CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM7294
Family Name Prostaglandin D2 receptor 2 and Prostaglandin D2 receptor ligand 2-[3-[2-[[ethyl(phenylmethoxycarbonyl)amino]methyl]-4-(trifluoromethyl)phenyl]-4-methoxyphenyl]acetic acid family
No. of Seeds 12 No. of Other Members 0
Family Centroid CFAMM00378810 Functional Category Bioactive
Superfamily Prostaglandin D2 receptor 2 and Prostaglandin D2 receptor Binder Superfamily 2
Class Class 4539

Cousin Family NamesSeedsMembers
Cholesteryl ester transfer protein Inhibitor Anacetrapib Family 3 63
C-C chemokine receptor type 2 Ligand CCX915 Family 3 25
Endothelin-1 receptor Ligand Atrasentan Family 127 336
Integrin alpha-4 Inhibitor Firategrast Family 3 93
Sigma non-opioid intracellular receptor 1 Ligand SSR-125047 Fa... 1 2
Microsomal triglyceride transfer protein large subunit Inhibit... 3 103
Guanylate cyclase soluble subunit beta-1 Inhibitor Cinaciguat ... 7 50
Potassium voltage-gated channel subfamily A member 3 Ligand 2-... 9 92
Peroxisome proliferator-activated receptor gamma and Peroxisom... 2 4
Mitogen-activated protein kinase 14 Inhibitor N-(4-(trifluorom... 8 39
Fatty-acid amide hydrolase 1 Inhibitor 3'-carbamoylbiphenyl-3-... 8 50
Squalene synthase Inhibitor 3-[7'-(methoxy)-napht-2'-yl]-quinu... 53 30
Peroxisome proliferator-activated receptor gamma and Peroxisom... 1 0
Peroxisome proliferator-activated receptor delta and Peroxisom... 20 8
Prostaglandin E2 receptor EP3 subtype and Prostaglandin E2 rec... 55 36
Prostaglandin E2 receptor EP3 subtype and Prostaglandin E2 rec... 8 12
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 6 19
Endothelin-1 receptor and Endothelin B receptor ligand (2R,3R,... 3 2
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 10 8
Leukotriene B4 receptor 1 ligand AGN-PC-00GEAR family 2 2
Type-2 angiotensin II receptor ligand SureCN244657 family 7 11
Prostaglandin D2 receptor 2 ligand SureCN137334 family 1 0
Angiotensin-converting enzyme and Angiotensin-converting enzym... 3 13
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 1 28
Prostaglandin E2 receptor EP4 subtype ligand 4-[(1S)-1-[[2-(tr... 2 1
Free fatty acid receptor 1 ligand 3-[4-[[3-[2,6-dimethyl-4-[3-... 1 0
Glucagon receptor and Gastric inhibitory polypeptide receptor ... 1 0
Peroxisome proliferator-activated receptor delta and Peroxisom... 13 0
Beta-3 adrenergic receptor and Beta-1 adrenergic receptor liga... 15 13
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 2 2
Kappa-type opioid receptor ligand N-[(1S)-2-[(3S)-3-hydroxypyr... 2 0
Arachidonate 5-lipoxygenase inhibitor methyl 5-[1-(2-butyl-1-b... 2 4
Metabotropic glutamate receptor 2 ligand (5R)-3-[[4-(4-ethoxyp... 3 9
Putative NP ZINC20611663 Family 4 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00378807 CHEMBL1916704 Bioactive 2-[3-[2-[[ethyl(methoxycarbonyl)amino]methyl]-4-(trifluoromethyl)phenyl]-4-methoxyphenyl]acetic acid
CFAMM00378813 CHEMBL1916708 Bioactive 2-[3-[2-[[(4-chlorophenyl)methoxycarbonyl-ethylamino]methyl]-4-(trifluoromethyl)phenyl]-4-methoxyphenyl]acetic acid
CFAMM00378812 CHEMBL1916702 Bioactive 2-[3-[2-[[cyclobutyl(phenylmethoxycarbonyl)amino]methyl]-4-(trifluoromethyl)phenyl]-4-methoxyphenyl]acetic acid
CFAMM00378818 CHEMBL1916699 Bioactive 2-[4-methoxy-3-[2-[[methyl(phenylmethoxycarbonyl)amino]methyl]-4-(trifluoromethyl)phenyl]phenyl]acetic acid
CFAMM00378811 CHEMBL1916701 Bioactive 2-[3-[2-[[cyclopropyl(phenylmethoxycarbonyl)amino]methyl]-4-(trifluoromethyl)phenyl]-4-methoxyphenyl]acetic acid
CFAMM00378817 CHEMBL1916697 Bioactive 2-[3-[2-[[benzyl(methoxycarbonyl)amino]methyl]-4-(trifluoromethyl)phenyl]-4-methoxyphenyl]acetic acid
CFAMM00378810 CHEMBL1916700 Bioactive 2-[3-[2-[[ethyl(phenylmethoxycarbonyl)amino]methyl]-4-(trifluoromethyl)phenyl]-4-methoxyphenyl]acetic acid
CFAMM00378816 CHEMBL1668891 Bioactive SureCN139356
CFAMM00378809 CHEMBL1916707 Bioactive 2-[3-[2-[[(3-chlorophenyl)methoxycarbonyl-ethylamino]methyl]-4-(trifluoromethyl)phenyl]-4-methoxyphenyl]acetic acid
CFAMM00378815 CHEMBL2181754 Bioactive 2-[3-[2-[[cyclopropanecarbonyl(ethyl)amino]methyl]-4-(trifluoromethyl)phenyl]-4-methoxyphenyl]acetic acid
CFAMM00378808 CHEMBL1916706 Bioactive 2-[3-[2-[[(2-chlorophenyl)methoxycarbonyl-ethylamino]methyl]-4-(trifluoromethyl)phenyl]-4-methoxyphenyl]acetic acid
CFAMM00378814 CHEMBL1916709 Bioactive 2-[3-[2-[[(3,5-dichlorophenyl)methoxycarbonyl-ethylamino]methyl]-4-(trifluoromethyl)phenyl]-4-methoxyphenyl]acetic acid

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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