CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM7183
Family Name Neprilysin inhibitor (2S)-2-methyl-3-oxo-3-[[(2S)-1-phenyl-3-sulfanylpropan-2-yl]amino]propanoic acid family
No. of Seeds 5 No. of Other Members 2
Family Centroid CFAMM00377758 Functional Category Bioactive
Superfamily Angiotensin-converting enzyme and Neprilysin Binder Superfamily 2
Class Class 1538

Cousin Family NamesSeedsMembers
Penicillin binding protein inhibitor β-lactam aminopenicillin ... 12 359
Angiotensin-converting enzyme inhibitor Dicarboxylate-containi... 16 374
Angiotensin-converting enzyme Inhibitor Spirapril Family 17 86
Angiotensin-converting enzyme inhibitor Dicarboxylate-containi... 7 54
ATP-sensitive inward rectifier potassium channel 10 Ligand Nat... 3 233
Angiotensin-converting enzyme and Neprilysin Inhibitor M100,24... 18 60
Neprilysin Inhibitor Thiorphan Family 41 68
Vasopeptidase Inhibitor Sampatrilat Family 25 9
Neuromedin-K receptor Ligand Senktide Family 15 22
Cathepsin F and Cruzipain Inhibitor WRR-99 Family 13 131
Beta-secretase 1 Inhibitor MMI-175 Family 30 137
Farnesyltransferase beta subunit, putative and Protein farnesy... 24 82
Plasmepsin-1 Inhibitor SC-5003 Family 93 173
Cathepsin B and Cathepsin S Inhibitor Ac-hphe-leu-ala-leuvsme ... 17 51
Histone deacetylase 1 and Histone deacetylase 4 Inhibitor Azum... 3 10
Integrin alpha-V Inhibitor C[rgdf-(3s)-carboxymorpholine] Family 10 2
DNA (cytosine-5)-methyltransferase 3B Inhibitor NSC-154957 Family 2 3
Genome polyprotein Inhibitor Acasp-glu-dif-glu-cha-cys Family 13 17
Genome polyprotein Inhibitor Acasp-glu-met-glu-cha-cys Family 3 6
Genome polyprotein Inhibitor Acdif-ile-cha-cys Family 37 96
Pol polyprotein inhibitor Lysine Sulfonamide 11c family 3 73
Neprilysin inhibitor SureCN7437961 family 2 6
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 6
Neprilysin inhibitor AGN-PC-02K4O6 family 2 0
Neprilysin inhibitor methyl (2S)-4-methyl-2-[[2-(sulfanylmethy... 3 0


External ID

Functional Category

Molecule Name

CFAMM00377759 CHEMBL349404 Bioactive 3-oxo-3-[[(2S)-1-phenyl-3-sulfanylpropan-2-yl]amino]propanoic acid
CFAMM00377758 CHEMBL165499 Bioactive (2S)-2-methyl-3-oxo-3-[[(2S)-1-phenyl-3-sulfanylpropan-2-yl]amino]propanoic acid
CFAMM00377757 CHEMBL165744 Bioactive (2R)-4-methyl-2-[[(2S)-1-phenyl-3-sulfanylpropan-2-yl]carbamoyl]pentanoic acid
CFAMM00377763 CHEMBL164955 Bioactive (2S)-4-methyl-2-[[(2S)-1-phenyl-3-sulfanylpropan-2-yl]carbamoyl]pentanoic acid
CFAMM00377761 CHEMBL165922 Bioactive (2R)-2-methyl-3-oxo-3-[[(2S)-1-phenyl-3-sulfanylpropan-2-yl]amino]propanoic acid

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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