CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM7135
Family Name Prostaglandin D2 receptor ligand 1-[3-[2-methoxy-6-[2-(4-methoxyphenyl)ethylamino]pyrimidin-4-yl]phenyl]ethanone family
No. of Seeds 6 No. of Other Members 16
Family Centroid CFAMM00377432 Functional Category Bioactive with Natural Product
Superfamily Prelamin-A/C and Histamine H4 receptor Binder Superfamily
Class Class 2020

Cousin Family NamesSeedsMembers
Alpha-1D adrenergic receptor Ligand Terazosin Family 28 638
Epidermal growth factor receptor Ligand Gefitinib Family 26 600
Serine/threonine-protein kinase PLK1 Inhibitor Bi 6727 Family 15 81
Corticotropin-releasing factor receptor 1 Ligand CRF-1 Antagon... 29 421
Receptor tyrosine-protein kinase erbB-2 Inhibitor CP-724714 Fa... 4 180
Calcium-activated potassium channel subunit alpha-1 Ligand AVE... 3 284
Smoothened homolog Inhibitor LDE225 Family 3 76
SB1518 family 7 103
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 11 10
MK-6096 family 3 69
JAK Inhibitor Momelotinib Family 33 83
5-hydroxytryptamine receptor 1B Ligand GR55562 Family 3 45
Proto-oncogene tyrosine-protein kinase Src Inhibitor PD166285 ... 6 70
Tyrosine kinase Inhibitor PKI166 Family 17 198
5-hydroxytryptamine receptor 1A Ligand P-MPPI Family 33 81
Peptide deformylase, mitochondrial Inhibitor 5-(4-methoxypheno... 5 61
Angiopoietin-1 receptor and Tyrosine-protein kinase Lck Inhibi... 3 64
Integrin alpha-V and Integrin beta-1 Inhibitor SB-265123 Family 30 170
Adenosine receptor A1 and Adenosine receptor A3 Ligand 4-metho... 1 16
Peptidyl-prolyl cis-trans isomerase A Inhibitor 3-[3-(3-benzyl... 3 34
Melanin-concentrating hormone receptor 1 Ligand ADS-102891 Family 6 51
Mitogen-activated protein kinase 8 Inhibitor 2-(2-phenoxypyrim... 12 30
C-X-C chemokine receptor type 3 Ligand AMG-487 Family 28 73
Fatty-acid amide hydrolase 1 Inhibitor BMS-1 Family 5 22
Potassium voltage-gated channel subfamily H member 2 Ligand Be... 22 56
Adenosine receptor A1 and Adenosine receptor A2a Ligand N-(2-(... 21 108
Ribosyldihydronicotinamide dehydrogenase [quinone] Inhibitor N... 4 4
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 2 3
Sodium-dependent serotonin transporter Inhibitor 4-furan-2-yl-... 2 10
Reverse transcriptase Inhibitor Atevirdine Family 4 55
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 17 49
Sodium channel protein type 5 subunit alpha Ligand Enecadin Fa... 1 11
Metabotropic glutamate receptor 5 Ligand 3-methoxy-n-(6-methyl... 3 15
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor SK&F-96... 5 83
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 6 35
Tyrosine-protein kinase JAK3 and Tyrosine-protein kinase JAK2 ... 1 11
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 3 13
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 8 1
Mitogen-activated protein kinase 14 inhibitor N-(4-aminobutyl)... 1 28
Thymidylate synthase inhibitor (2R)-2-[[(4S)-4-carboxy-4-[[4-[... 55 43
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 2 3
Bifunctional dihydrofolate reductase-thymidylate synthase inhi... 5 45
Cathepsin S and Cathepsin K inhibitor AGN-PC-088VBO family 3 11
Adenosine kinase inhibitor 5-[3-(4-methoxyphenyl)propyl]-6-[2-... 2 11
Angiopoietin-1 receptor and Aurora kinase B ligand SureCN12658... 3 19
Thymidylate synthase inhibitor AC1LAB7Z family 8 3
Survival motor neuron protein inhibitor CHEMBL1307497 family 1 2
Thyroid hormone receptor beta and Ferritin light chain ligand ... 3 10
Cellular tumor antigen p53 and Microtubule-associated protein ... 1 4
Prostaglandin D2 receptor ligand 3-[2-methoxy-6-[2-(4-methoxyp... 2 12
Prelamin-A/C and Nuclear receptor ROR-gamma ligand CHEMBL13704... 1 7
Prelamin-A/C inhibitor CHEMBL1395532 family 1 10
Thyroid hormone receptor beta and Ferritin light chain ligand ... 1 35
Alpha-1D adrenergic receptor and Alpha-1B adrenergic receptor ... 6 9
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 6 13
Methionine--tRNA ligase inhibitor 2-[3-[(2-ethoxy-5-iodo-3-met... 9 32
Methionine--tRNA ligase inhibitor 2-[3-[(5-bromo-2-ethoxy-3-me... 9 11
Melanocortin receptor 4 ligand AGN-PC-076AML family 3 24
cAMP-specific 3',5'-cyclic phosphodiesterase 4A inhibitor Sure... 14 8
Equilibrative nucleoside transporter 1 inhibitor SureCN9046933... 2 9
Prostaglandin D2 receptor ligand 2-[3-[6-[2-(2,4-dichloropheny... 7 2
Prostaglandin D2 receptor ligand 2-[3-[2-methoxy-6-[2-(4-metho... 4 12
Prostaglandin D2 receptor ligand 2-methoxy-N-[2-(4-methoxyphen... 2 5
Prostaglandin D2 receptor ligand 2-methoxy-N-[2-(4-methoxyphen... 2 2
Prostaglandin D2 receptor ligand 2-methoxy-N-[2-(4-methoxyphen... 3 21
Adenosine receptor A3 ligand AGN-PC-08WSLM family 5 22
Adenosine receptor A1 and Adenosine receptor A3 ligand AGN-PC-... 6 8
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 2
Calcium/calmodulin-dependent protein kinase kinase 2 and Focal... 3 17
Integrin beta-1 and Integrin alpha-4 inhibitor SureCN2059024 f... 6 3
Cholecystokinin receptor type A ligand AGN-PC-0A9ULH family 8 8
Serine/threonine-protein kinase PLK1 inhibitor AGN-PC-0A9RFQ f... 2 1
Alpha-1D adrenergic receptor and Alpha-1B adrenergic receptor ... 1 0
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 9 10
Dihydrofolate reductase inhibitor 3-(2,4-diamino-6-methylquina... 2 1
Dihydrofolate reductase inhibitor 7-(2-ethoxynaphthalen-1-yl)-... 3 2
Melanin-concentrating hormone receptor 1 ligand N-[3-(2-aminoq... 4 1
Histamine H4 receptor and Histamine H3 receptor ligand 7-(fura... 2 2
Cathepsin S and Cathepsin L1 inhibitor arylaminoethyl amide, 1... 1 0
Rho-associated protein kinase 1 and cAMP-dependent protein kin... 1 11
Melanin-concentrating hormone receptor 1 ligand (E)-N-[2-[4-(1... 1 1
Integrin beta-1 and Integrin alpha-5 inhibitor (2S)-2-[(4-fluo... 7 1
Vascular endothelial growth factor receptor 2 and Aurora kinas... 4 3
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 1 0
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 7 3
Smoothened homolog and Mitogen-activated protein kinase 14 inh... 7 11
Epidermal growth factor receptor ligand SureCN4454332 family 18 5
Melanin-concentrating hormone receptor 1 ligand 3-[6-[3-(dimet... 14 6
Scavenger receptor class B member 1 ligand 5-[9-[3-(4,6-dimeth... 7 3
5-hydroxytryptamine receptor 1D ligand N-[4-[[5-[3-[2-(dimethy... 4 16
Angiopoietin-1 receptor and Vascular endothelial growth factor... 4 8
Nitric oxide synthase, inducible inhibitor 2-[1-(2-imidazol-1-... 4 3
Glycogen synthase kinase-3 beta and Casein kinase I isoform ga... 3 0
Angiopoietin-1 receptor and Vascular endothelial growth factor... 4 6
Tyrosine-protein kinase Lck inhibitor 3-[[4-(1,2-benzoxazol-3-... 2 0
Receptor tyrosine-protein kinase erbB-2 ligand SureCN4461871 f... 2 2
Xanthine dehydrogenase/oxidase inhibitor 5-(2-amino-4-oxo-1H-p... 8 30
Adenosine receptor A2a and Cytochrome P450 3A4 ligand N-[6-(3,... 5 2
G-protein coupled bile acid receptor 1 ligand 2-ethyl-6-[3-[4-... 4 6
Tyrosine-protein kinase ABL1 and Breakpoint cluster region pro... 8 5
Aurora kinase B and Aurora kinase A inhibitor 2-fluoro-6-metho... 2 0
Angiopoietin-1 receptor ligand SureCN1939461 family 1 0
Renin and Cytochrome P450 3A4 inhibitor AGN-PC-046RG9 family 8 28
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 2
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[2-(die... 12 2
Tyrosine-protein kinase JAK2 inhibitor 4-[[8-(4-methoxyphenyl)... 2 1
Focal adhesion kinase 1 inhibitor 2-[[2-(2-methoxy-4-morpholin... 2 1
Angiopoietin-1 receptor and Vascular endothelial growth factor... 5 0
Ephrin type-A receptor 3 and Tyrosine-protein kinase Fgr ligan... 1 3
Adenosine receptor A1 and Adenosine receptor A2a ligand N-[4-(... 4 0
Vascular endothelial growth factor receptor 2 ligand N-(4-chlo... 4 4
Bifunctional dihydrofolate reductase-thymidylate synthase inhi... 2 6
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 8 13
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 6 0
Adenosine receptor A1 and Adenosine receptor A2a ligand 7-meth... 2 0
5-hydroxytryptamine receptor 6 ligand 2-[(2Z)-2-[3-[(3-methoxy... 1 11
Nuclear receptor ROR-gamma and Prelamin-A/C ligand ST50133141 ... 1 0
Tyrosine-protein kinase Lck inhibitor SureCN374434 family 1 1
Tyrosine-protein kinase Lck and Mitogen-activated protein kina... 2 0
Insulin-like growth factor 1 receptor ligand SureCN311483 family 3 0
Histone deacetylase 1 inhibitor (7S)-N-hydroxy-7-[[2-(5-methox... 1 2
Rho-associated protein kinase 2 inhibitor AGN-PC-078WHL family 3 1
Transient receptor potential cation channel subfamily V member... 2 0
Adenosine receptor A2a ligand AGN-PC-077RYH family 16 5
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 3 1
Acyl-CoA desaturase inhibitor SureCN1182546 family 2 5
Inositol monophosphatase 1 and Prelamin-A/C inhibitor GNF-Pf-3... 1 5
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 7 6
Dual specificity protein kinase CLK4 and Dual specificity tyro... 6 2
Dual specificity protein kinase CLK4 and Dual specificity prot... 3 6
Serine/threonine-protein kinase pim-1 inhibitor PIM-1 INHIBITO... 1 0
Potassium-transporting ATPase subunit beta and Potassium-trans... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00377434 CHEMBL1644235 Bioactive 2-methoxy-N-[2-(4-methoxyphenyl)ethyl]-6-[3-(3-methyl-1,2,4-oxadiazol-5-yl)phenyl]pyrimidin-4-amine
CFAMM00377433 CHEMBL1644233 Bioactive 2-methoxy-N-[2-(4-methoxyphenyl)ethyl]-6-[3-(3-methyl-1,2-oxazol-5-yl)phenyl]pyrimidin-4-amine
CFAMM00377449 CHEMBL1644255 Bioactive 4-[2-methoxy-6-[2-(4-methoxyphenyl)ethylamino]pyrimidin-4-yl]benzamide
CFAMM00377432 CHEMBL1644232 Bioactive 1-[3-[2-methoxy-6-[2-(4-methoxyphenyl)ethylamino]pyrimidin-4-yl]phenyl]ethanone
CFAMM00377448 CHEMBL1644254 Bioactive 1-[4-[2-methoxy-6-[2-(4-methoxyphenyl)ethylamino]pyrimidin-4-yl]phenyl]ethanone
CFAMM00377446 CHEMBL1644247 Bioactive 2-fluoro-5-[2-methoxy-6-[2-(4-methoxyphenyl)ethylamino]pyrimidin-4-yl]benzoic acid

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26229 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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