CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM7136
Family Name Prostaglandin D2 receptor ligand 2-methoxy-N-[2-(4-methoxyphenyl)ethyl]-6-(1,3-oxazol-5-yl)pyrimidin-4-amine family
No. of Seeds 2 No. of Other Members 2
Family Centroid CFAMM00377456 Functional Category Bioactive
Superfamily Integrin beta-1 and Integrin alpha-4 Binder Superfamily 7
Class Class 850

Cousin Family NamesSeedsMembers
Epidermal growth factor receptor and Receptor tyrosine-protein... 3 140
Gamma-secretase subunit APH-1B Inhibitor E2012 Family 3 67
Metabotropic glutamate receptor 1 Ligand PF-1913539 Family 130 817
Adenosine receptor A2a Ligand BIIB014 Family 26 92
Serine/threonine-protein kinase mTOR Inhibitor INK128 Family 2 15
MK-3328 family 2 32
Smoothened homolog Inhibitor LDE225 Family 3 76
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 11 10
Peroxisome proliferator-activated receptor gamma and Peroxisom... 15 94
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 7 37
Fatty-acid amide hydrolase 1 Inhibitor 1-(oxazolo[4,5-b]pyridi... 19 34
Vascular endothelial growth factor receptor 1 and Vascular end... 4 44
Peptidyl-prolyl cis-trans isomerase A Inhibitor 3-[3-(3-benzyl... 3 34
Adenosine receptor A1 and Adenosine receptor A2a Ligand 4-(fur... 7 15
Adenosine receptor A1 and Adenosine receptor A2a Ligand N-(2-(... 21 108
Sodium-dependent serotonin transporter Inhibitor 4-furan-2-yl-... 2 10
Reverse transcriptase Inhibitor Atevirdine Family 4 55
Arachidonate 5-lipoxygenase Inhibitor 5-methyl-n-phenylbenzo[d... 5 13
Peroxisome proliferator-activated receptor delta ligand SureCN... 8 19
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK1 ... 5 25
Tyrosine-protein kinase JAK3 and Tyrosine-protein kinase JAK2 ... 1 11
Adenosine receptor A2b and Adenosine receptor A1 ligand SureCN... 1 0
Somatostatin receptor type 5 and Potassium voltage-gated chann... 2 21
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 9 3
Inosine-5'-monophosphate dehydrogenase 2 inhibitor [2-[N-methy... 1 18
Collagenase 3 inhibitor N-[[3-[5-[[(1R)-1-cyclohexyl-2-(methyl... 6 9
Angiopoietin-1 receptor and Aurora kinase B ligand SureCN12658... 3 19
Prelamin-A/C inhibitor CHEMBL1374443 family 1 6
Ferritin light chain and Ras-related protein Rab-9A inhibitor ... 1 11
Neuropeptide Y receptor type 5 ligand SureCN5771669 family 2 3
Thyroid hormone receptor beta and Ferritin light chain ligand ... 1 35
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 2 1
Equilibrative nucleoside transporter 1 inhibitor SureCN9046933... 2 9
Prostaglandin D2 receptor ligand 1-[3-[2-methoxy-6-[2-(4-metho... 6 16
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 5 8
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 2
Adenosine receptor A2b and Adenosine receptor A2a ligand AGN-P... 2 0
Proto-oncogene tyrosine-protein kinase Src and Vascular endoth... 3 1
Adenosine receptor A2a ligand 2-(furan-2-yl)-7-[3-[(4-phenylpi... 11 2
Fatty-acid amide hydrolase 1 inhibitor 3-[(3R)-1-[4-(1-benzofu... 4 4
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-09ODY0 ... 2 5
Cannabinoid receptor 2 ligand [4-(5-tert-butyl-1,3-benzoxazol-... 4 1
Fatty-acid amide hydrolase 1 inhibitor 2-(1,3-dihydroisoindol-... 2 3
Glycogen synthase kinase-3 beta and Cyclin-dependent kinase 2 ... 2 3
Histamine H4 receptor and Histamine H3 receptor ligand 7-(fura... 2 2
Histamine H3 receptor ligand 2-(4-piperidin-1-ylpiperidin-1-yl... 1 3
MAP kinase-activated protein kinase 2 inhibitor 4-[5-[4-(4-pip... 1 11
Tubulin beta-4A chain and Tubulin beta-2B chain inhibitor N-(2... 1 4
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 7 3
Dipeptidyl peptidase 4 inhibitor [(2S,4S)-4-[4-(1,3-benzoxazol... 3 4
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 3 0
Tyrosine-protein kinase SYK inhibitor 4-[[3-[8-[(5,6-dimethoxy... 2 0
Scavenger receptor class B member 1 ligand 2-[9-[3-(4,6-dimeth... 1 0
Glycogen synthase kinase-3 beta and Casein kinase I isoform ga... 3 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 1 2
Peroxisome proliferator-activated receptor gamma and Peroxisom... 3 0
Receptor tyrosine-protein kinase erbB-2 ligand SureCN4461871 f... 2 2
Prostaglandin E synthase inhibitor 1-[5-chloro-6-(4-fluorophen... 8 27
Adenosine receptor A2a and Cytochrome P450 3A4 ligand N-[6-(3,... 5 2
G-protein coupled bile acid receptor 1 ligand 2-ethyl-6-[3-[4-... 4 6
Tyrosine-protein kinase ABL1 and Breakpoint cluster region pro... 8 5
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[2-(die... 12 2
Angiopoietin-1 receptor and Vascular endothelial growth factor... 5 0
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 29 1
Adenosine receptor A2a and Adenosine receptor A1 ligand 1-[(2-... 2 0
Mitogen-activated protein kinase 14 inhibitor 4-[4-(4-fluoroph... 1 5
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 6
Adenosine kinase inhibitor AGN-PC-0757MS family 2 0
RAF proto-oncogene serine/threonine-protein kinase inhibitor a... 8 6
Insulin-like growth factor 1 receptor ligand SureCN311483 family 3 0
Rho-associated protein kinase 2 inhibitor SureCN3232097 family 1 1
C-C chemokine receptor type 3 ligand SureCN6338683 family 1 2
Receptor tyrosine-protein kinase erbB-2 ligand AGN-PC-03J2ZU f... 1 2
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 2 2
Adenosine receptor A2a and Adenosine receptor A1 ligand SureCN... 19 2
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 7 6
Poly [ADP-ribose] polymerase 1 inhibitor AGN-PC-077D0D family 3 0
Adenosine receptor A2a and Adenosine receptor A1 ligand triazi... 3 0
Adenosine receptor A2a and Adenosine receptor A1 ligand SureCN... 9 0
Neuronal acetylcholine receptor subunit alpha-7 and 5-hydroxyt... 1 0
Dual specificity protein kinase CLK4 and Dual specificity tyro... 6 2
Dual specificity protein kinase CLK4 and Dual specificity prot... 3 6
Cholesteryl ester transfer protein inhibitor AGN-PC-09QM3I family 1 9
Diacylglycerol O-acyltransferase 1 inhibitor SureCN2789698 family 2 8
Inosine-5'-monophosphate dehydrogenase 2 inhibitor SureCN72661... 3 3
Histamine H3 receptor ligand 9-[2-(4-piperidin-1-ylpiperidin-1... 1 3
Somatostatin receptor type 5 ligand SureCN3572493 family 1 3
Inosine-5'-monophosphate dehydrogenase 2 inhibitor AC1LAY14 fa... 2 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00377457 CHEMBL1644256 Bioactive 2-methoxy-N-[2-(4-methoxyphenyl)ethyl]-6-[3-(1,3-oxazol-5-yl)phenyl]pyrimidin-4-amine
CFAMM00377456 CHEMBL1644234 Bioactive 2-methoxy-N-[2-(4-methoxyphenyl)ethyl]-6-(1,3-oxazol-5-yl)pyrimidin-4-amine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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