CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM7209
Family Name Acetylcholinesterase inhibitor CHEMBL1651140 family
No. of Seeds 4 No. of Other Members 4
Family Centroid CFAMM00378125 Functional Category Bioactive
Superfamily Acetylcholinesterase and Cytochrome P450 11B1, mitochondrial Binder Superfamily
Class Class 1542

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 14 2769
5-hydroxytryptamine receptor 3A Ligand Dolasetron Family 12 171
Melatonin receptor type 1A Ligand Melatonin Family 20 988
Gastrin/cholecystokinin type B receptor ligand oligopeptide Ce... 35 209
Somatostatin receptor type 2 ligand octapeptide Lanreotide Family 93 156
ostatin receptor 5 Ligand Pasireotide Diaspartate Family 11 151
DNA Binder Elliptinium Acetate Family 11 116
Hepatocyte growth factor receptor Ligand Arq 197 Family 10 400
Dihydroorotate dehydrogenase Inhibitor Brequinar Family 9 122
Retinoic acid receptor alpha Ligand LG100268 Family 2 33
Mitogen-activated protein kinase 14 Inhibitor Losmapimod Family 5 154
Glutamate receptor AMPA subtype Ligand CX-516 Family 9 24
D(3) dopamine receptor Ligand SB-277011 Family 13 178
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 12 197
Genomic RNA for RNA-dependent RNA polymerase gene (clone HCV-J... 4 42
TGF-beta receptor type-1 Ligand LY2157299 Family 13 56
Cholecystokinin receptor type A Ligand A-71378 Family 77 23
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
Lethal factor Inhibitor GM6001 Family 50 435
XL-888 family 16 85
5-hydroxytryptamine receptor 3B and 5-hydroxytryptamine recept... 11 41
Dihydroorotate dehydrogenase Inhibitor Cinchoninic Acid Family 1 21
5-hydroxytryptamine receptor 1B Ligand GR55562 Family 3 45
5-hydroxytryptamine receptor 1A Ligand Sun N4057 Family 2 86
Carbonic anhydrase 2 Inhibitor N-[2-(1h-indol-5-yl)-butyl]-4-s... 12 70
cGMP-inhibited 3',5'-cyclic phosphodiesterase A and Cytochrome... 9 40
Cannabinoid receptor 2 Ligand JWH-202 Family 9 172
DNA-dependent protein kinase catalytic subunit Inhibitor 8-(1h... 3 85
Serine/threonine-protein kinase Chk1 Inhibitor A-432411 Family 4 70
Poly [ADP-ribose] polymerase 1 Inhibitor 1,7,8,9-tetrahydro-1,... 19 64
Delta-type opioid receptor and Gastrin/cholecystokinin type B ... 19 0
Platelet-derived growth factor receptor alpha and Platelet-der... 4 54
Lethal factor Inhibitor 3-(2,5-dimethyl-1h-pyrrol-1-yl)benzoic... 2 44
Serine/threonine-protein kinase Chk1 and Wee1-like protein kin... 2 101
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-3... 14 214
Acetylcholinesterase and Cholinesterase Inhibitor 6-hydroxy-1,... 4 2
Cannabinoid receptor 1 Ligand N-phenyl-5,6-dip-tolylpyrazine-2... 11 26
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[c... 20 18
Fatty acid-binding protein, adipocyte Inhibitor 1-benzyl-2,3-d... 1 8
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 5-... 4 10
D(2) dopamine receptor and D(3) dopamine receptor Ligand D-366... 5 75
DNA (cytosine-5)-methyltransferase 3B Inhibitor NSC-345763 Family 1 2
Type-1 angiotensin II receptor Ligand [sar1,tdf3]angii Family 135 2
Mitogen-activated protein kinase 14 Inhibitor N-(4-fluorobenzy... 19 32
Kinesin-like protein KIF11 Inhibitor Methyl 7-tert-butyl-9h-ca... 2 9
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 24 64
Arachidonate 5-lipoxygenase Inhibitor TZI-41127 Family 7 34
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 3 29
Glutamate receptor 1 Ligand Piriqualone Family 8 67
Endothelin B receptor Ligand IRL-2500 Family 34 87
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 12 72
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 18 72
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 13 15
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Acetylcholinesterase Inhibitor 10-hydroxy-infractopicrin Family 1 3
Acetylcholinesterase and Cholinesterase Inhibitor 3-(2-diethyl... 12 160
Phospholipase A2 Inhibitor Hyrtiosulawesine Family 1 3
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 46 0
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 22 57
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 6 0
Dipeptidyl peptidase 4 inhibitor (1S,3S,5S)-2-[(2S)-2-amino-2-... 3 5
Vasopressin V1a receptor and Vasopressin V2 receptor ligand (3... 4 41
Melanocortin receptor 4 and Potassium voltage-gated channel su... 2 12
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 3 28
Gonadotropin-releasing hormone receptor ligand 1-(3-azabicyclo... 5 0
Vascular endothelial growth factor receptor 2 ligand indolyl q... 4 3
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 14 48
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand [(4R,... 3 7
Sodium-dependent serotonin transporter and Sodium-dependent do... 10 2
Renin inhibitor SureCN1144364 family 3 15
Histamine H3 receptor and Cytochrome P450 2D6 ligand AGN-PC-00... 18 32
Histamine H3 receptor ligand AGN-PC-00BG7Z family 11 49
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 10 50
Glutamate receptor ionotropic, NMDA 2D and Glutamate receptor ... 2 21
MAP kinase-activated protein kinase 2 and Mitogen-activated pr... 5 2
Vascular endothelial growth factor receptor 2 ligand AGN-PC-05... 2 2
Retinoic acid receptor alpha and Retinoic acid receptor beta l... 1 2
Somatostatin receptor type 2 ligand tert-butyl (2S)-6-amino-2-... 1 2
Growth hormone secretagogue receptor type 1 ligand 2-amino-N-[... 3 3
Cellular tumor antigen p53 and Beta-lactamase inhibitor CHEMBL... 1 36
Survival motor neuron protein and Nonstructural protein 1 inhi... 1 18
Prelamin-A/C and Microtubule-associated protein tau inhibitor ... 1 16
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-3-... 8 3
Cellular tumor antigen p53 and Microtubule-associated protein ... 1 15
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 4 11
Cannabinoid receptor 2 ligand [(4R,4aS,8aR)-4-hydroxy-4-phenyl... 2 41
Histamine H3 receptor ligand SureCN2784306 family 5 3
Metabotropic glutamate receptor 1 ligand [11C]JNJ-16567083 family 9 2
Acetylcholinesterase inhibitor CHEMBL1651131 family 6 9
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 18 3
Cytochrome P450 11B2, mitochondrial and Cytochrome P450 11B1, ... 9 7
Cytochrome P450 11B2, mitochondrial and Cytochrome P450 11B1, ... 2 2
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand [(4S,... 5 2
Histone deacetylase inhibitor (3S,6S,9S,12R)-3-[(2S)-butan-2-y... 1 0
Sodium-dependent serotonin transporter inhibitor SureCN7536104... 6 2
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 1
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 5 2
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 3 0
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 2 3
NS5B protein inhibitor AC1O5AET family 3 1
Renin and Potassium voltage-gated channel subfamily H member 2... 13 11
Cyclin-dependent kinase 4 and Cyclin-dependent kinase 2 inhibi... 3 1
RAC-alpha serine/threonine-protein kinase inhibitor 5-[5-[(2S)... 14 2
Rho-associated protein kinase 2 and Rho-associated protein kin... 1 3
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 3 1
D(3) dopamine receptor ligand AGN-PC-075Z0O family 2 3
Histone deacetylase 6 and Histone deacetylase 1 inhibitor N-hy... 3 2
Prostaglandin D2 receptor 2 ligand 2-[1-(4-benzamidobenzoyl)is... 4 9
Substance-P receptor ligand [3,5-bis(trifluoromethyl)phenyl]-[... 17 1
Substance-P receptor ligand (3R)-4-[3,5-bis(trifluoromethyl)be... 2 3
Histamine H3 receptor ligand 2-[4-(1-methylpyrrole-2-carbonyl)... 3 4
High affinity nerve growth factor receptor and BDNF/NT-3 growt... 4 3
Egl nine homolog 1 inhibitor 2-[5-methyl-6-[[1-oxo-2-(4-phenyl... 4 3
Substance-P receptor ligand 1-[4-(2-methoxyphenyl)piperazin-1-... 11 12
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 12 0
Sodium-dependent serotonin transporter and Alpha-1B adrenergic... 42 20
Glutamate receptor ionotropic, NMDA 2B ligand N-[3-[2-(4-benzy... 2 0
RAC-beta serine/threonine-protein kinase and 3-phosphoinositid... 1 1
RAC-beta serine/threonine-protein kinase and 3-phosphoinositid... 11 4
Transient receptor potential cation channel subfamily V member... 1 5
Coagulation factor X inhibitor 3-chloro-N-[(1S,2S)-2-[[4-(2-ox... 22 3
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 1 1
Beta-2 adrenergic receptor ligand SureCN5346426 family 8 0
Hydroxycarboxylic acid receptor 2 and Cytochrome P450 2C9 liga... 2 6
Beta-2 adrenergic receptor ligand SureCN4598646 family 7 7
Estrogen receptor and Estrogen receptor beta ligand N-[(2R)-4-... 7 11
Serine/threonine-protein kinase PLK4 inhibitor (3E)-5-methoxy-... 4 0
Egl nine homolog 1 inhibitor 2-(2-methoxy-4-phenylphenyl)-8-[(... 1 0
Phospholipase D1 and Phospholipase D2 inhibitor SureCN10311349... 2 14
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 4 1
Wee1-like protein kinase and Serine/threonine-protein kinase C... 8 0
Gonadotropin-releasing hormone receptor ligand SureCN7905635 f... 2 2
Histone deacetylase 3 and Histone deacetylase 9 inhibitor AGN-... 4 20
Platelet-activating factor receptor ligand (4R)-N-(3-benzoylph... 2 1
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 6 8
Coagulation factor X and Prothrombin inhibitor SureCN6434488 f... 3 13
Cannabinoid receptor 1 ligand (4-hydroxynaphthalen-1-yl)-[1-(2... 2 0
Vasopressin V2 receptor and Vasopressin V1a receptor ligand Su... 2 2
Substance-P receptor and Substance-K receptor ligand N-methyl-... 2 2
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 1 1
KiSS-1 receptor ligand N-[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-[[(2S)-... 1 0
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 0
B2 bradykinin receptor ligand 1-N,3-N-dimethyl-4-[methyl-[2-[[... 4 1
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 3 2
Mitogen-activated protein kinase 1 and Aurora kinase A inhibit... 1 0
Peroxisome proliferator-activated receptor gamma ligand AGN-PC... 4 4
Mitogen-activated protein kinase 14 inhibitor SureCN4508019 fa... 1 0
Survival motor neuron protein and Arachidonate 15-lipoxygenase... 1 2
Microtubule-associated protein tau and Glycogen synthase kinas... 9 15
Mitogen-activated protein kinase 14 inhibitor AGN-PC-08866Z fa... 2 0
Glutamate carboxypeptidase 2 inhibitor 1-[(3-carboxyphenyl)met... 4 11
Gamma-aminobutyric acid receptor subunit pi and Gamma-aminobut... 1 1
Lutropin-choriogonadotropic hormone receptor ligand 5-[2-(4-te... 1 1
Calcium/calmodulin-dependent protein kinase type II subunit de... 1 0
ATP-dependent DNA helicase Q1 and Ras-related protein Rab-9A i... 1 1
Coagulation factor VII and Tissue factor inhibitor 5-azaindole... 1 0
Putative NP ZINC15919780 Family 2 0
1-[(5-hydroxy-1H-indol-3-yl)methyl]-5'-methyl-5-phenylspiro[1,... 4 0
2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-2-ium-8-carboxylate N... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00378120 CHEMBL1651139 Bioactive CHEMBL1651139
CFAMM00378126 CHEMBL1651249 Bioactive CHEMBL1651249
CFAMM00378125 CHEMBL1651140 Bioactive CHEMBL1651140

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26190 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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