CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM7159
Family Name Prostaglandin E2 receptor EP4 subtype ligand SureCN3567929 family
No. of Seeds 10 No. of Other Members 3
Family Centroid CFAMM00377630 Functional Category Bioactive
Superfamily Prostaglandin E2 receptor EP4 subtype and Menin Binder Superfamily
Class Class 4532

Cousin Family NamesSeedsMembers
Retinoic acid receptor alpha Ligand Tamibarotene Family 5 95
Prostaglandin G/H synthase 2 Inhibitor Mefenamic Acid Family 7 137
Cyclooxygenase Inhibitor Meclofenamic Acid Family 4 11
Intedanib family 7 54
New permeability pathways Inhibitor 5-nitro-2-(3-phenylpropyla... 1 13
Tyrosine-protein phosphatase non-receptor type 1 Ligand 2-(oxa... 3 11
Dihydroorotate dehydrogenase Inhibitor 2-(2-bromo-2-naphthamid... 1 2
3-oxo-5-alpha-steroid 4-dehydrogenase 2 Inhibitor 4-[4-(benzyl... 2 19
Cholecystokinin receptor type A Ligand VL-1499 Family 12 133
Cytosolic phospholipase A2 Inhibitor WAY-196025 Family 4 13
Prostaglandin E2 receptor EP4 subtype and Prostaglandin D2 rec... 8 17
Prostaglandin E2 receptor EP4 subtype and Prostaglandin D2 rec... 1 1
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[(1-benz... 5 2
Prostaglandin E2 receptor EP4 subtype ligand SureCN3581203 family 1 0
Prostaglandin E2 receptor EP4 subtype ligand SureCN3573573 family 3 0
Stromelysin-1 inhibitor 6-(4'-FLUORO-BIPHENYL-4-YL)-4-(3-METHY... 3 0
Chymase and Chymotrypsin-C inhibitor 3-[[2,2-difluoro-4-[[(2S)... 6 10
Integrin beta-1 and Integrin alpha-4 inhibitor 4-[[1-[2-[4-[(2... 2 8
NS5B protein inhibitor AC1NQMYP family 5 0
Prostaglandin E synthase inhibitor 4-chloro-2-[[1,3-dioxo-2-(1... 1 0
Hydroxycarboxylic acid receptor 2 and Cytochrome P450 2C8 liga... 2 0
Collagenase 3 inhibitor 4-[[4-oxo-6-(3-phenylprop-1-ynyl)quina... 2 9
Retinoic acid receptor beta and Retinoic acid receptor gamma l... 4 7
Peroxisome proliferator-activated receptor gamma ligand AGN-PC... 4 4
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand 4-[[1... 2 5
Gastrin/cholecystokinin type B receptor ligand AGN-PC-073IUK f... 2 1
Tyrosine-protein phosphatase non-receptor type 1 and Tyrosine-... 2 11
Glucocorticoid receptor ligand AGN-PC-01X8JJ family 1 0


External ID

Functional Category

Molecule Name

CFAMM00377631 CHEMBL1645134 Bioactive SureCN3578957
CFAMM00377638 CHEMBL1645155 Bioactive 4-[(1S)-1-[[5-fluoro-1-[[4-(trifluoromethyl)phenyl]methyl]-2,3-dihydroindole-7-carbonyl]amino]ethyl]benzoic acid
CFAMM00377630 CHEMBL1645137 Bioactive SureCN3567929
CFAMM00377637 CHEMBL1645140 Bioactive SureCN3564393
CFAMM00377629 CHEMBL1645133 Bioactive SureCN3578434
CFAMM00377635 CHEMBL1645151 Bioactive SureCN3576876
CFAMM00377628 CHEMBL1645154 Bioactive 4-[(1S)-1-[[5-(trifluoromethyl)-1-[[4-(trifluoromethyl)phenyl]methyl]-2,3-dihydroindole-7-carbonyl]amino]ethyl]benzoic acid
CFAMM00377627 CHEMBL1645138 Bioactive SureCN3571460
CFAMM00377626 CHEMBL1645153 Bioactive 4-[(1S)-1-[[5-chloro-1-[[4-(trifluoromethyl)phenyl]methyl]-2,3-dihydroindole-7-carbonyl]amino]ethyl]benzoic acid
CFAMM00377632 CHEMBL1645135 Bioactive SureCN3578253

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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