CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM7145
Family Name Potassium voltage-gated channel subfamily H member 2 and Sodium-dependent noradrenaline transporter ligand SureCN1029616 family
No. of Seeds 2 No. of Other Members 13
Family Centroid CFAMM00377557 Functional Category Bioactive
Superfamily Corticotropin-releasing factor receptor 1 Ligand Cp-316,311 Superfamily
Class Class 1076

Cousin Family NamesSeedsMembers
Beta adrenergic receptor ligand monosubstituted indole derivat... 14 475
Melatonin receptor type 1A Ligand Melatonin Family 20 988
Sodium channel protein type 5 subunit alpha Ligand Dibucaine F... 2 136
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor indole... 28 2712
Phospholipase A2 Inhibitor Quinacrine Family 13 95
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741
Amyloid beta A4 protein Inhibitor Florbetapir F-18 Family 8 265
Nicotinic acetylcholine receptor Ligand AZD0328 Family 11 97
Corticotropin-releasing factor receptor 1 Ligand Cp-316,311 Fa... 5 74
5-hydroxytryptamine receptor 1A and D(3) dopamine receptor Lig... 9 115
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 11 49
Grt 6005/06 family 4 22
Nicotinic acetylcholine receptor alpha2 / alpha3 Ligand Ibogai... 3 21
Nicotinic acetylcholine receptor Ligand Dianicline Family 6 13
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 37 265
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
von Willebrand factor Inhibitor Auryntricarboxylic Acid (ata) ... 12 81
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 13 22
Hemoglobin subunit alpha Inhibitor 2-[(2-methoxy-5-methylpheno... 5 48
Platelet-derived growth factor receptor alpha and Platelet-der... 2 14
Oestrogen receptor and Estrogen receptor beta Ligand Pipendoxi... 11 48
Alpha-1A adrenergic receptor Ligand RS-17053 Family 9 6
D(2) dopamine receptor Ligand SLV-314 Family 19 69
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 4 35
RAC-gamma serine/threonine-protein kinase Inhibitor A-443654 F... 67 59
Neuromedin-K receptor Ligand 3-methoxy-n',2-diphenylquinoline-... 14 33
Squalene synthase Inhibitor ER-119884 Family 2 3
5-hydroxytryptamine receptor 2A and Amine oxidase [flavin-cont... 4 32
5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine ... 3 24
5-hydroxytryptamine receptor 2A and Alpha-2A adrenergic recept... 4 29
Arachidonate 5-lipoxygenase Inhibitor TZI-41127 Family 7 34
Metabotropic glutamate receptor 5 Ligand 3-methoxy-5-(2-methyl... 7 27
Metabotropic glutamate receptor 5 Ligand 3-methoxy-5-(1,5-naph... 4 20
Metabotropic glutamate receptor 5 Ligand 7-(3,5-dimethoxypheny... 2 7
Cannabinoid receptor 1 Ligand 1-(2-morpholinoethyl)-1h-indol-3... 8 46
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 3 16
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 17 69
Histamine H3 receptor and Potassium voltage-gated channel subf... 1 2
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 10 4
Corticotropin-releasing factor receptor 1 ligand AGN-PC-074YQD... 1 5
Neuropeptide Y receptor type 1 ligand SureCN7959923 family 1 6
Bloom syndrome protein and Prelamin-A/C inhibitor Dubinidine f... 1 17
Histamine H3 receptor and Cytochrome P450 2D6 ligand AGN-PC-00... 18 32
Potassium voltage-gated channel subfamily H member 2 and Kappa... 5 33
Histamine H3 receptor ligand AGN-PC-00BG7Z family 11 49
Disintegrin and metalloproteinase domain-containing protein 17... 2 1
Hypoxia-inducible factor 1-alpha and Lethal factor inhibitor C... 1 1
Leukotriene B4 receptor 1 ligand SureCN8987110 family 8 20
D(4) dopamine receptor and D(2) dopamine receptor ligand 1-(2-... 3 3
Coagulation factor X and Anionic trypsin-2 inhibitor AGN-PC-07... 1 1
Glucagon receptor and Mitogen-activated protein kinase 14 liga... 6 5
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 8 8
Coagulation factor X and Prothrombin inhibitor AGN-PC-0759SH f... 5 4
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 2 0
Somatostatin receptor type 2 ligand SureCN4313450 family 2 25
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-09Q7W... 7 3
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 1
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 16 19
Muscarinic acetylcholine receptor M3 ligand 3-fluoro-2-(3-pipe... 3 1
Cysteinyl leukotriene receptor 1 ligand SureCN7008285 family 12 97
Sodium-dependent serotonin transporter inhibitor SureCN7536104... 6 2
Sodium-dependent serotonin transporter inhibitor AGN-PC-075G9A... 3 2
Disintegrin and metalloproteinase domain-containing protein 17... 13 3
Disintegrin and metalloproteinase domain-containing protein 17... 16 2
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 4 5
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 5 14
Potassium voltage-gated channel subfamily H member 2 and 5-hyd... 2 2
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 6 4
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 4 4
Histamine H3 receptor and D(3) dopamine receptor ligand BODILI... 1 0
5-hydroxytryptamine receptor 6 ligand 2-methyl-5-(2-nitropheno... 1 6
Proto-oncogene tyrosine-protein kinase receptor Ret and Vascul... 5 14
Histamine H3 receptor and Sodium-dependent serotonin transport... 3 2
Potassium voltage-gated channel subfamily KQT member 2 ligand ... 3 4
C5a anaphylatoxin chemotactic receptor 1 ligand 2-(2,6-diethyl... 3 5
D(2) dopamine receptor ligand SureCN10575660 family 1 1
Sigma non-opioid intracellular receptor 1 ligand 1'-[4-[1-(4-f... 2 0
Prothrombin and Trypsin-1 inhibitor AGN-PC-074I4I family 3 1
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 3 2
Sodium-dependent dopamine transporter and Sodium-dependent ser... 2 0
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor 3-(2,3-... 2 0
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-077PJ... 4 4
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor CHEMBL4... 6 2
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 23 5
Protein kinase C theta type and Protein kinase C delta type in... 10 7
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 18 0
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 1 1
Lanosterol synthase inhibitor AGN-PC-07BZTX family 2 0
P2Y purinoceptor 12 inhibitor (4S)-4-[[4-[(1-acetylpiperidin-4... 58 15
Sodium-dependent serotonin transporter and D(2) dopamine recep... 4 0
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 1 1
Dipeptidyl peptidase 4 inhibitor 2-[3-(aminomethyl)-4-(4-fluor... 3 0
Metabotropic glutamate receptor 1 ligand (Z)-[(3-ethyl-2-metho... 1 4
Gamma-aminobutyric acid receptor subunit beta-3 and Gamma-amin... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00377565 CHEMBL1644609 Bioactive SureCN12955592
CFAMM00377557 CHEMBL1644470 Bioactive SureCN1029616

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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