CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM7246
Family Name Thymidylate synthase inhibitor (2S)-2-[[(4S)-4-carboxy-4-[[(4S)-4-carboxy-4-[[5-[methyl-[(2-methyl-4-oxo-1H-quinazolin-6-yl)methyl]amino]thiophene-2-carbonyl]amino]butanoyl]amino]butanoyl]amino]pentanedioic acid family
No. of Seeds 7 No. of Other Members 11
Family Centroid CFAMM00378430 Functional Category Bioactive
Superfamily Huntingtin and Thymidylate synthase Binder Superfamily
Class Class 4044

Cousin Family NamesSeedsMembers
Thymidylate synthase inhibitor (2S)-2-[[4-[(2-methyl-4-oxo-1,6... 15 107
Thymidylate synthase inhibitor AC1LABAB family 14 3
Thymidylate synthase inhibitor (2R)-2-[[(4S)-4-carboxy-4-[[4-[... 55 43
Trifunctional purine biosynthetic protein adenosine-3 inhibito... 4 11
Thymidylate synthase inhibitor AC1LAB82 family 17 0
Thymidylate synthase inhibitor AC1LAB7Z family 8 3
Dihydrofolate reductase and Thymidylate synthase inhibitor 2-[... 10 5
Dihydrofolate reductase inhibitor 2-[[4-carboxy-4-[[4-[(2,4-di... 3 1
Trifunctional purine biosynthetic protein adenosine-3 inhibito... 4 1
Folylpolyglutamate synthase, mitochondrial and Dihydrofolate r... 3 0
Dihydrofolate reductase inhibitor 2-[[4-[2-(2-amino-4-oxo-1,5,... 2 0
Thymidylate synthase inhibitor SureCN6446340 family 2 1
Cationic trypsin and Prothrombin inhibitor 2-ketobenzothiazole... 1 3
Trifunctional purine biosynthetic protein adenosine-3 inhibito... 1 0
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00378439 CHEMBL268593 Bioactive (2S)-2-[[(4S)-4-carboxy-4-[[(4S)-4-carboxy-4-[[(4S)-4-carboxy-4-[[(4S)-4-carboxy-4-[[5-[methyl-[(2-methyl-4-oxo-1H-quinazolin-6-yl)methyl]amino]thiophene-2-carbonyl]amino]butanoyl]amino]butanoyl]amino]butanoyl]amino]butanoyl]amino]pentanedioic acid
CFAMM00378425 CHEMBL166027 Bioactive (2R)-2-[[4-[(2-amino-6-methyl-4-oxo-1H-quinazolin-5-yl)sulfanyl]benzoyl]amino]pentanedioic acid
CFAMM00378437 CHEMBL169506 Bioactive SureCN7509942
CFAMM00378430 CHEMBL355321 Bioactive (2S)-2-[[(4S)-4-carboxy-4-[[(4S)-4-carboxy-4-[[5-[methyl-[(2-methyl-4-oxo-1H-quinazolin-6-yl)methyl]amino]thiophene-2-carbonyl]amino]butanoyl]amino]butanoyl]amino]pentanedioic acid
CFAMM00378428 CHEMBL405513 Bioactive (2S)-2-[[(4S)-4-carboxy-4-[[(4S)-4-carboxy-4-[[(4S)-4-carboxy-4-[[(4S)-4-carboxy-4-[[(4S)-4-carboxy-4-[[5-[methyl-[(2-methyl-4-oxo-1H-quinazolin-6-yl)methyl]amino]thiophene-2-carbonyl]amino]butanoyl]amino]butanoyl]amino]butanoyl]amino]butanoyl]amino]butanoyl]amino]pentanedioic acid
CFAMM00378427 CHEMBL172160 Bioactive (2S)-2-[[(4S)-4-carboxy-4-[[(4S)-4-carboxy-4-[[(4S)-4-carboxy-4-[[5-[methyl-[(2-methyl-4-oxo-1H-quinazolin-6-yl)methyl]amino]thiophene-2-carbonyl]amino]butanoyl]amino]butanoyl]amino]butanoyl]amino]pentanedioic acid
CFAMM00378440 CHEMBL166369 Bioactive (2R)-2-[[4-[(2,6-dimethyl-4-oxo-1H-quinazolin-5-yl)sulfanyl]benzoyl]amino]pentanedioic acid

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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