CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM7132
Family Name Dipeptidyl peptidase 4 inhibitor 3-[6-[(3R,4S)-3-amino-4-(2,4,5-trifluorophenyl)pyrrolidin-1-yl]pyrimidin-4-yl]benzoic acid family
No. of Seeds 3 No. of Other Members 7
Family Centroid CFAMM00377391 Functional Category Bioactive with Natural Product
Superfamily Dihydrofolate reductase and Egl nine homolog 1 Binder Superfamily
Class Class 1253

Cousin Family NamesSeedsMembers
Type-1 angiotensin II receptor Ligand Telmisartan Family 4 181
Type-1 angiotensin II receptor Ligand Eprosartan Family 36 176
Prostaglandin G/H synthase 2 Inhibitor Niflumic Acid Family 7 119
Aurora kinase A Inhibitor MLN8054 Family 2 5
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 19 103
Mitogen-activated protein kinase 8 Inhibitor 2-(2-phenoxypyrim... 12 30
Arachidonate 5-lipoxygenase Inhibitor Methyl 2-(benzylamino)-1... 3 10
Proto-oncogene tyrosine-protein kinase Src Inhibitor 5,7-diphe... 2 11
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 8 12
Thymidylate synthase inhibitor (2R)-2-[[(4S)-4-carboxy-4-[[4-[... 55 43
Cathepsin K and Potassium voltage-gated channel subfamily H me... 4 7
Adenosine receptor A1 ligand AGN-PC-07PMLW family 6 4
Thymidylate synthase inhibitor AC1LAB7Z family 8 3
Dihydrofolate reductase and Thymidylate synthase inhibitor 2-[... 10 5
Dihydrofolate reductase inhibitor 2-[[4-carboxy-4-[[4-[(2,4-di... 3 1
Dihydrofolate reductase inhibitor AGN-PC-075RRH family 2 3
Bifunctional dihydrofolate reductase-thymidylate synthase inhi... 2 12
Prostaglandin D2 receptor ligand 2-[3-[6-[2-(2,4-dichloropheny... 7 2
NS5B protein inhibitor (2E)-1-cyclohexyl-2-(2-fluoro-4-oxocycl... 2 10
Scavenger receptor class B member 1 ligand methyl 9-[3-(4,6-di... 2 10
Egl nine homolog 2 and Egl nine homolog 1 inhibitor 3-methyl-4... 15 14
Growth hormone secretagogue receptor type 1 ligand SureCN62436... 8 6
Lysine--tRNA ligase inhibitor 4-[[2-(2-piperazin-1-ylpyridin-4... 2 0
Type-1A angiotensin II receptor ligand 2-[[2-butyl-3-[(4-carbo... 2 4
Dipeptidyl peptidase 4 inhibitor 2-[(3R)-3-aminopiperidin-1-yl... 7 15
Aurora kinase A and Cyclin-dependent kinase 4 inhibitor 2-[3-[... 1 0
Aurora kinase A inhibitor Bisanilinopyrimidine, 6i family 1 0
Aurora kinase A inhibitor Bisanilinopyrimidine, 6j family 2 1
Dipeptidyl peptidase 4 inhibitor (4R,5R)-5-amino-1-[6-(3-methy... 2 5
Dipeptidyl peptidase 4 and Cytochrome P450 2D6 inhibitor (3R)-... 4 12
Tyrosine-protein kinase JAK2 inhibitor 4-[[8-(1-propan-2-ylpyr... 5 6
Type-1A angiotensin II receptor and Type-1B angiotensin II rec... 3 6
Thromboxane-A synthase inhibitor AGN-PC-00NE8C family 2 3
Cyclin-dependent kinase 2 and Potassium voltage-gated channel ... 12 7
Type-1 angiotensin II receptor ligand 2-ethyl-4-[[4-[2-(2H-tet... 2 0
Aurora kinase A and Aurora kinase B inhibitor AGN-PC-071H3F fa... 3 0
Serine/threonine-protein kinase Sgk1 inhibitor SureCN3774571 f... 2 18
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 0
Ribosomal protein S6 kinase alpha-3 inhibitor AGN-PC-088WRP fa... 1 0
Type-1A angiotensin II receptor and Type-1B angiotensin II rec... 1 0
Diacylglycerol O-acyltransferase 1 inhibitor 2-[4-[4-(4-amino-... 2 3
Vascular endothelial growth factor receptor 1 and Vascular end... 1 0
Cellular tumor antigen p53 and Microtubule-associated protein ... 1 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00377398 CHEMBL1644217 Bioactive 3-[6-[2-(2,4-difluorophenyl)ethylamino]-2-methoxypyrimidin-4-yl]benzoic acid
CFAMM00377391 CHEMBL236508 Bioactive 3-[6-[(3R,4S)-3-amino-4-(2,4,5-trifluorophenyl)pyrrolidin-1-yl]pyrimidin-4-yl]benzoic acid
CFAMM00377397 CHEMBL245585 Bioactive AGN-PC-046QYR

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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