| Cousin Family Names | Seeds | Members |
|---|
| Gamma-aminobutyric acid A receptor Ligand imidazopyridine deri... | 5 | 644 |
| 5-hydroxytryptamine receptor 1D Ligand Rizatriptan Family | 7 | 460 |
| Alpha-2 adrenergic receptor Ligand Dexmedetomidine Family | 32 | 639 |
| Benzodiazepine receptor Ligand Midazolam Family | 5 | 160 |
| Amiloride-sensitive sodium channel subunit alpha Ligand Triamt... | 8 | 98 |
| Histamine H1 receptor Ligand Mizolastine Family | 14 | 603 |
| Metabotropic glutamate receptor 5 Ligand ADX-48621 Family | 15 | 444 |
| C-X-C chemokine receptor type 4 Ligand AMD-070 Family | 12 | 800 |
| Transient receptor potential cation channel subfamily V member... | 16 | 295 |
| Transient receptor potential cation channel subfamily V member... | 15 | 457 |
| Vascular endothelial growth factor Inhibitor PTC299 Family | 6 | 145 |
| Cyclin-dependent kinase 2 Inhibitor Seliciclib Family | 29 | 292 |
| Farnesyltransferase beta subunit, putative Inhibitor Zarnestra... | 10 | 56 |
| Fibroblast growth factor receptor 2 and Fibroblast growth fact... | 11 | 86 |
| Cannabinoid receptor 1 Ligand CP-945598 Family | 18 | 173 |
| 5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... | 14 | 234 |
| Adenosine receptor A1 Ligand SLV320 Family | 6 | 79 |
| Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family | 53 | 580 |
| HCV NS4B protein Inhibitor Clemizole Family | 2 | 43 |
| Genomic RNA for RNA-dependent RNA polymerase gene (clone HCV-J... | 13 | 55 |
| RAC-gamma serine/threonine-protein kinase Inhibitor AZD5363 Fa... | 35 | 69 |
| PF-4217903 family | 14 | 65 |
| Tryptase Inhibitor Babim Family | 12 | 90 |
| Histamine H3 receptor and Histamine H4 receptor Ligand Clobenp... | 31 | 38 |
| D(4) dopamine receptor Ligand L-745,870 Family | 30 | 205 |
| Tyrosine kinase Inhibitor PKI166 Family | 17 | 198 |
| Prostaglandin G/H synthase 2 Inhibitor RWJ-67657 Family | 3 | 33 |
| Interleukin-1 receptor type 1 and Mitogen-activated protein ki... | 7 | 151 |
| Histamine H3 receptor Ligand SCH79687 Family | 11 | 29 |
| Beta-secretase 1 Inhibitor 6-[2-(1h-indol-6-yl)ethyl]pyridin-2... | 10 | 43 |
| Beta-secretase 1 Inhibitor N~3~-(3-pyridin-3-ylbenzyl)pyridine... | 31 | 66 |
| Adenosine receptor A1 and Adenosine receptor A2a Ligand 2,6-di... | 13 | 14 |
| Adenosine receptor A3 Ligand 2,6-bis(4-chlorophenyl)-9h-purine... | 4 | 12 |
| Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... | 18 | 109 |
| Cytochrome P450 11B1, mitochondrial Inhibitor 1-(4-cyanobenzyl... | 14 | 13 |
| Epidermal growth factor receptor Ligand PD-158780 Family | 98 | 89 |
| Adenosine receptor A2a and Adenosine receptor A3 Ligand 5-buty... | 3 | 18 |
| Cyclin-dependent kinase 4 Inhibitor 1-pyridin-2-yl-3-quinolin-... | 2 | 5 |
| Arachidonate 5-lipoxygenase Inhibitor 2,4,5-triarylimidazole A... | 3 | 16 |
| Methionine aminopeptidase 2 Inhibitor 2-(pyridin-2-yl)-1h-benz... | 6 | 19 |
| Epidermal growth factor receptor Ligand (3-bromo-phenyl)-quina... | 7 | 5 |
| Aromatase and Thromboxane-A synthase Inhibitor 6-(1h-imidazol-... | 3 | 8 |
| Metabotropic glutamate receptor 5 Ligand 3-(4-pyridin-2-yl-imi... | 6 | 5 |
| Adenosine receptor A3 Ligand 1-benzyl-1h-1,3,4b,9-tetraaza-flu... | 19 | 165 |
| Cyclin-dependent kinase 1 Inhibitor CGP-60474 Family | 14 | 103 |
| Adenosine receptor A1 Ligand Phenyl-(9-phenyl-9h-purin-6-yl)-a... | 7 | 12 |
| Mitogen-activated protein kinase 14 and Tyrosine-protein kinas... | 1 | 9 |
| Mitogen-activated protein kinase 3 and RAF proto-oncogene seri... | 8 | 5 |
| Alpha-1A adrenergic receptor Ligand A-315456 Family | 7 | 17 |
| RAC-gamma serine/threonine-protein kinase and Rho-associated p... | 16 | 46 |
| Adenosine receptor A3 and Dual specificity mitogen-activated p... | 5 | 27 |
| Adenosine receptor A3 Ligand 2-(5-chloro-1h-benzo[d]imidazol-2... | 7 | 51 |
| Adenosine receptor A3 Ligand 2-(4-nitro-1h-benzo[d]imidazol-2-... | 2 | 12 |
| Glycogen synthase kinase-3 beta and Mitogen-activated protein ... | 8 | 8 |
| Proto-oncogene tyrosine-protein kinase Src Inhibitor BMS-27970... | 41 | 59 |
| Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-phen... | 8 | 11 |
| Dipeptidyl peptidase 4 Inhibitor (5-phenyl-3h-benzo[d]imidazol... | 5 | 13 |
| Mitogen-activated protein kinase kinase kinase 8 and Stromelys... | 6 | 53 |
| Fatty-acid amide hydrolase 1 Inhibitor JNJ-1661010 Family | 3 | 14 |
| Indoleamine 2,3-dioxygenase 1 Inhibitor 3-(4h-imidazol-4-yl)be... | 6 | 3 |
| Aromatase and Cytochrome P450 26A1 Inhibitor Liarozole Family | 4 | 1 |
| RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... | 219 | 124 |
| Potassium voltage-gated channel subfamily H member 2 Ligand AZ... | 21 | 42 |
| Glycogen synthase kinase-3 beta Inhibitor CHIR-98023 Family | 5 | 6 |
| Glycogen synthase kinase-3 beta Inhibitor 4-(5-bromo-1h-indol-... | 7 | 18 |
| Cytochrome P450 11B1, mitochondrial Inhibitor 1-(4-bromobenzyl... | 3 | 0 |
| Histamine H3 receptor Ligand 4-(2-(phenylamino)ethyl)-1h-imida... | 5 | 16 |
| Gamma-aminobutyric acid receptor subunit alpha-1 Ligand N-(9h-... | 5 | 2 |
| Type-2 angiotensin II receptor Ligand L-158809 Family | 22 | 136 |
| Proto-oncogene tyrosine-protein kinase Src Inhibitor CGP-62464... | 3 | 10 |
| Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... | 6 | 55 |
| Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 3-chlo... | 3 | 2 |
| Sodium channel protein type 1 subunit alpha and Sodium channel... | 10 | 14 |
| Metabotropic glutamate receptor 5 Ligand 2-(3,5-dichlorophenyl... | 2 | 3 |
| Xanthine dehydrogenase/oxidase Inhibitor 3,5-di(pyridin-4-yl)-... | 6 | 3 |
| Melanocortin receptor Ligand Ac-his-dphe(3,4-dicl)-arg-trp-nh2... | 10 | 14 |
| Cytochrome P450 2D6 and Cytochrome P450 3A4 Inhibitor 2-(2-(4-... | 25 | 10 |
| Adenosine receptor A3 and Adenosine receptor A2a ligand 5-buty... | 3 | 13 |
| Prothrombin inhibitor SureCN5856722 family | 3 | 16 |
| Somatostatin receptor type 4 and Glucosylceramidase ligand MLS... | 1 | 16 |
| Neuronal acetylcholine receptor subunit alpha-7 and Potassium ... | 7 | 3 |
| Corticotropin-releasing factor receptor 1 ligand SureCN5395386... | 6 | 5 |
| cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... | 4 | 2 |
| Tyrosine-protein kinase JAK1 and Tyrosine-protein kinase JAK2 ... | 3 | 12 |
| Aurora kinase B inhibitor AGN-PC-07ZZ0Y family | 2 | 12 |
| Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn in... | 7 | 7 |
| Platelet-activating factor receptor ligand SureCN9383514 family | 4 | 1 |
| RAF proto-oncogene serine/threonine-protein kinase and Serine/... | 3 | 5 |
| Adenosine kinase inhibitor 5-(4-chlorophenyl)-6-[2-(6-morpholi... | 8 | 8 |
| Dipeptidyl peptidase 9 and Dipeptidyl peptidase 8 inhibitor Su... | 16 | 5 |
| Aurora kinase A and Aurora kinase B inhibitor 3uol family | 6 | 5 |
| Melanin-concentrating hormone receptor 1 and Potassium voltage... | 8 | 27 |
| RAC-alpha serine/threonine-protein kinase inhibitor (2S)-3-ami... | 2 | 0 |
| Mitogen-activated protein kinase 14 and LIM domain kinase 1 in... | 4 | 19 |
| Mitogen-activated protein kinase 14 inhibitor (E)-3-(2,6-dichl... | 1 | 1 |
| Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... | 3 | 11 |
| Aromatase inhibitor AGN-PC-075MV1 family | 1 | 3 |
| Protein farnesyltransferase/geranylgeranyltransferase type-1 s... | 4 | 0 |
| Mitogen-activated protein kinase 14 inhibitor AGN-PC-03XQYG fa... | 7 | 1 |
| D(4) dopamine receptor and D(2) dopamine receptor ligand 4-met... | 13 | 8 |
| Dihydrofolate reductase and Bifunctional dihydrofolate reducta... | 5 | 0 |
| Pol polyprotein and Reverse transcriptase/RNaseH inhibitor AC1... | 6 | 11 |
| Prelamin-A/C inhibitor CHEMBL1472945 family | 1 | 32 |
| Dihydrofolate reductase inhibitor 6-[[(4-chloronaphthalen-1-yl... | 2 | 1 |
| Histamine H4 receptor ligand (2Z)-5-chloro-2-[(1-methylpiperid... | 2 | 8 |
| Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... | 1 | 0 |
| Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... | 3 | 7 |
| Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... | 3 | 0 |
| Glycogen synthase kinase-3 beta and Dual specificity protein k... | 4 | 5 |
| Lysosomal Pro-X carboxypeptidase inhibitor N-[(1S)-1-(5,6-dich... | 3 | 21 |
| Corticosteroid 11-beta-dehydrogenase isozyme 1 and Nuclear rec... | 9 | 6 |
| Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... | 3 | 0 |
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... | 3 | 5 |
| Cannabinoid receptor 1 ligand SureCN675796 family | 5 | 1 |
| Nociceptin receptor and Potassium voltage-gated channel subfam... | 10 | 1 |
| Corticotropin-releasing factor receptor 1 ligand 5-(2,4-dichlo... | 5 | 17 |
| Sodium-dependent dopamine transporter and Sodium-dependent nor... | 2 | 3 |
| Histone deacetylase 1 inhibitor (E)-N-hydroxy-3-[4-[[2-(1H-pyr... | 2 | 8 |
| Somatostatin receptor type 5 and Somatostatin receptor type 2 ... | 6 | 3 |
| Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... | 9 | 2 |
| cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... | 2 | 0 |
| Mitogen-activated protein kinase 14 inhibitor 4-(2-chloropheny... | 4 | 0 |
| Tyrosine-protein kinase JAK1 inhibitor CHEMBL2206623 family | 10 | 11 |
| Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... | 4 | 2 |
| Serine/threonine-protein kinase mTOR inhibitor 5-(2-amino-3H-b... | 3 | 1 |
| Cell division cycle 7-related protein kinase and Protein DBF4 ... | 15 | 7 |
| Mast/stem cell growth factor receptor Kit and Receptor-type ty... | 8 | 3 |
| Cell division cycle 7-related protein kinase and Dual specific... | 3 | 1 |
| Protein kinase C theta type and Leucine-rich repeat serine/thr... | 1 | 1 |
| Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... | 4 | 2 |
| Cannabinoid receptor 2 ligand 8-(2-chlorophenyl)-9-cyclopropyl... | 4 | 5 |
| Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand 2-[8-... | 2 | 5 |
| Somatostatin receptor type 3 and Potassium voltage-gated chann... | 3 | 0 |
| Somatostatin receptor type 3 ligand tert-butyl 4-[(3R)-3-(5-ph... | 2 | 2 |
| D(4) dopamine receptor and Alpha-1D adrenergic receptor ligand... | 3 | 3 |
| Transient receptor potential cation channel subfamily V member... | 4 | 0 |
| Transient receptor potential cation channel subfamily V member... | 6 | 2 |
| Methionine--tRNA ligase inhibitor N-[(4R)-6,8-dibromo-1,2,3,4-... | 1 | 1 |
| D(4) dopamine receptor and D(3) dopamine receptor ligand AGN-P... | 2 | 0 |
| Mitogen-activated protein kinase 14 inhibitor imidazole 81 family | 2 | 1 |
| Tyrosine-protein kinase JAK1 inhibitor CHEMBL2152398 family | 16 | 1 |
| Smoothened homolog inhibitor N-[4-chloro-3-(5-phenyl-1H-imidaz... | 4 | 1 |
| Beta-secretase 1 and Potassium voltage-gated channel subfamily... | 3 | 4 |
| Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand N-[1-... | 5 | 3 |
| Somatostatin receptor type 3 and Potassium voltage-gated chann... | 3 | 3 |
| Tyrosine-protein kinase JAK1 inhibitor CHEMBL2206614 family | 2 | 0 |
| Mitogen-activated protein kinase 14 inhibitor 6-[2-(2,6-difluo... | 3 | 0 |
| Urokinase plasminogen activator surface receptor ligand 3-(1H-... | 4 | 0 |
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... | 7 | 4 |
| Receptor-type tyrosine-protein kinase FLT3 and Aurora kinase A... | 2 | 0 |
| Corticotropin-releasing factor receptor 1 and Corticotropin-re... | 2 | 1 |
| Adenosine kinase inhibitor 4-[2-[5-(4-chlorophenyl)-6-piperazi... | 3 | 1 |
| Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... | 6 | 5 |
| Corticotropin-releasing factor receptor 1 and Corticotropin-re... | 6 | 3 |
| Tyrosine-protein kinase JAK1 and Aurora kinase A inhibitor CHE... | 2 | 0 |
| Protein kinase C theta type and Protein kinase C delta type in... | 9 | 0 |
| Cholinesterase inhibitor 4-[4,5-diphenyl-1-[7-(1,2,3,4-tetrahy... | 2 | 1 |
| Corticotropin-releasing factor receptor 1 and Corticotropin-re... | 5 | 2 |
| Tyrosine-protein kinase JAK1 and Tyrosine-protein kinase JAK2 ... | 16 | 0 |
| Cyclin-dependent kinase 1 and Proto-oncogene tyrosine-protein ... | 5 | 13 |
| Transient receptor potential cation channel subfamily V member... | 1 | 0 |
| RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... | 16 | 7 |
| Mitogen-activated protein kinase 10 inhibitor CYCLOPROPYL-{4-[... | 2 | 1 |
| RAF proto-oncogene serine/threonine-protein kinase and Serine/... | 4 | 3 |
| Nociceptin receptor and Potassium voltage-gated channel subfam... | 5 | 2 |
| Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor AGN-P... | 3 | 0 |
| LIM domain kinase 2 inhibitor (2S)-N-cyano-N'-(3-cyanophenyl)-... | 4 | 0 |
| RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... | 10 | 0 |
| Neuropeptide Y receptor type 5 ligand SureCN6835211 family | 1 | 2 |
| Mitogen-activated protein kinase 14 inhibitor 5-[2-(2,6-dichlo... | 1 | 0 |
| D(4) dopamine receptor and D(3) dopamine receptor ligand SureC... | 1 | 0 |
| Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... | 14 | 14 |
| Prostaglandin G/H synthase 2 and Prostaglandin G/H synthase 1 ... | 4 | 1 |
| Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... | 4 | 3 |
| Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... | 3 | 0 |
| Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... | 1 | 0 |
| Tyrosine-protein kinase Lck inhibitor AGN-PC-03IU3J family | 2 | 0 |
| Type-1 angiotensin II receptor ligand SureCN7390271 family | 2 | 1 |
| Adenosine kinase inhibitor SureCN8248615 family | 2 | 3 |
| Coagulation factor X inhibitor SureCN1652469 family | 2 | 1 |
| Corticotropin-releasing factor receptor 1 ligand AGN-PC-00FF1P... | 1 | 3 |
| Transient receptor potential cation channel subfamily V member... | 1 | 0 |
| Nociceptin receptor and Mu-type opioid receptor ligand SureCN5... | 1 | 0 |
| Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... | 1 | 0 |
| Serine/threonine-protein kinase B-raf inhibitor 1-[2-[[4-[2-cy... | 2 | 0 |
| Gamma-aminobutyric acid receptor subunit pi and Gamma-aminobut... | 4 | 0 |
| Proto-oncogene tyrosine-protein kinase Src and Fibroblast grow... | 3 | 4 |
| Tyrosine-protein kinase ABL1 and Proto-oncogene tyrosine-prote... | 1 | 0 |
| Serine/threonine-protein kinase B-raf inhibitor imidazole-base... | 2 | 0 |
| Nociceptin receptor and Mu-type opioid receptor ligand 2-(3-ch... | 2 | 0 |
| Prostaglandin E synthase inhibitor AGN-PC-014WPB family | 1 | 0 |
| Pteridine reductase, putative inhibitor 1-[(3,4-dichlorophenyl... | 2 | 1 |
| Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor 3-[2-... | 9 | 0 |
| Cannabinoid receptor 1 ligand AGN-PC-077JWI family | 7 | 1 |
| 5-hydroxytryptamine receptor 3A ligand AGN-PC-077D8K family | 3 | 1 |
| Nociceptin receptor and Potassium voltage-gated channel subfam... | 1 | 0 |
| Nociceptin receptor and Mu-type opioid receptor ligand (1S,5S)... | 1 | 0 |
| Cannabinoid receptor 1 ligand AGN-PC-07CPJ5 family | 9 | 14 |
| Prostaglandin E synthase inhibitor AGN-PC-00C2TD family | 2 | 0 |
| D(4) dopamine receptor and D(2) dopamine receptor ligand SureC... | 1 | 2 |
| Adenosine receptor A1 and Adenosine receptor A2a ligand 2-(2-c... | 2 | 0 |
| Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... | 1 | 5 |
| Prostaglandin E synthase inhibitor 7-bromo-2-(2-chlorophenyl)-... | 3 | 2 |
Statistics of CFAM Database |
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
|
How to cite our database |
|
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering.
Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
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Last update by |
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2014.08.29
|
