CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM7137
Family Name Prostaglandin D2 receptor ligand 2-methoxy-N-[2-(4-methoxyphenyl)ethyl]-6-(5-methylthiophen-2-yl)pyrimidin-4-amine family
No. of Seeds 3 No. of Other Members 21
Family Centroid CFAMM00377479 Functional Category Bioactive
Superfamily Aurora kinase A and Prelamin-A/C Binder Superfamily
Class Class 1249

Cousin Family NamesSeedsMembers
Epidermal growth factor receptor Ligand Gefitinib Family 26 600
Corticotropin-releasing factor receptor 1 Ligand CRF-1 Antagon... 29 421
Receptor tyrosine-protein kinase erbB-2 Inhibitor CP-724714 Fa... 4 180
SB1518 family 7 103
Tyrosine kinase Inhibitor PKI166 Family 17 198
Angiopoietin-1 receptor and Tyrosine-protein kinase Lck Inhibi... 3 64
Fatty-acid amide hydrolase 1 Inhibitor BMS-1 Family 5 22
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 17 49
Sodium channel protein type 5 subunit alpha Ligand Enecadin Fa... 1 11
Rho-associated protein kinase 2 inhibitor SureCN13457044 family 1 17
Rho-associated protein kinase 1 inhibitor AGN-PC-04T4AX family 1 6
Bifunctional dihydrofolate reductase-thymidylate synthase inhi... 5 45
Aurora kinase A inhibitor AGN-PC-00BCUF family 16 43
Survival motor neuron protein inhibitor CHEMBL1307497 family 1 2
Prostaglandin D2 receptor ligand 3-[2-methoxy-6-[2-(4-methoxyp... 2 12
Prelamin-A/C and Nuclear receptor ROR-gamma ligand CHEMBL13704... 1 7
Inositol monophosphatase 1 and Microtubule-associated protein ... 1 12
Dual specificity protein kinase CLK4 and Dual specificity tyro... 1 14
Adenosine kinase inhibitor SureCN8134468 family 3 7
Methionine--tRNA ligase inhibitor 2-[3-[(2-ethoxy-5-iodo-3-met... 9 32
Prostaglandin D2 receptor ligand 2-[3-[2-methoxy-6-[2-(4-metho... 4 12
Prostaglandin D2 receptor ligand 2-methoxy-N-[2-(4-methoxyphen... 2 5
Prostaglandin D2 receptor ligand 1-[3-[2-methoxy-6-[2-(4-metho... 6 16
Prostaglandin D2 receptor ligand 2-methoxy-N-[2-(4-methoxyphen... 1 14
Adenosine receptor A3 ligand AGN-PC-08WSLM family 5 22
Adenosine receptor A1 and Adenosine receptor A3 ligand AGN-PC-... 6 8
cAMP-specific 3',5'-cyclic phosphodiesterase 4B and cAMP-speci... 1 9
Mu-type opioid receptor and Nitric oxide synthase, brain ligan... 3 0
Arachidonate 15-lipoxygenase inhibitor SureCN14288120 family 3 12
Serine/threonine-protein kinase Chk1 inhibitor 2-(5-methoxy-3-... 4 5
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 2
Tyrosine-protein kinase ITK/TSK and Tyrosine-protein kinase Lc... 2 6
Melanin-concentrating hormone receptor 1 ligand (1S,3S)-1-N-(4... 3 9
Adenosine receptor A2a and Adenosine receptor A1 ligand N-[2-(... 5 6
Adenosine receptor A2a and Adenosine receptor A1 ligand 2-(3-c... 3 3
Bifunctional dihydrofolate reductase-thymidylate synthase inhi... 2 6
Adenosine receptor A2a ligand AGN-PC-077RYH family 16 5
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 1 0
Dual specificity protein kinase CLK4 and Dual specificity prot... 3 6
Urokinase-type plasminogen activator inhibitor AGN-PC-01XMBP f... 3 7
Beta-secretase 1 and Potassium voltage-gated channel subfamily... 1 0
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor 7-methy... 2 0
Epidermal growth factor receptor ligand AGN-PC-07C0GB family 1 0
Glucokinase inhibitor AGN-PC-03ZE4O family 4 5


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00377479 CHEMBL1644239 Bioactive 2-methoxy-N-[2-(4-methoxyphenyl)ethyl]-6-(5-methylthiophen-2-yl)pyrimidin-4-amine
CFAMM00377470 CHEMBL1644261 Bioactive 6-(1-benzothiophen-2-yl)-2-methoxy-N-[2-(4-methoxyphenyl)ethyl]pyrimidin-4-amine
CFAMM00377469 CHEMBL1644240 Bioactive 1-[5-[2-methoxy-6-[2-(4-methoxyphenyl)ethylamino]pyrimidin-4-yl]thiophen-2-yl]ethanone

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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