CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

Family Name Calpain-2 catalytic subunit and Calpain-1 catalytic subunit inhibitor benzyl N-[1-[[1-[[2-[3,4-bis(phenylmethoxy)phenyl]-2-hydroxyethyl]amino]-1,2-dioxopentan-3-yl]amino]-4-methyl-1-oxopentan-2-yl]carbamate family
No. of Seeds 5 No. of Other Members 2
Family Centroid CFAMM00306711 Functional Category Bioactive
Superfamily Calpain-1 catalytic subunit and Pol polyprotein Binder Superfamily
Class Class 609

Cousin Family NamesSeedsMembers
Angiotensin-converting enzyme Inhibitor Moexipril Family 5 469
Beta adrenergic receptor Ligand Dipivefrin Family 3 55
HIV-1 protease Inhibitor Lopinavir Family 4 25
Alpha adrenergic receptor Ligand Bevantolol Family 4 48
Growth hormone secretagogue receptor type 1 Ligand TZP-101 Family 28 263
Ceramide glucosyltransferase Inhibitor Eliglustat Tartrate Family 3 2
Voltage-dependent L-type calcium channel Ligand PD173212 Family 24 104
Cathepsin F Inhibitor Benzoyl-tyrosine-alanine-methyl Ketone F... 34 55
Plasmepsin-1 and Plasmepsin-2 Inhibitor PS-777621 Family 11 13
Tubulin beta chain Inhibitor 6-ile-ustiloxin Family 4 3
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 152 36
Pol polyprotein inhibitor 180968-31-4 family 8 13
Peptidyl-prolyl cis-trans isomerase FKBP1A inhibitor 2-[3-[(1R... 9 46
Neprilysin and Angiotensin-converting enzyme inhibitor AGN-PC-... 3 7
Transient receptor potential cation channel subfamily V member... 3 18
Calpain-1 catalytic subunit and Cathepsin B inhibitor AGN-PC-0... 6 1
Calpain-2 catalytic subunit and Calpain-1 catalytic subunit in... 6 1
Prothrombin inhibitor (2S)-N-[(4-aminocyclohexyl)methyl]-1-[2-... 1 0
Pol polyprotein inhibitor MDL 74538 family 11 1


External ID

Functional Category

Molecule Name

CFAMM00306709 CHEMBL133806 Bioactive AGN-PC-075LAD
CFAMM00306708 CHEMBL101962 Bioactive (2S)-N-[(2S,3R,4R,5S)-3,4-dihydroxy-5-[[(2S)-3-methyl-2-[[2-(3,4,5-trimethoxyphenyl)acetyl]amino]butanoyl]amino]-1,6-diphenylhexan-2-yl]-3-methyl-2-[[2-(3,4,5-trimethoxyphenyl)acetyl]amino]butanamide
CFAMM00306707 CHEMBL130359 Bioactive AGN-PC-075LAS
CFAMM00306705 CHEMBL101111 Bioactive (2S)-N-[(2S,4S,5S)-4-hydroxy-5-[[(2S)-3-methyl-2-[[2-(3,4,5-trimethoxyphenyl)acetyl]amino]butanoyl]amino]-1,6-diphenylhexan-2-yl]-3-methyl-2-[[2-(3,4,5-trimethoxyphenyl)acetyl]amino]butanamide
CFAMM00306711 CHEMBL130146 Bioactive benzyl N-[1-[[1-[[2-[3,4-bis(phenylmethoxy)phenyl]-2-hydroxyethyl]amino]-1,2-dioxopentan-3-yl]amino]-4-methyl-1-oxopentan-2-yl]carbamate

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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