CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM7197
Family Name Transient receptor potential cation channel subfamily M member 8 and Transient receptor potential M8 protein ligand (3Z)-3-[4-(trifluoromethyl)-6-[2-(trifluoromethyl)phenyl]benzimidazol-2-ylidene]-1-oxa-2-azaspiro[4.5]decane family
No. of Seeds 9 No. of Other Members 0
Family Centroid CFAMM00377897 Functional Category Bioactive
Superfamily Transient receptor potential M8 protein and Cytochrome P450 2C9 Binder Superfamily
Class Class 1983

Cousin Family NamesSeedsMembers
Histamine H1 receptor Ligand Mizolastine Family 14 603
C-X-C chemokine receptor type 4 Ligand AMD-070 Family 12 800
JNJ-39439335 family 5 11
Tryptase Inhibitor Babim Family 12 90
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2,6-di... 13 14
Vascular endothelial growth factor receptor 2 Ligand 6-(1h-ben... 2 5
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... 18 109
Mitogen-activated protein kinase 3 and RAF proto-oncogene seri... 8 5
Alpha-1A adrenergic receptor Ligand A-315456 Family 7 17
Dipeptidyl peptidase 4 Inhibitor (5-phenyl-3h-benzo[d]imidazol... 5 13
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Sodium channel protein type 1 subunit alpha and Sodium channel... 10 14
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 4 3
Neuropeptide Y receptor type 5 and Potassium voltage-gated cha... 6 0
Transient receptor potential M8 protein ligand 2-[(E)-2-(oxan-... 5 3
Transient receptor potential M8 protein and Cytochrome P450 2C... 4 0
Transient receptor potential M8 protein and Cytochrome P450 2C... 1 0
Sodium-dependent dopamine transporter and Sodium-dependent nor... 2 3
Mitogen-activated protein kinase 14 inhibitor 6-[5-(2,4-difluo... 9 3
Protein kinase C zeta type and Cyclin-dependent kinase 2 inhib... 2 13
Neuronal acetylcholine receptor subunit beta-2 and Neuronal ac... 10 6
Melanin-concentrating hormone receptor 1 ligand AGN-PC-00BSP9 ... 6 12
Mitogen-activated protein kinase 14 inhibitor 6-[2-(2,6-difluo... 3 0
Urokinase plasminogen activator surface receptor ligand 3-(1H-... 4 0
Type-1 angiotensin II receptor ligand AGN-PC-04X8EF family 1 1
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 2 0
Prostaglandin E synthase inhibitor AGN-PC-04SSMB family 6 0


External ID

Functional Category

Molecule Name

CFAMM00377897 CHEMBL1650511 Bioactive (3Z)-3-[4-(trifluoromethyl)-6-[2-(trifluoromethyl)phenyl]benzimidazol-2-ylidene]-1-oxa-2-azaspiro[4.5]decane
CFAMM00377896 CHEMBL1650525 Bioactive (3Z)-3-[6-(2-fluorophenyl)-4-(trifluoromethyl)benzimidazol-2-ylidene]-1-oxa-2-azaspiro[4.5]decane
CFAMM00377895 CHEMBL1650512 Bioactive (3E)-3-[5-(2-fluorophenyl)benzimidazol-2-ylidene]-1-oxa-2-azaspiro[4.5]decane
CFAMM00377901 CHEMBL1650531 Bioactive (3Z)-3-[4-(trifluoromethyl)-6-[2-(trifluoromethyl)phenyl]benzimidazol-2-ylidene]-1,8-dioxa-2-azaspiro[4.5]decane
CFAMM00377894 CHEMBL1650521 Bioactive (3Z)-3-[4-fluoro-6-[2-(trifluoromethyl)phenyl]benzimidazol-2-ylidene]-1-oxa-2-azaspiro[4.5]decane
CFAMM00377900 CHEMBL1650518 Bioactive (3E)-3-[5-(2,6-difluorophenyl)benzimidazol-2-ylidene]-1-oxa-2-azaspiro[4.5]decane
CFAMM00377893 CHEMBL1650523 Bioactive (2Z)-2-(1-oxa-2-azaspiro[4.5]decan-3-ylidene)-6-[2-(trifluoromethyl)phenyl]benzimidazole-4-carbonitrile
CFAMM00377899 CHEMBL1650528 Bioactive 3-[(2Z)-2-(1-oxa-2-azaspiro[4.5]decan-3-ylidene)-6-[2-(trifluoromethyl)phenyl]benzimidazol-4-yl]propan-1-ol
CFAMM00377898 CHEMBL1650529 Bioactive (3E)-3-[5-[2-(trifluoromethyl)phenyl]benzimidazol-2-ylidene]-1,8-dioxa-2-azaspiro[4.5]decane

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

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Professor in Department of Pharmacy
National University of Singapore, Singapore

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