CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

Family Name Adenosine receptor A3 and Adenosine receptor A1 ligand propyl 4,6-diethyl-5-ethylsulfanylcarbonyl-2-phenylpyridine-3-carboxylate family
No. of Seeds 6 No. of Other Members 63
Family Centroid CFAMM00314723 Functional Category Bioactive with Human Metabolite & Natural Product
Superfamily Adenosine receptor A3 and Adenosine receptor A1 ligand propyl 4,6-diethyl-5-ethylsulfanylcarbonyl-2-phenylpyridine-3-carboxylate Superfamily
Class Class 2882

Cousin Family NamesSeedsMembers
Dihydroorotate dehydrogenase Inhibitor Brequinar Family 9 122
Retinoic acid receptor alpha Ligand LG100268 Family 2 33
Dipeptidyl peptidase 4 Inhibitor TAK-100 Family 5 7
Metabotropic glutamate receptor 1 Ligand JNJ-16259685 Family 3 20
Metabotropic glutamate receptor 5 Ligand 6-phenylethynyl-nicot... 2 26
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 10 4
Voltage-dependent L-type calcium channel subunit alpha-1C and ... 1 9
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand [(4R,... 3 7
Alpha-1A adrenergic receptor and Voltage-dependent L-type calc... 2 2
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 2 inhibitor AG... 1 0
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 9 6
Pyridines and Derivatives Metabolite Thiazopyr Family 1 6
2-methyl-5-oxo-1,6-naphthyridine-3-carboxylate NP Methyl 6-(2-... 7 0


External ID

Functional Category

Molecule Name

CFAMM00314724 CHEMBL164321 Bioactive AGN-PC-0DAAV3
CFAMM00314723 CHEMBL111086 Bioactive propyl 4,6-diethyl-5-ethylsulfanylcarbonyl-2-phenylpyridine-3-carboxylate
CFAMM00314662 CHEMBL437685 Bioactive dipropyl 2-(3-chlorophenyl)-4,6-diethylpyridine-3,5-dicarboxylate
CFAMM00314681 CHEMBL210351 Bioactive 3-O-ethyl 5-O-propyl 2,4-diethyl-6-phenylpyridine-3,5-dicarboxylate
CFAMM00314720 CHEMBL108705 Bioactive propyl 2-(3-chlorophenyl)-4,6-diethyl-5-propylsulfanylcarbonylpyridine-3-carboxylate
CFAMM00314666 CHEMBL422184 Bioactive 3-fluoropropyl 6-ethyl-5-ethylsulfanylcarbonyl-2-phenyl-4-propylpyridine-3-carboxylate

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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