CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM7178
Family Name 5-hydroxytryptamine receptor 1A and D(2) dopamine receptor ligand AGN-PC-00GBA6 family
No. of Seeds 1 No. of Other Members 0
Family Centroid CFAMM00127408 Functional Category Bioactive
Superfamily cAMP and Furin Binder Superfamily
Class Class 1037

Cousin Family NamesSeedsMembers
Peptide deformylase, mitochondrial Inhibitor Trimethoprim Family 67 482
Histamine H1 receptor Ligand Mepyramine Family 5 65
Amyloid beta A4 protein Inhibitor Florbetapir F-18 Family 8 265
Serine/threonine-protein kinase Chk1 and Serine/threonine-prot... 23 121
Hypoxia-inducible factor 1-alpha Inhibitor Hif-1alpha Family 7 107
Receptor tyrosine-protein kinase erbB-2 Inhibitor CP-724714 Fa... 4 180
Insulin-like growth factor 1 receptor Ligand AEW-541 Family 12 140
5-hydroxytryptamine receptor 1A and D(3) dopamine receptor Lig... 9 115
AP26113 family 16 90
SB1518 family 7 103
Peptide deformylase, mitochondrial Inhibitor Epiroprim Family 5 68
5-hydroxytryptamine receptor 1A Ligand P-MPPI Family 33 81
Angiopoietin-1 receptor and Tyrosine-protein kinase Lck Inhibi... 3 64
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 9 Inhibi... 10 35
Melanin-concentrating hormone receptor 1 Ligand Gnf-pf-2322 Fa... 3 95
Metabotropic glutamate receptor 5 Ligand (3-ethoxy-pyridin-2-y... 3 12
Peptidyl-prolyl cis-trans isomerase A Inhibitor 3-[3-(3-benzyl... 3 34
Platelet-derived growth factor receptor alpha and Fibroblast g... 3 47
Reverse transcriptase Inhibitor UK-129485 Family 23 221
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 17 49
5-hydroxytryptamine receptor 1A Ligand CP-293019 Family 9 24
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 6 35
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 1 15
Deoxycytidine kinase inhibitor AGN-PC-07Z9C8 family 5 3
Vascular endothelial growth factor receptor 2 and Angiopoietin... 2 11
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 3
Adenosine kinase inhibitor 5-[3-(4-methoxyphenyl)propyl]-6-[2-... 2 11
Vascular endothelial growth factor receptor 2 ligand AGN-PC-09... 5 11
Cellular tumor antigen p53 and DNA polymerase beta inhibitor C... 1 15
D(2) dopamine receptor and Alpha-1B adrenergic receptor ligand... 2 8
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 14
Thyroid hormone receptor beta and Ferritin light chain ligand ... 1 35
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 5 4
Dihydrofolate reductase inhibitor AC1LA5HU family 8 4
Dihydrofolate reductase inhibitor AC1L9XPA family 6 5
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 6 13
Lethal factor and Dual specificity protein kinase CLK4 inhibit... 1 3
Inositol monophosphatase 1 inhibitor CHEMBL1588383 family 1 6
D(4) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 6
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 2 4
ALK tyrosine kinase receptor and Insulin receptor ligand SureC... 7 1
Prostaglandin D2 receptor ligand 2-[3-[2-methoxy-6-[2-(4-metho... 4 12
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 6 12
Insulin-like growth factor 1 receptor ligand 3qqu family 2 12
Ephrin type-B receptor 4 and Vascular endothelial growth facto... 2 0
Serine/threonine-protein kinase PLK1 inhibitor AGN-PC-0A9RFQ f... 2 1
Melatonin receptor type 1B ligand CHEMBL1802020 family 2 7
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 9 10
Insulin-like growth factor 1 receptor and Potassium voltage-ga... 2 2
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 2 2
Cathepsin K and Cathepsin L1 inhibitor CHEBI:43424 family 2 0
Corticotropin-releasing factor receptor 1 ligand AGN-PC-009TSL... 3 3
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 1
Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn in... 5 7
ALK tyrosine kinase receptor ligand CHEMBL1946804 family 3 0
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 2 1
Interleukin-1 receptor-associated kinase 4 and Interleukin-1 r... 4 0
Insulin-like growth factor 1 receptor ligand 4-(2,3-dihydroind... 1 0
Adenosine kinase inhibitor (2R,3R,4R)-2-[4-(2,3-dihydro-1,4-be... 5 2
Wee1-like protein kinase and ALK tyrosine kinase receptor liga... 1 9
Rho-associated protein kinase 1 and cAMP-dependent protein kin... 1 11
Epidermal growth factor receptor ligand N-[3-[7-[2-methoxy-4-(... 9 3
D(4) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 2 2
Tyrosine-protein kinase Lck and Proto-oncogene tyrosine-protei... 6 13
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 18 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 0
Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... 1 0
Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... 1 0
Nitric oxide synthase, inducible inhibitor 2-[1-(2-imidazol-1-... 4 3
Receptor tyrosine-protein kinase erbB-2 ligand SureCN4463897 f... 3 2
TRAF2 and NCK-interacting protein kinase and Serine/threonine-... 2 2
TRAF2 and NCK-interacting protein kinase inhibitor 4-methoxy-3... 4 1
Histone-arginine methyltransferase CARM1 inhibitor AGN-PC-00HE... 4 4
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor N-(5-... 2 1
Vascular endothelial growth factor receptor 2 and Angiopoietin... 3 3
Cathepsin K and Cathepsin S inhibitor SureCN4135077 family 2 0
Mitogen-activated protein kinase 14 inhibitor SureCN4913214 fa... 1 2
Dihydrofolate reductase inhibitor AC1LAPW3 family 3 0
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 3 10
Dihydrofolate reductase inhibitor AGN-PC-001U7R family 3 0
Dihydrofolate reductase and Dihydrofolate reductase type 1 inh... 8 1
Tyrosine-protein kinase Lck and Vascular endothelial growth fa... 1 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 6 0
Transient receptor potential cation channel subfamily V member... 18 1
Insulin-like growth factor 1 receptor and Mitogen-activated pr... 15 1
Tyrosine-protein kinase SYK and Tyrosine-protein kinase ZAP-70... 3 8
Cathepsin S and Cathepsin K inhibitor AGN-PC-078ZDC family 4 2
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 0
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 3 1
Epidermal growth factor receptor ligand Pyrido[3,4-d]pyrimidin... 3 1
Bifunctional epoxide hydrolase 2 and Voltage-dependent L-type ... 2 1
LIM domain kinase 2 and LIM domain kinase 1 inhibitor SureCN36... 1 1
TGF-beta receptor type-1 ligand SureCN373216 family 3 14
Protein kinase C theta type inhibitor SureCN3953579 family 2 1
Nuclear receptor ROR-gamma and Cytochrome P450 3A4 ligand NCGC... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name


Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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