CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM7258
Family Name Proto-oncogene tyrosine-protein kinase Src and Epidermal growth factor receptor ligand SureCN7018784 family
No. of Seeds 9 No. of Other Members 9
Family Centroid CFAMM00144952 Functional Category Bioactive
Superfamily Proto-oncogene tyrosine-protein kinase Src and Epidermal growth factor receptor Binder Superfamily
Class Class 227

Cousin Family NamesSeedsMembers
Histamine H1 receptor Ligand Astemizole Family 7 240
Peptide deformylase, mitochondrial Inhibitor Trimethoprim Family 67 482
Corticotropin-releasing factor receptor 1 Ligand CRF-1 Antagon... 29 421
Hypoxia-inducible factor 1-alpha Inhibitor Hif-1alpha Family 7 107
Cyclin-dependent kinase 2 Inhibitor Seliciclib Family 29 292
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 13
Insulin-like growth factor 1 receptor Ligand AEW-541 Family 12 140
Corticotropin-releasing factor receptor 1 Ligand GW876008 Family 3 30
Adenosine receptor A1 Ligand SLV320 Family 6 79
Ibrutinib family 2 27
Peptide deformylase, mitochondrial Inhibitor Epiroprim Family 5 68
Tyrosine kinase Inhibitor PKI166 Family 17 198
Heat shock protein HSP 90-alpha Inhibitor 8-benzo[1,3]dioxol-,... 5 83
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 9 Inhibi... 10 35
Vascular endothelial growth factor receptor 2 Ligand L00002164... 6 23
Glycogen synthase kinase-3 beta and Mitogen-activated protein ... 8 8
Adenosine receptor A1 and Adenosine receptor A2a Ligand N6-met... 21 57
Serine/threonine-protein kinase mTOR Inhibitor (4-(6-morpholin... 2 11
AMP-activated protein kinase Inhibitor 4-(3-bromopyrazolo[1,5-... 1 8
Adenosine kinase inhibitor GP683 family 12 7
Adenosine receptor A1 and Adenosine receptor A2a ligand NSC658... 8 54
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 3 4
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 6 35
Serine/threonine-protein kinase B-raf inhibitor SureCN1015955 ... 17 18
Serine/threonine-protein kinase B-raf inhibitor AGN-PC-072YMN ... 7 11
Serine/threonine-protein kinase B-raf inhibitor 3-[7-[4-[[(3R)... 6 7
Proto-oncogene tyrosine-protein kinase Src and Cyclin-dependen... 2 1
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 6
Serine/threonine-protein kinase Chk2 and Serine/threonine-prot... 3 6
Proto-oncogene tyrosine-protein kinase Src and Tyrosine-protei... 12 8
Dihydrofolate reductase inhibitor AC1LA5HU family 8 4
Adenosine receptor A1 and Adenosine receptor A2a ligand (6E)-6... 2 2
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 6 13
Cellular tumor antigen p53 and Lysosomal alpha-glucosidase inh... 1 6
Lethal factor and Dual specificity protein kinase CLK4 inhibit... 1 3
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 2
Integrin beta-1 and Integrin alpha-4 inhibitor SureCN2059024 f... 6 3
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 17
Proto-oncogene tyrosine-protein kinase Src inhibitor ethyl 2-[... 4 9
Hepatocyte growth factor receptor ligand 4-[(6-phenyl-[1,2,4]t... 3 6
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 2 1
Adenosine kinase inhibitor (2R,3R,4R)-2-[4-(2,3-dihydro-1,4-be... 5 2
Adenosine kinase inhibitor 2-[[7-[(2R,3R,4S,5R)-3,4-dihydroxy-... 15 0
Rho-associated protein kinase 1 and cAMP-dependent protein kin... 1 11
Vascular endothelial growth factor receptor 2 and Vascular end... 4 2
Lysine--tRNA ligase inhibitor 4-[[[2-(2-piperazin-1-ylpyridin-... 2 1
Activated CDC42 kinase 1 inhibitor 5-(2-fluorophenyl)-N-[[(2S)... 5 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 1
Eukaryotic translation initiation factor 2-alpha kinase 3 inhi... 1 1
Cathepsin K and Cathepsin L1 inhibitor 2-Cyano-pyrimidine, 17a... 5 8
Tyrosine-protein kinase Lck inhibitor 3-[[2-(benzimidazol-1-yl... 2 0
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 3 14
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 5
Histone-arginine methyltransferase CARM1 inhibitor AGN-PC-00HE... 4 4
Tyrosine-protein kinase JAK2 inhibitor (2R)-2-[4-[[8-(4-methox... 2 0
Cathepsin K and Cathepsin S inhibitor SureCN4135077 family 2 0
Transient receptor potential cation channel subfamily V member... 1 4
Dihydrofolate reductase inhibitor AC1LAPW3 family 3 0
Dihydrofolate reductase and Dihydrofolate reductase type 1 inh... 8 1
Tyrosine-protein kinase Lck and Vascular endothelial growth fa... 1 0
Cathepsin S and Cathepsin K inhibitor AGN-PC-078ZDC family 4 2
Tyrosine-protein kinase Lck and Vascular endothelial growth fa... 1 0
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 1 0
Serine/threonine-protein kinase Chk2 inhibitor (6E)-4-fluoro-6... 3 6
Glucose-dependent insulinotropic receptor ligand tert-butyl 4-... 1 1
Tyrosine-protein kinase Lck and Angiopoietin-1 receptor ligand... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name


Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27395 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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