CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM7044
Family Name Serine/threonine-protein kinase D3 and Protein kinase C delta type inhibitor 3-[3-(4-naphthalen-1-yl-2,5-dioxopyrrol-3-yl)indol-1-yl]propyl carbamimidothioate;hydrobromide family
No. of Seeds 3 No. of Other Members 0
Family Centroid CFAMM00376680 Functional Category Bioactive
Superfamily Coagulation factor X and Coagulation factor IX Binder Superfamily 2
Class Class 1481

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 14 2769
Gastrin/cholecystokinin type B receptor ligand peptide Pentaga... 26 1171
Somatostatin receptor type 2 ligand octapeptide Octreotide Family 27 172
Hepatocyte growth factor receptor Ligand Arq 197 Family 10 400
Glycogen synthase kinase-3 beta and Protein kinase C beta type... 5 53
Cholecystokinin receptor type A Ligand Tarazepide Family 6 323
Poly [ADP-ribose] polymerase 1 Inhibitor AG-14699 Family 13 179
Mitogen-activated protein kinase 14 Inhibitor Losmapimod Family 5 154
Growth hormone receptor Ligand EP-51216 Family 34 390
Histone deacetylase 1 Inhibitor Panobinostat Family 5 93
D(3) dopamine receptor Ligand SB-277011 Family 13 178
Protein kinase C alpha type and Protein kinase C beta type Inh... 16 86
TGF-beta receptor type-1 Ligand LY2157299 Family 13 56
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
Lethal factor Inhibitor GM6001 Family 50 435
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 1-(9h-... 4 25
Cannabinoid receptor 2 Ligand JWH-167 Family 25 168
Somatostatin receptor type 2 Ligand L-054852 Family 13 88
Carbonic anhydrase 2 Inhibitor N-[2-(1h-indol-5-yl)-butyl]-4-s... 12 70
Cyclin-dependent kinase 1 and G2/mitotic-specific cyclin-B1 In... 2 0
Poly [ADP-ribose] polymerase 1 Inhibitor 1,7,8,9-tetrahydro-1,... 19 64
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[n... 12 10
Cholecystokinin receptor type A Ligand VL-0395 Family 12 117
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-methyl-1h... 24 50
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-3... 37 1
Adenosine receptor A3 Ligand 2-benzyl-2h-pyrazolo[3,4-c]quinol... 3 11
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[c... 20 18
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 5-... 4 10
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 3 29
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 3 27
Endothelin B receptor Ligand IRL-2500 Family 34 87
Vasopressin V1a receptor and Vasopressin V1b receptor Ligand D... 10 19
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 12 72
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Acetylcholinesterase and Cholinesterase Inhibitor 3-(2-diethyl... 12 160
Histone deacetylase Inhibitor ST-5732 Family 8 6
Bombesin receptor subtype-3 and Gastrin-releasing peptide rece... 42 7
Dipeptidyl peptidase 4 inhibitor (1S,3S,5S)-2-[(2S)-2-amino-2-... 3 5
Huntingtin and Glycogen synthase kinase-3 beta inhibitor SB 21... 2 4
Glycogen synthase kinase-3 beta and Protein kinase C alpha typ... 3 1
Glycogen synthase kinase-3 beta and Glycogen synthase kinase-3... 2 1
Neuropeptide S receptor and Prelamin-A/C ligand CHEMBL1367658 ... 1 7
Glycogen synthase kinase-3 beta inhibitor AGN-PC-07ZA4D family 1 0
Growth hormone secretagogue receptor type 1 ligand 2-amino-N-[... 1 0
Vascular endothelial growth factor receptor 2 and Receptor-typ... 7 4
Sodium-dependent serotonin transporter and Sodium-dependent do... 10 2
Survival motor neuron protein and Nonstructural protein 1 inhi... 1 18
Survival motor neuron protein and Menin inhibitor CHEMBL151109... 1 11
Serine/threonine-protein kinase D3 and Protein kinase C delta ... 3 10
Glycogen synthase kinase-3 beta and Tyrosine-protein kinase JA... 1 0
Protein kinase C beta type and Protein kinase C delta type inh... 1 2
Renin and Potassium voltage-gated channel subfamily H member 2... 9 2
Glycogen synthase kinase-3 alpha and Glycogen synthase kinase-... 1 0
Glycogen synthase kinase-3 beta inhibitor 3-(2-bromoacetyl)-4-... 1 0
Glycogen synthase kinase-3 alpha and Glycogen synthase kinase-... 2 0
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 1
Neuropeptide Y receptor type 5 ligand 2-indol-1-yl-N-[4-[(prop... 7 6
Orexin receptor type 1 and Orexin receptor type 2 ligand N-[[(... 9 5
Dipeptidyl peptidase 4 inhibitor [(2S,4S)-4-(4-quinolin-4-ylpi... 5 8
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand N-(1-... 2 0
Vascular endothelial growth factor receptor 2 and Angiopoietin... 14 0
RAC-beta serine/threonine-protein kinase and 3-phosphoinositid... 11 4
Coagulation factor X inhibitor 3-chloro-N-[(1S,2S)-2-[[4-(2-ox... 22 3
Phospholipase D1 and Phospholipase D2 inhibitor SureCN10311349... 2 14
Platelet-activating factor receptor ligand (1-ethylindol-3-yl)... 17 13
Platelet-activating factor receptor ligand N,N-diethyl-3-[(4R)... 11 0
Platelet-activating factor receptor ligand (4R)-N-(3-benzoylph... 2 1
Substance-P receptor and Substance-K receptor ligand N-methyl-... 2 2
Sodium-dependent serotonin transporter and D(2) dopamine recep... 1 0
Serine/threonine-protein kinase Chk1 inhibitor SureCN6080935 f... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00376680 CHEMBL163269 Bioactive 3-[3-(4-naphthalen-1-yl-2,5-dioxopyrrol-3-yl)indol-1-yl]propyl carbamimidothioate;hydrobromide
CFAMM00376679 CHEMBL444864 Bioactive 3-[3-(2,5-dioxopyrrol-3-yl)-2-naphthalen-2-ylindol-1-yl]propyl carbamimidothioate;hydrobromide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

24517 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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