CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM7215
Family Name Cathepsin K and Cathepsin L1 inhibitor 1-[(2S)-1-[[cyano(methyl)amino]-methylamino]-4-methyl-1-oxopentan-2-yl]-3-phenylurea family
No. of Seeds 2 No. of Other Members 1
Family Centroid CFAMM00378165 Functional Category Bioactive
Superfamily Cathepsin K and Cathepsin S Binder Superfamily 9
Class Class 1613

Cousin Family NamesSeedsMembers
Mu-type opioid receptor Ligand Fentanyl Family 9 647
Sodium channel Ligand xylidine derivative Mepivacaine Family 10 114
D(2) dopamine receptor ligand diphenylbutylpiperidine derivati... 43 161
Histone deacetylase 1 Inhibitor Vorinostat Family 26 138
Serine/threonine-protein kinase mTOR Inhibitor CC-223 Family 12 135
Nociceptin receptor Ligand J-113397 Family 3 14
Bifunctional epoxide hydrolase 2 Inhibitor 1-cyclohexyl-3-phen... 5 65
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor 6-(2... 1 1
Histone Deacetylase 8 Inhibitor 6-(2-mercaptoacetamido)-n-phen... 4 8
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 14 110
Leukotriene A-4 hydrolase Inhibitor N5-[4-(n-phenylamino)pheny... 2 3
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 1 1
5-hydroxytryptamine receptor 3A Ligand 1-(biphenyl-4-yl)-3-(4-... 20 67
Bifunctional epoxide hydrolase 2 Inhibitor 1-phenyl-3-(1-propi... 22 183
Tyrosinase Inhibitor 1-hydroxy-3-(4-(trifluoromethyl)phenyl)ur... 2 3
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 3 3
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 5 2
Neutrophil elastase inhibitor SureCN7448165 family 2 4
Cannabinoid receptor 2 ligand SureCN738026 family 5 68
Lethal factor inhibitor (2R)-2-(4-fluoro-3,5-dimethylanilino)-... 11 8
Mitogen-activated protein kinase 1 and M17 leucyl aminopeptida... 1 21
Neutrophil elastase inhibitor SureCN7423499 family 5 1
Chymotrypsin-like elastase family member 1 and Neutrophil elas... 1 12
72 kDa type IV collagenase and Stromelysin-1 inhibitor (2R)-N-... 2 7
Substance-P receptor ligand (2S,4S)-2-N-[3-(diethylamino)propy... 2 7
Matrix metalloproteinase-9 and Stromelysin-1 inhibitor N-[(2S)... 1 1
D(4) dopamine receptor ligand 1-Piperidineacetamide, 4-(2-cyan... 3 7
Dipeptidyl peptidase 4 inhibitor (2S)-1-[(2S,4S)-4-anilinopyrr... 2 13
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 11 3
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 3 1
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 11 4
Cathepsin K and Cathepsin B inhibitor AGN-PC-076LFZ family 1 0
Neutrophil elastase inhibitor 1-[(2S)-3-methyl-2-[(4-nitrophen... 1 1
Peptide deformylase inhibitor N-[(2R,4S)-2-butyl-5-methyl-3-ox... 2 0
Cathepsin K inhibitor AGN-PC-075F1H family 2 0
Aminopeptidase N inhibitor (2S)-2-[(2-chlorophenyl)carbamoylam... 1 1
Gastrin/cholecystokinin type B receptor ligand 2-[5-cyclohexyl... 2 1
E3 ubiquitin-protein ligase XIAP inhibitor (2S)-N-[(2S)-1-[(2S... 1 0
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00378167 CHEMBL2372969 Bioactive (2S)-1-[(2S)-3-methyl-2-(phenylcarbamoylamino)butanoyl]-N-[(3S)-1,1,1-trifluoro-4-methyl-2-oxopentan-3-yl]pyrrolidine-2-carboxamide
CFAMM00378165 CHEMBL1651355 Bioactive 1-[(2S)-1-[[cyano(methyl)amino]-methylamino]-4-methyl-1-oxopentan-2-yl]-3-phenylurea

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27634 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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