CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM7273
Family Name Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform and Serine/threonine-protein kinase mTOR inhibitor AGN-PC-08Y2XC family
No. of Seeds 2 No. of Other Members 2
Family Centroid CFAMM00330887 Functional Category Bioactive
Superfamily Serine/threonine-protein kinase PLK1 Inhibitor Bi 6727 Superfamily
Class Class 850

Cousin Family NamesSeedsMembers
Mast/stem cell growth factor receptor Kit and Abelson tyrosine... 6 537
Reverse transcriptase Inhibitor Nevirapine Family 23 640
Prothrombin Inhibitor Dabigatran Family 7 182
Serine/threonine-protein kinase PLK1 Inhibitor Bi 6727 Family 15 81
Gamma-secretase subunit APH-1B Inhibitor E2012 Family 3 67
Receptor tyrosine-protein kinase erbB-2 Inhibitor CP-724714 Fa... 4 180
Dipeptidyl peptidase 4 Inhibitor Linagliptin Family 10 81
Mast/stem cell growth factor receptor Kit and Vascular endothe... 4 47
Protein kinase C alpha type and Protein kinase C beta type Inh... 16 86
Smoothened homolog Inhibitor LDE225 Family 3 76
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 11 10
Histone deacetylase 6 Inhibitor ACY-1215 Family 10 230
MK-6096 family 3 69
JAK Inhibitor Momelotinib Family 33 83
XL-888 family 16 85
5-hydroxytryptamine receptor 1A Ligand P-MPPI Family 33 81
Epidermal growth factor receptor Ligand PD-158780 Family 98 89
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 19 103
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
C-X-C chemokine receptor type 3 Ligand AMG-487 Family 28 73
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 4 6
Potassium voltage-gated channel subfamily H member 2 Ligand Be... 22 56
Adenosine receptor A1 and Adenosine receptor A2a Ligand N-(2-(... 21 108
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 2 3
Reverse transcriptase Inhibitor Atevirdine Family 4 55
Reverse transcriptase Inhibitor UK-129485 Family 23 221
Glutamate receptor 1 Ligand Piriqualone Family 8 67
Metabotropic glutamate receptor 5 Ligand 3-methoxy-n-(6-methyl... 3 15
Liver carboxylesterase 1 Inhibitor SM-32504 Family 3 28
Reverse transcriptase/RNaseH inhibitor AC1LALKM family 2 19
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 8 12
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 6 35
Tyrosine-protein kinase JAK3 and Tyrosine-protein kinase JAK2 ... 1 11
Orexin receptor type 2 and Orexin receptor type 1 ligand [(7R)... 10 10
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 6 11
Muscarinic acetylcholine receptor M2 and Muscarinic receptor 3... 4 3
Lysine--tRNA ligase and Dual specificity protein kinase CLK4 i... 4 27
Transient receptor potential cation channel subfamily V member... 1 4
TGF-beta receptor type-1 ligand 6-[4-ethyl-2-(6-methylpyridin-... 9 11
Angiopoietin-1 receptor and Aurora kinase B ligand SureCN12658... 3 19
Glucocorticoid receptor ligand (2R)-1,1,1-trifluoro-4-(2-metho... 2 5
Adenosine receptor A2a ligand SureCN14156209 family 3 2
Cell division cycle 7-related protein kinase inhibitor pyrrolo... 4 10
Adenosine receptor A3 ligand N-(5-methyl-2-phenylpyrazolo[4,3-... 5 8
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 14
Thyroid hormone receptor beta and Ferritin light chain ligand ... 1 35
Reverse transcriptase/RNaseH inhibitor Dipyridodiazepinone der... 1 8
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 5 4
Thyroid hormone receptor beta and Cruzipain ligand CHEMBL14730... 1 12
Dihydrofolate reductase inhibitor AC1LA5HU family 8 4
Dihydrofolate reductase inhibitor AC1L9XPA family 6 5
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 6 13
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 4 11
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 0
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 1 1
ALK tyrosine kinase receptor and Insulin receptor ligand SureC... 7 1
Prostaglandin D2 receptor ligand 1-[3-[2-methoxy-6-[2-(4-metho... 6 16
Prostaglandin D2 receptor ligand 2-methoxy-N-[2-(4-methoxyphen... 2 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 6 12
Calcium/calmodulin-dependent protein kinase kinase 2 and Focal... 3 17
Serine/threonine-protein kinase PLK1 inhibitor AGN-PC-0A9RFQ f... 2 1
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-0A9QGC ... 14 0
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-0A9RSG ... 6 5
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 3 2
Corticotropin-releasing factor receptor 1 ligand Pyridopyrazin... 3 5
Reverse transcriptase/RNaseH and Cytochrome P450 2C19 inhibito... 7 2
Transient receptor potential cation channel subfamily V member... 2 1
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 7 4
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 2
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 2
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 6 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 1
Serine/threonine-protein kinase RIO2 and Serine/threonine-prot... 12 13
MAP kinase-activated protein kinase 2 inhibitor N-[4-(4-oxospi... 3 0
Dipeptidyl peptidase 4 and Cytochrome P450 3A4 inhibitor 6-[(3... 10 0
Interleukin-1 receptor-associated kinase 4 and Interleukin-1 r... 4 0
Insulin-like growth factor 1 receptor ligand GSK1220512A family 20 15
Insulin-like growth factor 1 receptor and Mitogen-activated pr... 3 4
Rho-associated protein kinase 1 and cAMP-dependent protein kin... 1 11
Serine/threonine-protein kinase TBK1 and Inhibitor of nuclear ... 2 8
Vascular endothelial growth factor receptor 2 ligand (3Z)-3-[5... 4 11
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 4 2
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 7 3
Smoothened homolog and Mitogen-activated protein kinase 14 inh... 7 11
Lysine--tRNA ligase inhibitor N-[2-(2-piperazin-1-ylpyridin-4-... 5 0
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 3 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 18 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 1
Angiopoietin-1 receptor and Vascular endothelial growth factor... 4 8
Glycogen synthase kinase-3 beta and Casein kinase I isoform ga... 3 0
Receptor tyrosine-protein kinase erbB-2 ligand SureCN4461871 f... 2 2
Adenosine receptor A2a and Cytochrome P450 3A4 ligand N-[6-(3,... 5 2
G-protein coupled bile acid receptor 1 ligand 2-ethyl-6-[3-[4-... 4 6
Motilin receptor ligand SureCN2765637 family 1 1
Tyrosine-protein kinase ABL1 and Breakpoint cluster region pro... 8 5
Histone-arginine methyltransferase CARM1 inhibitor AGN-PC-00HE... 4 4
Aurora kinase B and Aurora kinase A inhibitor 2-fluoro-6-metho... 2 0
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[2-(die... 12 2
cAMP-specific 3',5'-cyclic phosphodiesterase 4B inhibitor 4-[4... 1 1
Angiopoietin-1 receptor and Vascular endothelial growth factor... 5 0
Tyrosine-protein kinase Lck and Proto-oncogene tyrosine-protei... 3 0
Tyrosine-protein kinase Lck and Mitogen-activated protein kina... 2 1
Dihydrofolate reductase inhibitor AC1LAPW3 family 3 0
Dihydrofolate reductase inhibitor AGN-PC-001U7R family 3 0
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 2
Vasopressin V1a receptor and Vasopressin V2 receptor ligand AG... 2 2
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 6 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 0
Tyrosine-protein kinase Lck and Mitogen-activated protein kina... 2 0
RAF proto-oncogene serine/threonine-protein kinase inhibitor a... 8 6
Insulin-like growth factor 1 receptor and Mitogen-activated pr... 15 1
Epidermal growth factor receptor ligand (E)-5-[4-(3-bromoanili... 11 0
Cyclin-dependent kinase 2 and Potassium voltage-gated channel ... 12 7
Insulin-like growth factor 1 receptor ligand AGN-PC-050GPS family 7 0
Insulin-like growth factor 1 receptor and Mitogen-activated pr... 6 0
Transient receptor potential cation channel subfamily V member... 2 0
Oxytocin receptor and Vasopressin V1a receptor ligand AGN-PC-0... 4 3
Mast/stem cell growth factor receptor Kit and Tyrosine-protein... 4 1
Epidermal growth factor receptor ligand Pyrido[3,4-d]pyrimidin... 3 1
Acyl-CoA desaturase inhibitor SureCN1182546 family 2 5
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 7 6
Poly [ADP-ribose] polymerase 1 and Poly [ADP-ribose] polymeras... 4 0
C-C chemokine receptor type 8 and Potassium voltage-gated chan... 1 3
Vascular endothelial growth factor receptor 2 and Serine/threo... 4 2


CFAM Mol ID

External ID

Functional Category

Molecule Name


Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27038 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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