CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM7081
Family Name Inhibitor of nuclear factor kappa-B kinase subunit beta and Inhibitor of nuclear factor kappa-B kinase subunit alpha inhibitor CHEMBL1642545 family
No. of Seeds 5 No. of Other Members 27
Family Centroid CFAMM00292161 Functional Category Bioactive
Superfamily and Adenosine receptor A2b Binder Superfamily
Class Class 3914

Cousin Family NamesSeedsMembers
Toll-like receptor 7 Ligand Imiquimod Family 3 237
Aurora kinase B and Aurora kinase C Inhibitor SNS-314 Family 2 75
Aurora kinase B and Aurora kinase A Inhibitor CYC116 Family 16 135
C-X-C chemokine receptor type 4 Ligand AMD-070 Family 12 800
Cyclin-dependent kinase 2 Inhibitor Seliciclib Family 29 292
Fibroblast growth factor receptor 2 and Fibroblast growth fact... 11 86
Cytochrome P450 26A1 Inhibitor Rambazole Family 7 77
Steroid 17-alpha-hydroxylase/17,20 lyase Inhibitor 1-(1-(4-thi... 3 36
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2,6-di... 13 14
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... 18 109
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 4 22
Epidermal growth factor receptor Ligand PD-158780 Family 98 89
Adenosine receptor A2a and Adenosine receptor A3 Ligand 5-buty... 3 18
Adenosine receptor A1 Ligand Phenyl-(9-phenyl-9h-purin-6-yl)-a... 7 12
Mitogen-activated protein kinase 14 and Tyrosine-protein kinas... 1 9
Mitogen-activated protein kinase 3 and RAF proto-oncogene seri... 8 5
Mitogen-activated protein kinase 14 Inhibitor 9-benzyl-6-pheny... 5 33
TGF-beta receptor type-1 Ligand 4-pyridin-2-yl-5-quinolin-4-yl... 4 23
RAC-gamma serine/threonine-protein kinase and Rho-associated p... 16 46
Metabotropic glutamate receptor 5 Ligand 4-(4-chlorophenylthio... 4 17
Inhibitor of nuclear factor kappa-B kinase subunit beta Inhibi... 6 64
C-C chemokine receptor type 4 Ligand N-(4-tert-butylthiazol-2-... 3 9
Cyclin-dependent kinase 5 Inhibitor 1-phenyl-3-(2-(pyridin-4-y... 3 53
5-hydroxytryptamine receptor 2B and 5-hydroxytryptamine recept... 7 15
Glycogen synthase kinase-3 beta and Mitogen-activated protein ... 4 23
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-chlo... 11 20
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-ethy... 2 2
Histamine H4 receptor Ligand A-943931 Family 14 11
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Poly [ADP-ribose] polymerase 1 Inhibitor N-(4-phenylthiazol-2-... 6 150
Hepatocyte growth factor receptor Ligand 3-(phenylsulfonyl)-1h... 17 59
Type-2 angiotensin II receptor Ligand L-158809 Family 22 136
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 4 22
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 6 55
Sodium channel protein type 1 subunit alpha and Sodium channel... 10 14
Cytochrome P450 2D6 and Cytochrome P450 3A4 Inhibitor 2-(2-(4-... 25 10
Aurora kinase B and Aurora kinase A inhibitor AGN-PC-07ZBLC fa... 3 8
Potassium voltage-gated channel subfamily H member 2 and Neuro... 2 3
Histamine H3 receptor and Potassium voltage-gated channel subf... 2 4
Cyclin-T1 and Cyclin-dependent kinase 9 inhibitor 2-[3-(4-acet... 4 12
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 4 2
Receptor tyrosine-protein kinase erbB-2 ligand AGN-PC-07ZDR2 f... 7 33
5-hydroxytryptamine receptor 6 ligand AGN-PC-03P3TZ family 6 88
Neuropeptide Y receptor type 5 ligand N-[[(1S,5R)-3-(1-phenyle... 5 1
Neuropeptide Y receptor type 5 ligand 2-phenyl-1-[(1R,5S)-6-[[... 9 11
Mitogen-activated protein kinase 14 inhibitor AGN-PC-07ZXHN fa... 2 4
Vascular endothelial growth factor receptor 2 and Mast/stem ce... 10 27
5-hydroxytryptamine receptor 6 ligand 6-chloro-5-[1-(1-methylp... 9 0
Mitogen-activated protein kinase 14 and LIM domain kinase 1 in... 4 19
Serine/threonine-protein kinase Chk1 inhibitor 2-(1-methylindo... 3 4
DNA-(apurinic or apyrimidinic site) lyase and Neuropeptide S r... 1 4
Thyroid hormone receptor beta and Ferritin light chain ligand ... 3 10
Inosine-5'-monophosphate dehydrogenase and Nuclear receptor RO... 2 9
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 3 10
Adenosine kinase inhibitor SureCN8183719 family 2 3
Epidermal growth factor receptor ligand AGN-PC-07C2E2 family 7 6
Growth hormone secretagogue receptor type 1 and Dihydrofolate ... 3 6
Cell division cycle 7-related protein kinase inhibitor AGN-PC-... 6 6
Platelet-activating factor receptor ligand Foropafant family 2 0
Fatty-acid amide hydrolase 1 inhibitor AGN-PC-0A9RCZ family 7 7
Mitogen-activated protein kinase 10 and Mitogen-activated prot... 2 18
Calcitonin gene-related peptide type 1 receptor ligand SureCN1... 2 0
Fatty-acid amide hydrolase 1 inhibitor 5-[5-(4-chlorophenyl)su... 2 4
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 7 21
Histamine H4 receptor ligand 8-chloro-4-[(3R)-3-(methylamino)p... 3 10
Histamine H4 receptor ligand 8-bromo-4-(4-methylpiperazin-1-yl... 2 1
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2206623 family 10 11
Mitogen-activated protein kinase 14 inhibitor N-[4-[2-ETHYL-4-... 4 5
TGF-beta receptor type-1 ligand 6-[(5E)-5-(4-methyl-3H-1,3-thi... 22 9
Adenosine receptor A2b and Adenosine receptor A3 ligand 3-[5-(... 4 2
Serine/threonine-protein kinase Chk1 inhibitor 3-[5-[2-[(4-mor... 2 3
Serine/threonine-protein kinase Chk1 inhibitor 5-[5-(1-methylp... 3 2
TGF-beta receptor type-1 and Mitogen-activated protein kinase ... 6 4
Vascular endothelial growth factor receptor 2 and Vascular end... 4 1
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2152398 family 16 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 6 2
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2206614 family 2 0
Vascular endothelial growth factor receptor 2 ligand N-(1,3-Th... 4 4
Adenosine receptor A1 ligand N-butyl-5-phenyl-3-[[2-(trifluoro... 7 2
Cyclin-T1 and Cyclin-dependent kinase 9 inhibitor 2-[3-(1,4-di... 3 3
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 2 7
Dual specificity tyrosine-phosphorylation-regulated kinase 1A ... 7 7
Orexin receptor type 2 and Orexin receptor type 1 ligand 6-ami... 3 1
Glucocorticoid receptor ligand 3-[1-(4-fluorophenyl)imidazo[1,... 5 3
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 3 6
Trans-2-enoyl-ACP reductase II inhibitor AGN-PC-01LWZK family 3 0
Cathepsin K inhibitor SureCN4141224 family 3 0
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 2 1
Adenosine receptor A2a and Adenosine receptor A1 ligand [(2S)-... 2 0
Epidermal growth factor receptor and Vascular endothelial grow... 7 0
Epidermal growth factor receptor and Vascular endothelial grow... 3 1
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 1 0
C-C chemokine receptor type 2 ligand AGN-PC-0765RZ family 1 0
5-hydroxytryptamine receptor 6 ligand 8-(1-pyrrolidin-3-ylpyrr... 1 0
Adenosine receptor A2a and Adenosine receptor A2b ligand SureC... 4 5
Transient receptor potential cation channel subfamily V member... 9 13
Alpha-1A adrenergic receptor and Alpha-2A adrenergic receptor ... 1 0
RAC-alpha serine/threonine-protein kinase and RAC-gamma serine... 20 7
Tyrosine-protein kinase SYK and Tyrosine-protein kinase ZAP-70... 4 1
Transient receptor potential cation channel subfamily V member... 1 0
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 2 4
Dipeptidyl peptidase 4 and Cytochrome P450 2D6 inhibitor AGN-P... 1 0
Metabotropic glutamate receptor 1 and Metabotropic glutamate r... 5 0
Heat shock protein HSP 90-alpha and Heat shock protein HSP 90-... 4 16
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 5 1
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 1 2
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 3 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00377074 CHEMBL1642564 Bioactive CHEMBL1642564
CFAMM00377070 CHEMBL521643 Bioactive SureCN5657205

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

48709 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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