CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM7078
Family Name Potassium voltage-gated channel subfamily H member 2 and Melanin-concentrating hormone receptor 1 ligand AGN-PC-09QH1S family
No. of Seeds 9 No. of Other Members 4
Family Centroid CFAMM00376969 Functional Category Bioactive
Superfamily Melanin-concentrating hormone receptor 1 and Potassium voltage-gated channel subfamily H member 2 Binder Superfamily
Class Class 2417

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1A Ligand (s)-way 100135 Family 94 975
Muscarinic acetylcholine receptor M1 Ligand AC-260584 Family 4 36
C-C chemokine receptor type 1 Ligand BX-471 Family 10 67
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Cilost... 6 202
5-hydroxytryptamine receptor 1A Ligand NAN-190 Family 14 28
Leukotriene A-4 hydrolase Inhibitor N5-[4-(phenylmethoxy)pheny... 7 49
Leukotriene A-4 hydrolase Inhibitor N-benzyl-4-[(2r)-pyrrolidi... 6 40
5-hydroxytryptamine receptor 1A and Alpha-1A adrenergic recept... 18 12
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 6 23
Histamine H3 receptor Ligand A-349821 Family 49 228
Substance-K receptor Ligand MEN-14933 Family 13 154
Alpha-1A adrenergic receptor Ligand Upidosin Family 8 46
Alpha-1A adrenergic receptor Ligand Ro-11-04253 Family 1 1
Cannabinoid receptor 1 Ligand N-(4-methoxyphenyl)oleamide Family 4 23
Alpha-1A adrenergic receptor and D(2) dopamine receptor Ligand... 5 49
Macrophage migration inhibitory factor Inhibitor 3-benzyl-5-me... 10 42
Amine oxidase [flavin-containing] B Inhibitor N-methyl-n-pheny... 6 25
5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine ... 9 79
Renin Inhibitor Ro-66-1168 Family 10 30
Bifunctional epoxide hydrolase 2 Inhibitor 1-(3-(3-morpholinop... 24 102
5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine ... 8 41
Leukotriene A-4 hydrolase Inhibitor 1-[4-(4-iodophenoxy)phenyl... 5 18
Galanin receptor type 1 and Galanin receptor type 2 Ligand Gal... 55 132
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 21 13
Reverse transcriptase Inhibitor 10-propyl-10h-dibenzo[b,f][1,4... 9 60
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 2 7
Tyrosinase Inhibitor 1-(4-(benzyloxy)phenyl)-3-hydroxyurea Family 9 23
Fatty-acid amide hydrolase 1 Inhibitor 4-nitrophenyl 4-benzylp... 5 35
Liver carboxylesterase 1 Inhibitor SCH-48375 Family 2 28
Tubulin beta chain Inhibitor Gnf-pf-117 Family 2 16
D(4) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 2 1
Substance-P receptor ligand N-[1-[acetyl-[(2-methoxyphenyl)met... 3 9
Cathepsin K inhibitor N-[(2S)-1-(4-methoxyanilino)propan-2-yl]... 11 10
D(2) dopamine receptor ligand 7-[4-[4-(2-ethoxyphenyl)piperazi... 12 14
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 4 2
D(3) dopamine receptor and D(2) dopamine receptor ligand (E)-3... 2 3
Histamine H3 receptor and Potassium voltage-gated channel subf... 3 4
Renin inhibitor 6-[[(2R)-1-[4-[3-[(2-methoxyphenyl)methoxy]pro... 3 1
D(3) dopamine receptor and D(2) dopamine receptor ligand (E)-N... 2 2
D(4) dopamine receptor and D(2) dopamine receptor ligand SureC... 4 3
D(4) dopamine receptor and D(3) dopamine receptor ligand SureC... 5 0
C5a anaphylatoxin chemotactic receptor 1 ligand N-[(4-dimethyl... 1 4
Melanin-concentrating hormone receptor 1 ligand 1-[1-(1-methyl... 5 10
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 2 0
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 4 1
Androgen receptor ligand (2R)-2-ethyl-1-(2,2,2-trifluoroethyl)... 32 6
Histamine H3 receptor ligand SureCN1373218 family 2 2
Histamine H3 receptor ligand 1-methyl-5-[4-[3-[(2R)-2-methylpy... 5 5
Histamine H3 receptor ligand 5-[4-[3-[(2R)-2-methylpyrrolidin-... 2 3
Renin and Cytochrome P450 3A4 inhibitor SureCN6719989 family 2 0
Translocator protein inhibitor AGN-PC-00CH84 family 3 0
Translocator protein inhibitor [11C]DAA1106 family 15 2
Translocator protein inhibitor N-methyl-2-[2-oxo-5-[4-(trifluo... 9 3
Receptor-type tyrosine-protein kinase FLT3 ligand (3Z)-5-chlor... 1 4
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 6 11
C-C chemokine receptor type 1 ligand N-[2-[(2S)-2-amino-3-(5-f... 3 0
Histamine H3 receptor and Histamine receptor H3 ligand 1-[4-[3... 2 0
Poly [ADP-ribose] polymerase 1 inhibitor 6-[[4-(4-chlorophenyl... 1 0
Matrix metalloproteinase-9 and 72 kDa type IV collagenase inhi... 20 23
Urotensin-2 receptor and Kappa-type opioid receptor ligand 6,7... 2 0
Urotensin-2 receptor and Cytochrome P450 3A4 ligand 5-chloro-3... 2 1
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 2 0
Neuropeptide Y receptor type 5 ligand 1-[1-(4-fluorophenyl)pro... 2 8
Sigma non-opioid intracellular receptor 1 ligand (5S)-5-[(4-hy... 1 5
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-00RZQT family 3 4
Melanin-concentrating hormone receptor 1 ligand AGN-PC-07CR9C ... 10 7
Acyl-CoA desaturase and Acyl-CoA desaturase 1 inhibitor SureCN... 1 0
Poly [ADP-ribose] polymerase 1 inhibitor SureCN8058778 family 13 4
3-oxo-5-alpha-steroid 4-dehydrogenase 1 inhibitor AGN-PC-007ZS... 3 3
P2X purinoceptor 7 inhibitor SureCN3722920 family 4 0
Metabotropic glutamate receptor 2 ligand (5R)-3-[[4-(4-ethoxyp... 3 9
3-oxo-5-alpha-steroid 4-dehydrogenase 1 inhibitor AGN-PC-04F7M... 1 3
Endothelin B receptor and Endothelin-1 receptor ligand AGN-PC-... 3 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00376978 CHEMBL584538 Bioactive AGN-PC-00DHQO
CFAMM00376970 CHEMBL1642476 Bioactive AGN-PC-09QLIQ
CFAMM00376969 CHEMBL1642471 Bioactive AGN-PC-09QH1S
CFAMM00376968 CHEMBL1642472 Bioactive AGN-PC-09QH1T
CFAMM00376967 CHEMBL1642479 Bioactive AGN-PC-09QH1U
CFAMM00376973 CHEMBL1642475 Bioactive SureCN2892570
CFAMM00376972 CHEMBL1642474 Bioactive AGN-PC-09QKIU
CFAMM00376979 CHEMBL1642487 Bioactive AGN-PC-09QJNE
CFAMM00376971 CHEMBL1642477 Bioactive AGN-PC-09QHX7

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27277 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543