CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM7139
Family Name Butyrylcholinesterase and Acetylcholinesterase inhibitor AGN-PC-093IT9 family
No. of Seeds 9 No. of Other Members 24
Family Centroid CFAMM00377511 Functional Category Bioactive with Natural Product
Superfamily Acetylcholinesterase and Butyrylcholinesterase Binder Superfamily 2
Class Class 24

Cousin Family NamesSeedsMembers
Beta adrenergic receptor ligand monosubstituted indole derivat... 14 475
DNA Binder Primaquine Family 3 245
Melatonin receptor type 1A Ligand Melatonin Family 20 988
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor indole... 28 2712
Peptide deformylase, mitochondrial Inhibitor Trimetrexate Family 4 311
Phospholipase A2 Inhibitor Quinacrine Family 13 95
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741
Na+-K+-ATPase transmembrane protein Inhibitor Sanguinarine Family 8 20
Amyloid beta A4 protein Inhibitor Florbetapir F-18 Family 8 265
Hepatocyte growth factor receptor and Vascular endothelial gro... 28 178
Abelson tyrosine-protein kinase 2 and Proto-oncogene tyrosine-... 67 130
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 11 49
Nicotinic acetylcholine receptor alpha2 / alpha3 Ligand Ibogai... 3 21
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
von Willebrand factor Inhibitor Auryntricarboxylic Acid (ata) ... 12 81
Hemoglobin subunit alpha Inhibitor 2-[(2-methoxy-5-methylpheno... 5 48
Hemoglobin subunit alpha Inhibitor 4-[(5-methoxy-2-methylpheno... 3 12
Platelet-derived growth factor receptor alpha and Platelet-der... 2 9
Platelet-derived growth factor receptor beta and Epidermal gro... 3 7
Oestrogen receptor and Estrogen receptor beta Ligand Pipendoxi... 11 48
Alpha-1A adrenergic receptor Ligand RS-17053 Family 9 6
Melanin-concentrating hormone receptor 1 Ligand 8-sec-butoxy-q... 30 39
5-hydroxytryptamine receptor 2A and Alpha-2A adrenergic recept... 4 29
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 17 49
Arachidonate 5-lipoxygenase Inhibitor TZI-41127 Family 7 34
Metabotropic glutamate receptor 5 Ligand 3-methoxy-5-(1,5-naph... 4 20
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 17 69
Histamine H3 receptor and Potassium voltage-gated channel subf... 1 0
5-hydroxytryptamine receptor 1A ligand (2S)-1-[(3S,4R)-3-(1,3-... 2 0
Muscarinic acetylcholine receptor M2 and Acetylcholinesterase ... 4 24
Acetylcholinesterase and Muscarinic acetylcholine receptor M2 ... 2 7
cAMP-specific 3',5'-cyclic phosphodiesterase 4D and cAMP-speci... 3 1
Cannabinoid receptor 1 ligand AGN-PC-088XYA family 4 6
Melanin-concentrating hormone receptor 1 and Cytochrome P450 3... 8 2
Proto-oncogene tyrosine-protein kinase Src inhibitor SureCN525... 8 8
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 8 12
Prelamin-A/C inhibitor 1-[(3,4-dimethoxyphenethyl)amino]-3-(1H... 1 2
Hypoxia-inducible factor 1-alpha and Lethal factor inhibitor C... 1 1
Leukotriene B4 receptor 1 ligand SureCN8987047 family 4 3
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor 3-(1,3-... 2 9
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 7 4
Proto-oncogene tyrosine-protein kinase Src inhibitor AC1NS5MA ... 3 4
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-09Q7W... 7 3
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 27
Sodium-dependent serotonin transporter inhibitor (4S)-4-[4-[(2... 1 3
Melanin-concentrating hormone receptor 1 ligand AGN-PC-075FPC ... 6 1
Melanin-concentrating hormone receptor 1 ligand AGN-PC-075FSU ... 1 1
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 3 0
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 2
Corticotropin-releasing factor receptor 1 ligand 2-(2-ethyl-4,... 4 9
Vascular endothelial growth factor receptor 2 and Vascular end... 2 52
Cholinesterase and Acetylcholinesterase inhibitor 5-hydroxy-7-... 5 19
Melanin-concentrating hormone receptor 1 and Potassium voltage... 1 2
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 4 5
Acetylcholinesterase and Butyrylcholinesterase inhibitor (E)-3... 4 5
Cholinesterase and Acetylcholinesterase inhibitor tacrine deri... 10 0
Cholinesterase and Acetylcholinesterase inhibitor 6-[2-methoxy... 12 6
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 6 4
Cholinesterase and Acetylcholinesterase inhibitor 6-[4-[2-fluo... 17 0
Estrogen receptor and Estrogen receptor beta ligand N-[(2R)-4-... 7 11
C5a anaphylatoxin chemotactic receptor 1 ligand 2-(2,6-diethyl... 3 5
D(1A) dopamine receptor and D(2) dopamine receptor ligand (6aR... 3 6
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 2 4
Matrix metalloproteinase-9 and Neutrophil collagenase inhibito... 3 7
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 3 2
5-hydroxytryptamine receptor 6 ligand AGN-PC-075BWR family 1 1
Substance-P receptor ligand AGN-PC-0D60L0 family 2 7
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-077PJ... 4 4
Adenosine receptor A1 ligand BAS 00727702 family 1 4
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 1 1
Sodium-dependent serotonin transporter and D(2) dopamine recep... 4 0
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 1 1
Dipeptidyl peptidase 4 inhibitor 2-[3-(aminomethyl)-4-(4-fluor... 3 0
Corticotropin-releasing factor receptor 1 ligand 2-[2,6-dimeth... 10 10
Small conductance calcium-activated potassium channel protein ... 2 2
Carbonic anhydrase 12 and Carbonic anhydrase 9 inhibitor 4-[4-... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00377512 CHEMBL1644286 Bioactive AGN-PC-093IT8
CFAMM00377518 CHEMBL1644291 Bioactive AGN-PC-09QGJE
CFAMM00377511 CHEMBL1644288 Bioactive AGN-PC-093IT9
CFAMM00377517 CHEMBL1644290 Bioactive AGN-PC-09QLRN
CFAMM00377510 CHEMBL1644289 Bioactive AGN-PC-09QK14
CFAMM00377516 CHEMBL1783241 Bioactive AGN-PC-09Q80K
CFAMM00377508 CHEMBL1783237 Bioactive AGN-PC-09Q7WB

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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