ligand CP-945598 Family 18 173
HCV NS4B protein Inhibitor Clemizole Family 2 43
Tryptase Inhibitor Babim Family 12 90
Histamine H3 receptor and Histamine H4 receptor Ligand Clobenp... 31 38
D(4) dopamine receptor Ligand L-745,870 Family 30 205
Histamine H3 receptor Ligand SCH79687 Family 11 29
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2,6-di... 13 14
Adenosine receptor A3 Ligand 2,6-bis(4-chlorophenyl)-9h-purine... 4 12
Vascular endothelial growth factor receptor 2 Ligand 6-(1h-ben... 2 5
Arachidonate 5-lipoxygenase Inhibitor 2,4,5-triarylimidazole A... 3 16
Telomerase reverse transcriptase Inhibitor HOE-33258 Family 10 33
Alpha-1A adrenergic receptor Ligand A-315456 Family 7 17
Adenosine receptor A3 Ligand 2-(5-chloro-1h-benzo[d]imidazol-2... 7 51
Adenosine receptor A3 Ligand 2-(4-nitro-1h-benzo[d]imidazol-2-... 2 12
Proto-oncogene tyrosine-protein kinase Src Inhibitor BMS-27970... 41 59
Dipeptidyl peptidase 4 Inhibitor (5-phenyl-3h-benzo[d]imidazol... 5 13
Aromatase and Cytochrome P450 26A1 Inhibitor Liarozole Family 4 1
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Glycogen synthase kinase-3 beta Inhibitor CHIR-98023 Family 5 6
Cytochrome P450 11B1, mitochondrial Inhibitor 1-(4-bromobenzyl... 3 0
Sodium channel protein type 1 subunit alpha and Sodium channel... 10 14
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 4 3
Melanin-concentrating hormone receptor 1 and Potassium voltage... 8 27
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 1
Lysosomal Pro-X carboxypeptidase inhibitor 2-amino-N-[(2S)-1-[... 11 16
D(4) dopamine receptor and D(2) dopamine receptor ligand 4-met... 13 8
Nociceptin receptor and Kappa-type opioid receptor ligand 1-[1... 4 4
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 5 0
Transient receptor potential M8 protein ligand 2-[(E)-2-(oxan-... 5 3
Bile acid receptor and Potassium voltage-gated channel subfami... 2 1
Lysosomal Pro-X carboxypeptidase inhibitor N-[(1S)-1-(5,6-dich... 3 21
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 6 14
Cannabinoid receptor 1 ligand SureCN675796 family 5 1
Sodium-dependent dopamine transporter and Sodium-dependent nor... 2 3
Mitogen-activated protein kinase 14 inhibitor 6-[5-(2,4-difluo... 9 3
Histamine H4 receptor and Histamine H3 receptor ligand (E)-[(3... 4 3
Neuronal acetylcholine receptor subunit beta-2 and Neuronal ac... 10 6
Platelet-derived growth factor receptor beta and Vascular endo... 5 12
Cannabinoid receptor 2 ligand 8-(2-chlorophenyl)-9-cyclopropyl... 4 5
Dipeptidyl peptidase 4 inhibitor [(2S,4S)-4-[4-(1H-benzimidazo... 3 5
Mitogen-activated protein kinase 14 inhibitor 6-[2-(2,6-difluo... 3 0
Urokinase plasminogen activator surface receptor ligand 3-(1H-... 4 0
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 6 5
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 6 3
Neuropeptide Y receptor type 5 ligand SureCN6835211 family 1 2
Coagulation factor X inhibitor SureCN1652469 family 2 1
Serine/threonine-protein kinase Chk1 inhibitor CHIR-124 family 1 0
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 2 0
Nociceptin receptor and Mu-type opioid receptor ligand 2-(3-ch... 2 0
Pteridine reductase, putative inhibitor 1-[(3,4-dichlorophenyl... 2 1
Platelet-derived growth factor receptor beta and Fibroblast gr... 10 0
5-hydroxytryptamine receptor 2B ligand SureCN1299053 family 1 1
Small conductance calcium-activated potassium channel protein ... 1 0
Niemann-Pick C1 protein and Ras-related protein Rab-9A inhibit... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name


Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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