CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM7190
Family Name Adenosine receptor A1 and Adenosine receptor A3 ligand AGN-PC-08WSME family
No. of Seeds 6 No. of Other Members 8
Family Centroid CFAMM00377843 Functional Category Bioactive with Natural Product
Superfamily Adenosine receptor A1 and Adenosine receptor A3 Binder Superfamily 7
Class Class 377

Cousin Family NamesSeedsMembers
Alpha-1D adrenergic receptor Ligand Terazosin Family 28 638
Peptide deformylase, mitochondrial Inhibitor Trimetrexate Family 4 311
Epidermal growth factor receptor Ligand Gefitinib Family 26 600
Peptide deformylase, mitochondrial Inhibitor Trimethoprim Family 67 482
Corticotropin-releasing factor receptor 1 Ligand CRF-1 Antagon... 29 421
Hepatocyte growth factor receptor and Vascular endothelial gro... 28 178
Receptor tyrosine-protein kinase erbB-2 Inhibitor CP-724714 Fa... 4 180
Vascular endothelial growth factor receptor 2 Ligand Cediranib... 8 38
Insulin-like growth factor 1 receptor Ligand AEW-541 Family 12 140
Abelson tyrosine-protein kinase 2 and Proto-oncogene tyrosine-... 25 40
SB1518 family 7 103
Peptide deformylase, mitochondrial Inhibitor Epiroprim Family 5 68
Tyrosine kinase Inhibitor PKI166 Family 17 198
Peptide deformylase, mitochondrial Inhibitor 5-(4-methoxypheno... 5 61
Angiopoietin-1 receptor and Tyrosine-protein kinase Lck Inhibi... 3 64
Peptide deformylase, mitochondrial Inhibitor 8-(2,3,4-trimetho... 8 15
Platelet-derived growth factor receptor alpha and Platelet-der... 2 9
Adenosine receptor A1 and Adenosine receptor A3 Ligand 4-metho... 1 16
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 4 Inhibi... 19 48
Adenosine receptor A1 and Adenosine receptor A3 Ligand 2-(4-me... 3 23
Melanin-concentrating hormone receptor 1 Ligand Gnf-pf-2322 Fa... 3 95
TGF-beta receptor type-1 Ligand SB-431542 Family 2 42
Epidermal growth factor receptor Ligand 4-(5-bromoindole-3-yl)... 6 15
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 17 49
Sodium channel protein type 5 subunit alpha Ligand Enecadin Fa... 1 11
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor SK&F-96... 5 83
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 1 15
3-phosphoinositide-dependent protein kinase 1 and Ribosomal pr... 10 4
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 2 3
Bifunctional dihydrofolate reductase-thymidylate synthase inhi... 5 45
Lysine--tRNA ligase and Dual specificity protein kinase CLK4 i... 4 27
Cathepsin S and Cathepsin K inhibitor AGN-PC-088VBO family 3 11
Adenosine kinase inhibitor 5-[3-(4-methoxyphenyl)propyl]-6-[2-... 2 11
Proto-oncogene tyrosine-protein kinase Src and Phosphatidylino... 4 20
Translocator protein inhibitor AGN-PC-080ILF family 9 3
Survival motor neuron protein inhibitor CHEMBL1307497 family 1 2
Dual specificity protein kinase CLK1 and Dual specificity prot... 2 14
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 8 12
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor CHEMBL2... 3 8
Prostaglandin D2 receptor ligand 3-[2-methoxy-6-[2-(4-methoxyp... 2 12
Receptor-type tyrosine-protein kinase FLT3 ligand 2-(6,7-dimet... 3 2
Prelamin-A/C and Nuclear receptor ROR-gamma ligand CHEMBL13704... 1 7
Dual specificity tyrosine-phosphorylation-regulated kinase 1A ... 3 20
Alpha-1D adrenergic receptor and Alpha-1B adrenergic receptor ... 6 9
Alpha-1A adrenergic receptor ligand 6,7-dimethoxy-2-[4-[(5-oxi... 3 1
Alpha-1A adrenergic receptor ligand 4-[4-(4-amino-6,7-dimethox... 3 0
Dual specificity protein kinase CLK4 and Dual specificity tyro... 1 14
Adenosine kinase inhibitor SureCN8134468 family 3 7
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 6 13
Cellular tumor antigen p53 and Microtubule-associated protein ... 1 6
Tyrosine-protein kinase JAK2 inhibitor 5-(3-methoxyphenyl)-N-[... 2 11
Equilibrative nucleoside transporter 1 inhibitor SureCN9046933... 2 9
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 2 4
Prostaglandin D2 receptor ligand 2-[3-[2-methoxy-6-[2-(4-metho... 4 12
Prostaglandin D2 receptor ligand 2-methoxy-N-[2-(4-methoxyphen... 2 5
Prostaglandin D2 receptor ligand 1-[3-[2-methoxy-6-[2-(4-metho... 6 16
Prostaglandin D2 receptor ligand 2-methoxy-N-[2-(4-methoxyphen... 3 21
Serine/threonine-protein kinase Chk2 and Serine/threonine-prot... 1 0
Adenosine receptor A3 ligand AGN-PC-08WSLM family 5 22
Calmodulin-domain protein kinase 1 and Tyrosine-protein kinase... 5 5
Alpha-1D adrenergic receptor and Alpha-1B adrenergic receptor ... 1 0
Dihydrofolate reductase inhibitor 7-(3,4-dimethoxyphenyl)-6-me... 1 3
Dihydrofolate reductase inhibitor 7-(2-ethoxynaphthalen-1-yl)-... 3 2
Melanin-concentrating hormone receptor 1 ligand AGN-PC-075FPC ... 6 1
Corticotropin-releasing factor receptor 1 ligand Pyridopyrazin... 2 1
Platelet-derived growth factor receptor beta and Receptor-type... 5 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 3
Macrophage colony-stimulating factor 1 receptor and Ephrin typ... 1 0
Vascular endothelial growth factor receptor 2 ligand AGN-PC-00... 4 0
Vascular endothelial growth factor receptor 2 ligand AGN-PC-00... 8 1
Receptor tyrosine-protein kinase erbB-2 and Tyrosine-protein k... 1 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 6
ALK tyrosine kinase receptor and Insulin-like growth factor 1 ... 1 4
Vascular endothelial growth factor receptor 2 and Aurora kinas... 4 3
Tyrosine-protein kinase Lck inhibitor AGN-PC-0762WF family 2 0
Acetylcholinesterase and Butyrylcholinesterase inhibitor (E)-3... 4 5
Cholinesterase and Acetylcholinesterase inhibitor 6-[2-methoxy... 12 6
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Nitric oxide synthase, inducible inhibitor SureCN5194847 family 24 48
Bifunctional dihydrofolate reductase-thymidylate synthase inhi... 3 5
Transient receptor potential cation channel subfamily V member... 2 4
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 2
Histone-lysine N-methyltransferase EHMT2 inhibitor N-(1-cyclop... 1 2
Cathepsin K and Cathepsin S inhibitor SureCN4135077 family 2 0
Melanin-concentrating hormone receptor 1 ligand (1S,3S)-3-N-(7... 2 2
Adenosine receptor A1 and Adenosine receptor A2a ligand 2-amin... 4 3
Adenosine receptor A1 and Adenosine receptor A2a ligand N-[4-(... 4 0
Epidermal growth factor receptor ligand SureCN2989664 family 5 2
Bifunctional dihydrofolate reductase-thymidylate synthase inhi... 2 6
Adenosine kinase inhibitor SureCN8139139 family 1 1
Vascular endothelial growth factor receptor 2 ligand 2-aminobe... 1 0
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 7 5
Adenosine receptor A2a ligand AGN-PC-077RYH family 16 5
Adenosine receptor A2a ligand AGN-PC-077RYF family 3 0
Adenosine receptor A1 ligand BAS 00727702 family 1 4
Inositol monophosphatase 1 and Prelamin-A/C inhibitor GNF-Pf-3... 1 5
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 6 1
Epidermal growth factor receptor ligand 4-Anilinoquinazoline d... 2 0
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 1 1
Dual specificity protein kinase CLK4 and Dual specificity tyro... 6 2
Dual specificity protein kinase CLK4 and Dual specificity prot... 1 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4D and cAMP-speci... 4 3
Vascular endothelial growth factor receptor 2 and Serine/threo... 4 2
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN7... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00377851 CHEMBL2312110 Bioactive N-[2,6-bis(3,4-dimethoxyphenyl)pyrimidin-4-yl]acetamide
CFAMM00377847 CHEMBL1771456 Bioactive SureCN3109678

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27430 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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