CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM7247
Family Name Corticotropin-releasing factor receptor 1 ligand 2-[butyl-[4-[4-(dimethylamino)-N-ethyl-2-(trifluoromethyl)anilino]-6-methyl-1,3,5-triazin-2-yl]amino]acetonitrile family
No. of Seeds 9 No. of Other Members 9
Family Centroid CFAMM00378461 Functional Category Bioactive
Superfamily Papain and Cruzipain Binder Superfamily 2
Class Class 4537

Cousin Family NamesSeedsMembers
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 8 55
Cyclin-dependent kinase 2 and Mitogen-activated protein kinase... 7 30
Cathepsin K Inhibitor 4-phenyl-6-propylpyrimidine-2-carbonitri... 6 10
Macrophage migration inhibitory factor Inhibitor 4-iodo-6-phen... 5 4
Oestrogen receptor Ligand 4-benzyl-2,6-diisobutylamino-pyrimid... 5 37
Cruzipain and Cathepsin K inhibitor AGN-PC-076IFJ family 3 3
Corticotropin-releasing factor receptor 1 ligand 2-N-butyl-4-N... 3 0
Cell division cycle 7-related protein kinase inhibitor CHEMBL1... 1 2
Cruzipain and Papain inhibitor AGN-PC-076IFM family 1 1


External ID

Functional Category

Molecule Name

CFAMM00378456 CHEMBL422555 Bioactive 3-[butyl-[4-[4-(dimethylamino)-N-ethyl-2-methylanilino]-6-methyl-1,3,5-triazin-2-yl]amino]propanenitrile
CFAMM00378449 CHEMBL167095 Bioactive 3-[[4-[4-(dimethylamino)-N-ethyl-2-methylanilino]-6-methyl-1,3,5-triazin-2-yl]-propylamino]propanenitrile
CFAMM00378454 CHEMBL354178 Bioactive 3-[[4-[4-(dimethylamino)-N-ethyl-2-(trifluoromethyl)anilino]-6-methyl-1,3,5-triazin-2-yl]-propylamino]propanenitrile
CFAMM00378463 CHEMBL167428 Bioactive 2-N-(cyclopropylmethyl)-4-N-[4-(dimethylamino)-2-(trifluoromethyl)phenyl]-4-N-ethyl-6-methyl-2-N-propyl-1,3,5-triazine-2,4-diamine
CFAMM00378447 CHEMBL442773 Bioactive 2-[butyl-[4-[4-(dimethylamino)-N-ethyl-2-methylanilino]-6-methyl-1,3,5-triazin-2-yl]amino]acetonitrile
CFAMM00378453 CHEMBL354395 Bioactive 2-N,2-N-bis(cyclopropylmethyl)-4-N-[4-(dimethylamino)-2-(trifluoromethyl)phenyl]-4-N-ethyl-6-methyl-1,3,5-triazine-2,4-diamine
CFAMM00378461 CHEMBL166056 Bioactive 2-[butyl-[4-[4-(dimethylamino)-N-ethyl-2-(trifluoromethyl)anilino]-6-methyl-1,3,5-triazin-2-yl]amino]acetonitrile
CFAMM00378452 CHEMBL168169 Bioactive 4-N-[4-(dimethylamino)-2-methylphenyl]-4-N-ethyl-6-methyl-2-N,2-N-dipropyl-1,3,5-triazine-2,4-diamine
CFAMM00378451 CHEMBL168497 Bioactive 4-N-[4-(dimethylamino)-2-(trifluoromethyl)phenyl]-4-N-ethyl-6-methyl-2-N,2-N-dipropyl-1,3,5-triazine-2,4-diamine

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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