CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM7105
Family Name Prostaglandin D2 receptor 2 and Prostaglandin D2 receptor ligand 2-[(7R)-7-[ethyl-(4-fluorophenyl)sulfonylamino]-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]acetic acid family
No. of Seeds 20 No. of Other Members 37
Family Centroid CFAMM00143302 Functional Category Bioactive with Natural Product
Superfamily Prostaglandin D2 receptor 2 and Prostaglandin D2 receptor Binder Superfamily
Class Class 1029

Cousin Family NamesSeedsMembers
Indoleamine 2,3-dioxygenase 1 Inhibitor L-tryptophan Family 8 328
Thromboxane A2 receptor Ligand Ramatroban Family 13 49
Indeglitazar family 3 39
Potassium-competitive acid Inhibitor TAK-438 Family 2 8
Prostaglandin G/H synthase 2 Inhibitor L-761000 Family 8 44
Substance-P receptor ligand AGN-PC-01ZIXQ family 13 42
Thromboxane A2 receptor and Thromboxane-A synthase ligand AGN-... 4 19
NS5B protein inhibitor AC1NQMYG family 6 12
Prostaglandin G/H synthase 1 and Prostaglandin G/H synthase 2 ... 1 6
Prostaglandin D2 receptor and Thromboxane A2 receptor ligand S... 3 4
Prostaglandin D2 receptor 2 ligand 2-[(8R)-8-[(4-fluorophenyl)... 3 15
Prostaglandin D2 receptor 2 and Prostaglandin D2 receptor liga... 5 2
Prothrombin and Trypsin-1 inhibitor 1-[2-(4-benzylpiperidin-1-... 2 2
Prostaglandin D2 receptor 2 ligand SureCN2189431 family 7 1
NS5B protein inhibitor AC1NQMYP family 5 0
Prostaglandin G/H synthase 2 and Prostaglandin G/H synthase 1 ... 4 68
Translocator protein inhibitor N,N-diethyl-11-(2-fluoroethyl)-... 14 9
Egl nine homolog 1 inhibitor 2-[5-methyl-6-[[1-oxo-2-(4-phenyl... 4 3
Substance-P receptor ligand SureCN7796965 family 9 1
Substance-P receptor ligand SureCN7790374 family 6 0
Prostaglandin D2 receptor 2 ligand 2-[6-fluoro-3-(2-fluoro-4-m... 1 0
Neutrophil collagenase and Stromelysin-1 inhibitor (3R)-N-hydr... 2 0
Thromboxane A2 receptor and Thromboxane-A synthase ligand AGN-... 2 3


External ID

Functional Category

Molecule Name

CFAMM00377264 CHEMBL1643778 Bioactive 2-[(7R)-7-[(4-fluorophenyl)sulfonyl-methylamino]-3-phenyl-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]acetic acid
CFAMM00377284 CHEMBL1643789 Bioactive 2-[(7R)-7-[(4-fluorophenyl)methyl-(4-fluorophenyl)sulfonylamino]-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]acetic acid
CFAMM00377263 CHEMBL1643775 Bioactive 2-[(7R)-7-[(4-fluorophenyl)sulfonyl-methylamino]-3-(trifluoromethyl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]acetic acid
CFAMM00377261 CHEMBL1643777 Bioactive 2-[(7R)-7-[(4-fluorophenyl)sulfonyl-methylamino]-3-methylsulfonyl-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]acetic acid
CFAMM00377260 CHEMBL1643776 Bioactive 2-[(7R)-3-cyano-7-[(4-fluorophenyl)sulfonyl-methylamino]-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]acetic acid
CFAMM00377285 CHEMBL1643783 Bioactive 2-[(7R)-4-fluoro-7-[(4-fluorophenyl)sulfonyl-methylamino]-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]acetic acid

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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