CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM7236
Family Name Ceramide glucosyltransferase inhibitor AGN-PC-07YS0C family
No. of Seeds 4 No. of Other Members 3
Family Centroid CFAMM00378374 Functional Category Bioactive with Natural Product
Superfamily Coagulation factor X and Ceramide glucosyltransferase Binder Superfamily
Class Class 1033

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 14 2769
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 4 171
Glutamate dehydrogenase inhibitor quinoline derivative Chloroq... 7 189
HIV protease Inhibitor Saquinavir Family 64 428
D(1A) dopamine receptor ligand ergot alkaloid Methylergonovine... 22 170
D(2) dopamine receptor ligand ergot alkaloid Cabergoline Family 5 74
Gastrin/cholecystokinin type B receptor ligand peptide Pentaga... 26 1171
Somatostatin receptor type 2 ligand octapeptide Octreotide Family 27 172
D(2) dopamine receptor Ligand Sertindole Family 3 173
Gamma-aminobutyric acid A receptor Ligand Bromazepam Family 2 60
Indoleamine 2,3-dioxygenase 1 Inhibitor L-tryptophan Family 8 328
Bacterial outer membrane Inhibitor Daptomycin Family 6 50
Somatostatin receptor type 2 ligand octapeptide Lanreotide Family 93 156
Prothrombin Inhibitor Ximelegatran Family 8 157
Transient receptor potential cation channel subfamily V member... 15 158
Hepatocyte growth factor receptor Ligand Arq 197 Family 10 400
Transient receptor potential cation channel subfamily V member... 16 295
Histidine decarboxylase Inhibitor Bf-derm1 Family 12 95
Glycogen synthase kinase-3 beta and Protein kinase C beta type... 5 53
Glycogen phosphorylase, muscle form Inhibitor PSN357 Family 3 253
Substance-P receptor Ligand GSK424887 Family 8 184
Poly [ADP-ribose] polymerase 1 Inhibitor AG-14699 Family 13 179
Reverse transcriptase Inhibitor IDX899 Family 2 118
Growth hormone receptor Ligand EP-51216 Family 34 390
D(1B) dopamine receptor Ligand LE-300 Family 65 452
Histone deacetylase 1 Inhibitor Panobinostat Family 5 93
D(3) dopamine receptor Ligand SB-277011 Family 13 178
Protein kinase C alpha type and Protein kinase C beta type Inh... 16 86
Amg 423 family 7 47
RAC-gamma serine/threonine-protein kinase Inhibitor AZD5363 Fa... 35 69
ABC294640 family 5 75
TGF-beta receptor type-1 Ligand LY2157299 Family 13 56
Gonadotropin-releasing hormone Inhibitor ASP3550 Family 33 60
Gastrin/cholecystokinin type B receptor Ligand PD136450 Family 53 117
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
5-hydroxytryptamine receptor 2A Ligand RP-68303 Family 7 44
Lethal factor Inhibitor GM6001 Family 50 435
cGMP-dependent 3',5'-cyclic phosphodiesterase Inhibitor CP-461... 4 34
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 1-(9h-... 4 25
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 6 17
Fibroblast growth factor receptor 2 Ligand Interferon Alfa (if... 14 162
Somatostatin receptor type 2 Ligand L-054852 Family 13 88
D(4) dopamine receptor Ligand L-745,870 Family 30 205
Inhibitor of nuclear factor kappa-B kinase subunit epsilon and... 1 4
5-hydroxytryptamine receptor 2B Ligand Sb 206553 Family 14 21
Histamine H3 receptor Ligand SCH79687 Family 11 29
Carbonic anhydrase 2 Inhibitor N-[2-(1h-indol-5-yl)-butyl]-4-s... 12 70
D(2) dopamine receptor and D(3) dopamine receptor Ligand 4-(4-... 6 48
Substance-K receptor and Substance-P receptor Ligand L-732138 ... 8 147
Cathepsin B and Cathepsin K Inhibitor Z-arg-leu-val-agly-ile-v... 3 19
D(2) dopamine receptor and D(3) dopamine receptor Ligand L-741... 9 73
Potassium voltage-gated channel subfamily H member 2 Ligand 5-... 5 14
cGMP-inhibited 3',5'-cyclic phosphodiesterase A and Cytochrome... 9 40
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 93
Gonadotropin-releasing hormone receptor Ligand Azaline B Family 12 0
Acetylcholinesterase and Cholinesterase Inhibitor Lipocrine Fa... 18 36
Poly [ADP-ribose] polymerase 1 Inhibitor 1,7,8,9-tetrahydro-1,... 19 64
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[n... 12 10
Melanocortin receptor Ligand Ac-his-dnal(2)-arg-trp-nh2 Family 112 67
Cholecystokinin receptor type A Ligand VL-0395 Family 12 117
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand Ac-... 38 60
Gonadotropin-releasing hormone receptor Ligand [d-ncy(methyl)4... 32 0
Cholinesterase Inhibitor 9-[9-(beta-carboline-9-yl)nonyl]-beta... 7 7
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[c... 20 18
14-alpha sterol demethylase Inhibitor CP-320626 Family 13 76
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 4 33
5-hydroxytryptamine receptor 2C Ligand Cyclo[(6-bromotryptopha... 3 17
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 5-... 4 10
Bifunctional epoxide hydrolase 2 Inhibitor N-(3,3-diphenyl-pro... 6 14
Angiotensin-converting enzyme and Endothelin-converting enzyme... 2 10
Kappa-type opioid receptor and Mu-type opioid receptor Ligand ... 19 108
Adenosine receptor A3 and Potassium voltage-gated channel subf... 1 18
Sodium channel protein type 10 subunit alpha Ligand N-benzyl-5... 11 46
Sodium-dependent serotonin transporter Inhibitor 3-(3-aminocyc... 94 23
Ribosyldihydronicotinamide dehydrogenase [quinone] Inhibitor N... 6 10
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 3-chlo... 3 2
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 3 29
Endothelin B receptor Ligand IRL-2500 Family 34 87
Vasopressin V1a receptor and Vasopressin V1b receptor Ligand D... 10 19
Amine oxidase [flavin-containing] A Inhibitor N-benzyl-1h-pyrr... 12 46
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 12 72
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 18 72
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Acetylcholinesterase and Cholinesterase Inhibitor 3-(2-diethyl... 12 160
Melanocortin receptor Ligand Ac-his-dphe(3,4-dicl)-arg-trp-nh2... 10 14
Histone deacetylase Inhibitor ST-5732 Family 8 6
Bombesin receptor subtype-3 and Gastrin-releasing peptide rece... 42 7
Acetylcholinesterase and Cholinesterase Inhibitor Huprine-tacr... 62 27
Substance-K receptor ligand 1-N,2-N-bis[2-(1H-indol-3-yl)ethyl... 1 0
Substance-P receptor ligand AGN-PC-01ZIXQ family 13 42
Huntingtin and Glycogen synthase kinase-3 beta inhibitor SB 21... 2 4
Prothrombin inhibitor SureCN5856722 family 3 16
C-C chemokine receptor type 5 ligand AC1LAJEM family 4 14
Pol polyprotein inhibitor penicillin deriv. 40 family 2 4
RAC-alpha serine/threonine-protein kinase and Cyclin-dependent... 3 7
Vasopressin V2 receptor and Vasopressin V1a receptor ligand [2... 2 5
Acetylcholinesterase inhibitor AGN-PC-07ZG1K family 3 0
Gonadotropin-releasing hormone receptor ligand 1-(3-azabicyclo... 6 2
Gonadotropin-releasing hormone receptor ligand 5-[2-[[(2S)-2-[... 7 58
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 17 28
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 14 8
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 1
Cathepsin L1 inhibitor Bio2_000267 family 9 1
Neutrophil collagenase and Stromelysin-3 inhibitor AC1MORIH fa... 7 9
Growth hormone secretagogue receptor type 1 ligand 2-amino-N-[... 1 0
Growth hormone secretagogue receptor type 1 ligand 2-amino-N-[... 3 0
Adenosine kinase inhibitor 5-(4-chlorophenyl)-6-[2-(6-morpholi... 8 8
Cannabinoid receptor 1 ligand AGN-PC-04YSUM family 7 6
Dipeptidyl peptidase 9 and Dipeptidyl peptidase 8 inhibitor Su... 16 5
Histamine H3 receptor and Cytochrome P450 3A4 ligand AGN-PC-08... 15 5
Vasopressin V1b receptor ligand 2-[3-(3-chlorophenyl)-1-oxo-7-... 2 12
Prothrombin inhibitor (2S)-N-[(6-carbamimidoylpyridin-3-yl)met... 2 14
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 11 20
MAP kinase-activated protein kinase 2 and Mitogen-activated pr... 5 2
P2X purinoceptor 7 inhibitor (4S)-N-[[2-chloro-3-(trifluoromet... 9 31
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 13 1
Cathepsin K inhibitor SureCN2155973 family 3 1
Melanin-concentrating hormone receptor 1 ligand AGN-PC-072CVE ... 4 4
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 0
Translocator protein inhibitor (2E)-N-(4-chlorophenyl)-N-methy... 2 13
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 2 0
D(4) dopamine receptor and D(1A) dopamine receptor ligand 2-[[... 5 4
5-hydroxytryptamine receptor 1A ligand 2-[4-(quinolin-2-ylmeth... 2 91
Melatonin receptor type 1A and Melatonin receptor type 1C liga... 2 5
Dihydroorotate dehydrogenase (quinone), mitochondrial inhibito... 2 21
Growth hormone-releasing hormone receptor ligand ethyl (1S)-1'... 3 2
Somatostatin receptor type 2 ligand (2R,3S)-N-[(5-amino-1,3-di... 2 5
Survival motor neuron protein and Menin inhibitor CHEMBL151109... 1 11
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 5 8
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 3 0
Somatostatin receptor type 4 ligand methyl 5-(diaminomethylide... 2 34
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 2 4
Neuropeptide Y receptor type 5 ligand 2-(6-chloroindol-1-yl)-N... 4 23
Coagulation factor X inhibitor AGN-PC-00FNCN family 3 3
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 2
Prothrombin and Trypsin-1 inhibitor 2-[6-methyl-2-oxo-3-(2-pyr... 4 2
Glucocorticoid receptor and Mineralocorticoid receptor ligand ... 9 3
Dipeptidyl peptidase 4 inhibitor (2S)-1-[2-[5-(aminomethyl)-2-... 4 4
cGMP-specific 3',5'-cyclic phosphodiesterase and Dual 3',5'-cy... 4 129
Acetylcholinesterase inhibitor CHEMBL1651131 family 6 9
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor 2-... 18 2
Substance-P receptor ligand N-[(2S)-5-[3,5-bis(trifluoromethyl... 4 6
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 3 2
Glucocorticoid receptor and Androgen receptor ligand AGN-PC-0A... 3 0
Substance-P receptor and Neuromedin-K receptor ligand SureCN88... 4 14
Histone deacetylase and Histone deacetylase 3 inhibitor (3S,6R... 2 2
Renin and Potassium voltage-gated channel subfamily H member 2... 9 2
Metabotropic glutamate receptor 5 ligand [2-[6-(3-chlorophenyl... 1 1
C-X-C chemokine receptor type 3 ligand (6aR,9R)-N-phenyl-4-(2-... 5 0
Smoothened homolog inhibitor (8aS)-N-[2-(3-cyanophenyl)pyridin... 3 4
Coagulation factor X and Prothrombin inhibitor 2-carboxyindole... 2 8
Cannabinoid receptor 2 ligand 1-[[4-[5-fluoro-6-(piperidin-1-y... 21 2
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 1
CGMP-dependent protein kinase inhibitor AGN-PC-075XII family 25 7
Substance-P receptor and Neuromedin-K receptor ligand 2-[3,5-b... 7 0
Melanin-concentrating hormone receptor 2 ligand N-[(1R)-1'-(9H... 4 1
C-C chemokine receptor type 3 ligand 1-[(1R,2S)-2-[[3-[(4-fluo... 3 2
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-009GH... 8 10
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 10 0
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 3 1
Neuropeptide Y receptor type 5 ligand 2-indol-1-yl-N-[4-[(prop... 7 6
Substance-P receptor ligand [3,5-bis(trifluoromethyl)phenyl]-[... 17 1
Melanin-concentrating hormone receptor 1 and 5-hydroxytryptami... 2 0
Oxytocin receptor ligand (3R,6R)-3-(2,3-dihydro-1H-inden-2-yl)... 20 2
Egl nine homolog 1 inhibitor 1'-[(3-methylpyridin-2-yl)methyl]... 6 4
Dipeptidyl peptidase 4 inhibitor [(2S,4S)-4-(4-quinolin-4-ylpi... 5 8
Cathepsin K and Cathepsin S inhibitor (2S)-N-(cyanomethyl)-4-m... 1 0
Cathepsin K inhibitor (1R,2R)-2-(6-chloro-1,3,4,5-tetrahydropy... 2 0
Cathepsin K and Cathepsin B inhibitor (1R,2R)-N-(1-cyanocyclop... 10 7
Probable G-protein coupled receptor 142 ligand (2S)-N-(2-oxo-5... 2 1
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 3 2
Renin inhibitor (E)-but-2-enedioic acid;(3S,5R)-5-[4-(2-chloro... 6 8
Dual specificity protein kinase CLK4 and Mitogen-activated pro... 1 1
Coagulation factor X and Prothrombin inhibitor SureCN8243313 f... 10 8
Coagulation factor X and Prothrombin inhibitor SureCN8237487 f... 16 1
RAC-beta serine/threonine-protein kinase and 3-phosphoinositid... 11 4
Coagulation factor X inhibitor 3-chloro-N-[(1S,2S)-2-[[4-(2-ox... 22 3
Gonadotropin-releasing hormone receptor ligand 1-adamantyl-[2-... 3 1
Translocator protein inhibitor CHEMBL2331870 family 2 0
Disintegrin and metalloproteinase domain-containing protein 17... 7 9
C-C chemokine receptor type 2 ligand SureCN5946889 family 2 6
Coagulation factor X inhibitor ethyl (3R,4S)-3-[(3-chloro-1H-i... 5 0
C-C chemokine receptor type 2 ligand 2-[4-(5-amino-1H-indol-3-... 3 2
Seprase and Prolyl endopeptidase inhibitor 7-chloro-N-[2-[(2S)... 3 3
Gonadotropin-releasing hormone receptor ligand SureCN7899418 f... 12 4
C-C chemokine receptor type 1 ligand N-[(2R)-1-[4-(4-chlorophe... 2 1
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 3 0
Orexin receptor type 2 and Orexin receptor type 1 ligand 9-(4,... 2 8
C-C chemokine receptor type 5 ligand 6-chloro-N-[(3R)-3-[4-[(5... 16 4
Dipeptidyl peptidase 9 and Dipeptidyl peptidase 8 inhibitor 3-... 17 0
3-oxo-5-alpha-steroid 4-dehydrogenase 2 and 3-oxo-5-alpha-ster... 2 1
Phospholipase D1 and Phospholipase D2 inhibitor SureCN10311349... 2 14
Histone deacetylase 1 inhibitor (2S)-N'-hydroxy-2-(pyridine-2-... 3 0
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor (2... 2 2
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 2 18
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 3 5
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 3 8
C-C chemokine receptor type 2 ligand SureCN5947024 family 11 0
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 4 11
CGMP-dependent protein kinase inhibitor methyl 2-[[4-[5-(4-flu... 6 1
C-C chemokine receptor type 2 ligand (E)-3-(3,4-dichlorophenyl... 3 2
Proteinase-activated receptor 1 and Prothrombin ligand (2S)-N-... 3 23
CGMP-dependent protein kinase inhibitor 1-[4-acetyl-3-[[4-[5-(... 2 0
Endothelin B receptor and Endothelin-1 receptor ligand 2-[[(2R... 17 10
Bombesin receptor subtype-3 ligand SureCN13887096 family 3 1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 2
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 2 2
Platelet-activating factor receptor ligand (4R)-N-(3-benzoylph... 2 1
Neuromedin-B receptor and Gastrin-releasing peptide receptor l... 6 4
Stromelysin-3 and Neutrophil collagenase inhibitor AGN-PC-074N... 3 1
Neuromedin-B receptor and Gastrin-releasing peptide receptor l... 2 0
Substance-P receptor and Substance-K receptor ligand N-methyl-... 2 2
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 2 2
Growth factor receptor-bound protein 2 ligand [4-[(2S)-2-aceta... 5 2
Chymase inhibitor SureCN408571 family 1 3
KiSS-1 receptor ligand SureCN5132924 family 2 4
Gonadotropin-releasing hormone receptor ligand 1-[2-(3,5-dimet... 2 0
Coagulation factor X and Prothrombin inhibitor N,1-bis[(3-carb... 1 1
Poly [ADP-ribose] polymerase 1 inhibitor SureCN4998361 family 1 1
Somatostatin receptor type 4 and Somatostatin receptor type 5 ... 3 4
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 5 0
Translocator protein inhibitor N,N-dibutyl-2-(7-chloro-2-pheny... 3 1
Nociceptin receptor and Mu-type opioid receptor ligand (1R,5R)... 4 17
Nociceptin receptor and Mu-type opioid receptor ligand N-[(1R,... 4 2
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 3 4
P2X purinoceptor 7 inhibitor N-[1-[(Z)-[(cyanoamino)-(quinolin... 3 3
Neuropeptide Y receptor type 5 ligand 1-methylsulfonyl-N-(4-py... 9 0
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 2 1
Matrix metalloproteinase-9 and 72 kDa type IV collagenase inhi... 2 4
Translocator protein inhibitor 2-(7-Chloro-5-methyl-4-oxo-3-ph... 1 0
Melanin-concentrating hormone receptor 1 ligand SureCN4917950 ... 3 5
5-hydroxytryptamine receptor 7 ligand AGN-PC-00PFK0 family 1 0
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 6 4
Metabotropic glutamate receptor 5 ligand [2-[6-(3-chlorophenyl... 1 2
Integrin beta-2 and Intercellular adhesion molecule 1 inhibito... 2 2
Glucocorticoid receptor ligand 5-[(6-methylpyridin-2-yl)methyl... 3 0
P2X purinoceptor 7 inhibitor AGN-PC-088FRW family 2 4
D(2) dopamine receptor and D(3) dopamine receptor ligand methy... 2 1
Receptor-interacting serine/threonine-protein kinase 1 ligand ... 1 11
Melanin-concentrating hormone receptor 1 ligand SureCN13918021... 1 0
Tyrosine-protein kinase inhibitor (4-chloro-1H-indol-2-yl)-[(3... 1 0
Tyrosine-protein kinase JAK3 inhibitor (3Z)-5-pyridin-3-yl-3-(... 1 0
Proto-oncogene Wnt-3 inhibitor CHEMBL563202 family 2 0
2,3,6,7-tetrahydropyrazino[1',2':1,2]pyrido[3,4-b]indole-1,4(1... 3 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00378370 CHEMBL423623 Bioactive AGN-PC-00OMUN
CFAMM00378374 CHEMBL2163821 Bioactive AGN-PC-07YS0C
CFAMM00378373 CHEMBL2163829 Bioactive 1-(2,4-dichlorophenyl)-N-[(2S)-3-(1H-indol-3-yl)-1-(4-methylpiperazin-1-yl)-1-oxopropan-2-yl]cyclopropane-1-carboxamide
CFAMM00378372 CHEMBL165498 Bioactive N-[1-[acetyl-[(2-chlorophenyl)methyl]amino]-3-(1H-indol-3-yl)propan-2-yl]-2-(4-phenylpiperazin-1-yl)acetamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27295 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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