CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM714
Family Name 5-hydroxytryptamine receptor 1A and D(1A) dopamine receptor ligand AGN-PC-07ZFOD family
No. of Seeds 2 No. of Other Members 3
Family Centroid CFAMM00314539 Functional Category Bioactive
Superfamily Histamine H1 receptor ligand tricyclic antidepressant Superfamily
Class Class 88

Cousin Family NamesSeedsMembers
Glutamate dehydrogenase inhibitor quinoline derivative Chloroq... 7 189
Histamine H1 receptor ligand tricyclic antidepressant Deslorat... 6 136
Histamine H1 receptor Ligand Triprolidine Family 19 316
Sarcoplasmic/endoplasmic reticulum calcium ATPase inhibitor qu... 2 60
Transient receptor potential cation channel subfamily V member... 16 295
Cannabinoid receptor 1 Ligand AZD2207 Family 18 48
Reverse transcriptase Inhibitor Dapivirine Family 5 72
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 23 63
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 35 270
ABC294640 family 5 75
Nicotinic acetylcholine receptor Ligand Epibatidine Family 36 19
D(4) dopamine receptor Ligand L-745,870 Family 30 205
Beta-secretase 1 Inhibitor N~3~-(3-pyridin-3-ylbenzyl)pyridine... 31 66
D(2) dopamine receptor and D(3) dopamine receptor Ligand 4-(4-... 6 48
Epidermal growth factor receptor Ligand PD-158780 Family 98 89
5-hydroxytryptamine receptor 2A Ligand 8-chloro-1,2,3,4-tetrah... 5 4
Cyclin-dependent kinase 1 Inhibitor CGP-60474 Family 14 103
Acetylcholinesterase and Cholinesterase Inhibitor Huprine-tacr... 43 17
Adenosine receptor A3 Ligand 2-(5-chloro-1h-benzo[d]imidazol-2... 7 51
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 13 26
Proto-oncogene tyrosine-protein kinase Src Inhibitor BMS-27970... 41 59
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Glycogen synthase kinase-3 beta Inhibitor CHIR-98023 Family 5 6
Bifunctional epoxide hydrolase 2 Inhibitor 6-amino-n-(2,4-dich... 10 116
Protein kinase C theta type Inhibitor 4-(3h-indol-4-ylamino)-5... 2 2
Macrophage migration inhibitory factor Inhibitor 1-(2-chloroph... 2 22
Cytochrome P450 11B1, mitochondrial Inhibitor 2-methyl-1,2-di-... 8 15
Sodium-dependent serotonin transporter Inhibitor 6-chloro-2-pi... 5 35
Metabotropic glutamate receptor 5 Ligand 5-((6-methylpyridin-2... 14 22
Acetylcholinesterase and Cholinesterase Inhibitor Huprine-tacr... 62 27
Choline kinase alpha Inhibitor Bisquinolinium Derivative Family 10 7
Leukocyte tyrosine kinase receptor and ALK tyrosine kinase rec... 3 0
Adenosine kinase inhibitor 5-(4-chlorophenyl)-6-[2-(6-morpholi... 8 8
D(2) dopamine receptor and D(3) dopamine receptor ligand AGN-P... 1 0
Epidermal growth factor receptor ligand N-[4-(3-chloro-4-fluor... 8 4
Prothrombin and Trypsin-1 inhibitor SureCN12636557 family 9 1
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 5 0
Acetylcholine receptor subunit delta ligand Guanidine, N-[(6-c... 2 15
Acetylcholine receptor subunit delta and Neuronal acetylcholin... 3 5
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 3 7
Mitogen-activated protein kinase 14 inhibitor 4-(2-chloropheny... 4 0
Epidermal growth factor receptor and Receptor tyrosine-protein... 8 4
Neuronal acetylcholine receptor subunit beta-2 and Neuronal ac... 8 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 7 4
Adenosine kinase inhibitor 4-[2-[5-(4-chlorophenyl)-6-piperazi... 3 1
D(4) dopamine receptor and D(3) dopamine receptor ligand 1-(2,... 1 0
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 3 1
Nociceptin receptor and Potassium voltage-gated channel subfam... 5 2
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 2 1
Neuronal acetylcholine receptor subunit beta-2 and Neuronal ac... 2 1
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 2 5
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 10 1
Neuropeptide Y receptor type 5 ligand SureCN4464548 family 17 2
Nociceptin receptor and Mu-type opioid receptor ligand N-[(1R,... 4 2
Cannabinoid receptor 1 ligand AGN-PC-077JWI family 7 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00314540 CHEMBL1927094 Bioactive N'-[3-[4-(3-chlorophenyl)piperazin-1-yl]propyl]-N-cyanopyridine-2-carboximidamide
CFAMM00314539 CHEMBL1086958 Bioactive AGN-PC-07ZFOD

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26233 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543