CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM7084
Family Name Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor N-[4-(cyanomethyl)cyclohexyl]-N-cyclopropyl-4-[(2R)-1,1,1-trifluoro-2-hydroxypropan-2-yl]benzamide family
No. of Seeds 30 No. of Other Members 10
Family Centroid CFAMM00377113 Functional Category Bioactive
Superfamily Corticosteroid 11-beta-dehydrogenase isozyme 1 and Prelamin-A/C Binder Superfamily
Class Class 3272

Cousin Family NamesSeedsMembers
D(2) dopamine receptor Ligand Haloperidol Family 5 53
Delta-type opioid receptor Ligand Bw 373u86 Family 31 146
Proto-oncogene tyrosine-protein kinase Src Inhibitor RU85053 F... 6 8
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 41 24
Angiotensin-converting enzyme Inhibitor N-carboxymethyl-n-cycl... 2 24
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 3 13
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 3 9
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 3 0
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 10 20
3-oxo-5-alpha-steroid 4-dehydrogenase 2 and 3-oxo-5-alpha-ster... 2 7
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor SureC... 6 5
Prostaglandin E2 receptor EP4 subtype and Prostaglandin E2 rec... 13 22
Malonyl-CoA decarboxylase, mitochondrial inhibitor [4-(1,1,1,3... 6 0
Dipeptidyl peptidase 4 inhibitor 3-[2-[(4R,5R)-5-amino-2-oxo-4... 1 4
C-C chemokine receptor type 1 ligand 4-chloro-N-[(2R)-1-[(4S)-... 6 3
Prostaglandin E2 receptor EP4 subtype and Prostaglandin E2 rec... 3 0
C-C chemokine receptor type 2 ligand 2-amino-N-[2-[[(3R)-1-[(4... 2 6
Delta-type opioid receptor and Kappa-type opioid receptor liga... 3 4
Neutrophil elastase inhibitor 3-[[(2S)-3-methyl-1-oxo-1-[2-[(1... 1 0
Malonyl-CoA decarboxylase, mitochondrial inhibitor 4-cyano-N-e... 1 2
Type-1B angiotensin II receptor ligand AGN-PC-074YOZ family 1 14
2-bromo-N-[(2R)-2-hydroxy-2-phenylethyl]-N-methylbenzamide NP ... 1 0


External ID

Functional Category

Molecule Name

CFAMM00377151 CHEMBL469698 Bioactive SureCN3236432
CFAMM00377126 CHEMBL1642598 Bioactive SureCN5484177
CFAMM00377144 CHEMBL491326 Bioactive N-[4-[(1-cyanocyclopropyl)methyl]cyclohexyl]-N-cyclopropyl-4-[(2S)-1,1,1-trifluoro-2-hydroxypropan-2-yl]benzamide
CFAMM00377113 CHEMBL2021494 Bioactive N-[4-(cyanomethyl)cyclohexyl]-N-cyclopropyl-4-[(2R)-1,1,1-trifluoro-2-hydroxypropan-2-yl]benzamide
CFAMM00377119 CHEMBL1642591 Bioactive SureCN5480313
CFAMM00377150 CHEMBL469699 Bioactive SureCN3231583
CFAMM00377143 CHEMBL205986 Bioactive 4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-N,N-bis(2-methylpropyl)benzamide
CFAMM00377118 CHEMBL460933 Bioactive SureCN14341187
CFAMM00377133 CHEMBL473347 Bioactive N-cyclopropyl-N-[4-(cyclopropylmethyl)-4-hydroxycyclohexyl]-4-[(2S)-1,1,1-trifluoro-2-hydroxypropan-2-yl]benzamide
CFAMM00377149 CHEMBL515717 Bioactive N-cyclopropyl-N-(4-hydroxy-4-propan-2-ylcyclohexyl)-4-[(2S)-1,1,1-trifluoro-2-hydroxypropan-2-yl]benzamide
CFAMM00377124 CHEMBL1642596 Bioactive SureCN5481609
CFAMM00377140 CHEMBL202746 Bioactive AGN-PC-00D2B5
CFAMM00377155 CHEMBL461292 Bioactive SureCN13431600
CFAMM00377123 CHEMBL1642597 Bioactive N-[4-(3-amino-3-oxopropyl)-4-(2-fluorophenyl)cyclohexyl]-N-cyclopropyl-4-[(2S)-1,1,1-trifluoro-2-hydroxypropan-2-yl]benzamide
CFAMM00377139 CHEMBL2021502 Bioactive CHEMBL2021493
CFAMM00377154 CHEMBL516968 Bioactive N-cyclohexyl-N-(2,2,2-trifluoroethyl)-4-[(2S)-1,1,1-trifluoro-2-hydroxypropan-2-yl]benzamide
CFAMM00377116 CHEMBL2021499 Bioactive N-[4-cyano-4-(4-fluorophenyl)cyclohexyl]-N-cyclopropyl-4-[(2R)-1,1,1-trifluoro-2-hydroxypropan-2-yl]benzamide
CFAMM00377147 CHEMBL463031 Bioactive SureCN3236983
CFAMM00377122 CHEMBL1642592 Bioactive SureCN14341204
CFAMM00377138 CHEMBL507804 Bioactive SureCN13431625
CFAMM00377153 CHEMBL454620 Bioactive N-[4-[(1-carbamoylcyclopropyl)methyl]cyclohexyl]-N-cyclopropyl-4-[(2S)-1,1,1-trifluoro-2-hydroxypropan-2-yl]benzamide
CFAMM00377115 CHEMBL518644 Bioactive SureCN5487077
CFAMM00377129 CHEMBL517760 Bioactive SureCN5477094
CFAMM00377146 CHEMBL202688 Bioactive N-benzyl-4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-N-methylbenzamide
CFAMM00377121 CHEMBL1642593 Bioactive SureCN5485140
CFAMM00377152 CHEMBL471930 Bioactive SureCN3231661
CFAMM00377137 CHEMBL444567 Bioactive AGN-PC-00QUGJ
CFAMM00377114 CHEMBL489320 Bioactive SureCN3223219
CFAMM00377145 CHEMBL508331 Bioactive SureCN13431623
CFAMM00377120 CHEMBL1642590 Bioactive SureCN14341191

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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